Results 71 to 80 of about 5,012,000 (246)

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung   +15 more
wiley   +1 more source

Abstracts of papers presented during the 11th HUNGARIAN CONFERENCE ON RABBIT PRODUCTION: Kaposvár, Hungary. May 1999

open access: yes, 1999
World Rabbit Science (1999). Abstracts of papers presented during the 11th HUNGARIAN CONFERENCE ON RABBIT PRODUCTION: Kaposvár, Hungary. May 1999. World Rabbit Science. 07(4).
World Rabbit Science
core   +1 more source

Abstracts of the Genetics Section presented during the 8th World Rabbit Congress. Puebla, Mexico 7-10, 2004 [PDF]

open access: yes, 2005
World Rabbit Science (2005). Abstracts of the Genetics Section presented during the 8th World Rabbit Congress. Puebla, Mexico 7-10, 2004. World Rabbit Science. 13(1):49-64.
World Rabbit Science
core   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

open access: yesAdvanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li   +19 more
wiley   +1 more source

Recombinant Lactobacillus casei Expressing Capsid Protein VP60 can Serve as Vaccine Against Rabbit Hemorrhagic Disease Virus in Rabbits

open access: yesVaccines, 2019
Rabbit hemorrhagic disease virus (RHDV) is the causative agent of rabbit hemorrhagic disease (RHD). RHD, characterized by hemorrhaging, liver necrosis, and high morbidity and mortality in rabbits and hares, causes severe economic losses in the rabbit ...
Li Wang   +10 more
doaj   +1 more source

Pathomorphological characteristics of viral hemorrhagic disease of rabbits

open access: yesScientific Messenger of LNU of Veterinary Medicine and Biotechnologies, 2020
The dead animals have a pathomorphological picture with a brightly expressed hemorrhagic diathesis, in many organs there is venous stasis. Blood does not clot for several hours, and at autopsy of organs (heart, lungs, liver, kidneys) it is poured in significant amounts into the body cavity.
Z. V. Khomenko   +4 more
openaire   +3 more sources

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

open access: yesAdvanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang   +10 more
wiley   +1 more source

Diagnosis of viral infectious diseases in rabbits (myxomatosis, rabbit hemorrhagic disease)

open access: yesScientific Messenger of LNU of Veterinary Medicine and Biotechnologies
Myxomatosis and Rabbit Hemorrhagic Disease (RHD) are among the most widespread and dangerous viral infections of rabbits, leading to significant economic losses in livestock farms due to high mortality rates and reduced reproductive efficiency.
V. G. Skrypnyk, M. M. Verkholiuk
openaire   +1 more source

Abstracts of the Alternative and Sustainable production system section presented during the 8th World Rabbit Congress, Puebla, Mexico 7-10, 2004 [PDF]

open access: yes, 2005
World Rabbit Science (2005). Abstracts of the Alternative and Sustainable production system section presented during the 8th World Rabbit Congress, Puebla, Mexico 7-10, 2004. World Rabbit Science. 13(3).
World Rabbit Science
core   +1 more source

FAM134B Restricts African Swine Fever Virus Capsid Assembly via Reticulophagy and Its Antiviral Activity is Antagonized by the Viral Virulence‐Associated Factor pMGF300‐2R

open access: yesAdvanced Science, EarlyView.
ABSTRACT African swine fever (ASF), caused by African swine fever virus (ASFV), is a devastating viral disease in domestic pigs and wild boar. ASFV is a large DNA virus whose capsid assembly takes place within perinuclear viral factories (VFs). Accumulating evidence has demonstrated that reticulophagy confers antiviral activity against multiple RNA ...
Rui Luo   +9 more
wiley   +1 more source

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