Results 141 to 150 of about 83,967 (245)
Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9461-9472, October 2026.ABSTRACT Aim Although finerenone has shown efficacy in randomized trials, evidence from routine clinical practice remains limited. We aimed to assess the real‐world effectiveness and safety of finerenone in people with type 2 diabetes (PWT2D) and chronic kidney disease (CKD), with a particular focus on residual cardiorenal risk as reflected by changes ...
Oscar Moreno‐Pérez +13 more
wiley +1 more source
Chinese Journal of Contemporary Neurology and Neurosurgery, 2016 Objective To investigate whether Rac1 inhibitor has a synergistic effect on temozolomide (TMZ) in inhibiting the proliferation, migration and invasiveness of glioma cells. Methods Human glioma cell lines U87 and U251 were cultured by Rac1 inhibitor,
Xiao-yong HAN +5 more
doaj
Syntaxin‐3 Regulates Tight Junction Assembly in Human Retinal Pigment Epithelium
Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.ABSTRACT The retinal pigment epithelium (RPE) consists of polarized epithelial cells, serving as a support system for photoreceptor maintenance, where the polarity is contributed by the distribution of syntaxins (STX) within the cell. STX3, a known regulator of apical trafficking in epithelial cells, was previously understood to be absent in human RPE ...
Athira Ramesh +3 more
wiley +1 more source
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.The primary function of statins is to inhibit cholesterol synthesis, which contributes to their antidiabetic effects. However, the majority of the diabetic effects of statins are due to inhibition of isoprenoid synthesis. Atorvastatin, simvastatin and rosuvastatin possess the most pronounced diabetogenic properties. In contrast, lovastatin, fluvastatin,
Ali Nosrati Andevari, Mohsen Koolivand
wiley +1 more source
The Role of Hippocampal Interneuron Migration in Neurodevelopmental Disorders: A Systematic Review
Hippocampus, Volume 36, Issue 5, September 2026.ABSTRACT Hippocampal abnormalities are frequently associated with neurodevelopmental disorders as interneurons are crucial in establishing the network connectivity of neurons. This systematic review analyzed primary literature with a focus on aberrant hippocampal interneuron migration as an etiology for neurodevelopmental disorders, summarizing the ...
M. A. C. Till +3 more
wiley +1 more source
Hematological Oncology, Volume 44, Issue 5, September 2026.ABSTRACT BCL6 is a master transcriptional regulator of germinal center (GC) B cells. BCL6 is frequently translocated at the major translocation cluster (MTC) within intron 1 of the BCL6 locus, a hotspot commonly rearranged in diffuse large B cell lymphomas (DLBCLs).
Santosh Kumar Gothwal +4 more
wiley +1 more source
MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen +3 more
wiley +1 more source
Shelterin TPP1 Promotes Hair Regeneration Through Activating Bulge Hair Follicle Stem Cells
Aging Cell, Volume 25, Issue 9, September 2026.Elongation of telomeres by increasing TPP1, through genetic and pharmacological approaches, promotes hair follicle bulge stem cell mobilization and migration, leading to accelerated telogen‐to‐anagen transition and hair regeneration. This work identifies TPP1 as a master regulator and therapeutic target for alopecia. ABSTRACT Telomere shortening drives
Lihui Wang +17 more
wiley +1 more source