Results 11 to 20 of about 131,005 (322)
Rac1 S71 Mediates the Interaction between Rac1 and 14-3-3 Proteins [PDF]
Cells, 2019 Both 14-3-3 proteins (14-3-3s) and Rho proteins regulate cytoskeleton remodeling and cell migration, which suggests a possible interaction between the signaling pathways regulated by these two groups of proteins.
Abdalla Abdrabou +3 more
doaj +3 more sources
Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms [PDF]
Small GTPases, 2016 Abnormal Rac1 signaling is linked to a number of debilitating human diseases, including cancer, cardiovascular diseases and neurodegenerative disorders.
Hadir Marei, A. Malliri
semanticscholar +4 more sources
Melittin Prevents Metastasis of Epidermal Growth Factor-Induced MDA-MB-231 Cells through The Inhibition of The SDF-1α/CXCR4 Signaling Pathway [PDF]
Cell Journal, 2022 Objective: Melittin is one of the natural components of bee venom (Apis mellifera), and its anticancer and antimetastatic properties have been well established, but the underlying mechanism remains elusive.
Fatemeh Salimian +2 more
doaj +1 more source
Gut, 2022 Objective Increased apoptotic shedding has been linked to intestinal barrier dysfunction and development of inflammatory bowel diseases (IBD). In contrast, physiological cell shedding allows the renewal of the epithelial monolayer without compromising ...
L. Martínez-Sánchez +27 more
semanticscholar +1 more source
Rac1, A Potential Target for Tumor Therapy
Frontiers in Oncology, 2021 RAS-related C3 botulinum toxin substrate 1 (Rac.1) is one of the important members of Rho GTPases. It is well known that Rac1 is a cytoskeleton regulation protein that regulates cell adhesion, morphology, and movement.
Jiaxin Liang +14 more
semanticscholar +1 more source
The EMBO Journal, 2012 Since its description more than two decades ago as a substrate for botulinum C3 exoenzyme ([Didsbury et al , 1989][1]), Rac1 has been one of the most studied small GTPases of the Ras superfamily. Interest in Rac1 exploded in 1992 when Ridley and Hall published their seminal work showing that Rac1 regulates the actin cytoskeleton to promote lamellipodia
Frederick D, Tsai, Mark R, Philips
openaire +2 more sources
Short-hairpin RNA-mediated suppression of cortactin may inhibit the migration and invasion abilities of endometrial cancer cells by reducing lamellipodia [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): The prognosis of endometrial cancer (EC) is significantly affected by tumor infiltration and metastasis. Cortactin (CTTN) regulates infiltration and metastasis in other tumors. Studies on the role and mechanism of CTTN in EC are limited and
Huisi Lin +4 more
doaj +1 more source
PLoS ONE, 2021 Signaling by the Rho GTPase Rac1 is key to the regulation of cytoskeletal dynamics, cell spreading and adhesion. It is widely accepted that the inactive form of Rac1 is bound by Rho GDI, which prevents Rac1 activation and Rac1-effector interactions.
Jisca Majolée +3 more
doaj +1 more source
Compartmentalisation of RAC1 signalling [PDF]
Current Opinion in Cell Biology, 2018 RAC1 signalling has been implicated in a variety of dynamic cell biological processes that are orchestrated through regulated localisation and activation of RAC1. As a small GTPase, RAC1 switches between active and inactive states at various subcellular locations that include the plasma membrane, nucleus and mitochondria. Once activated, RAC1 interacts
Boben Payapilly, Aishwarya +1 more
openaire +4 more sources
Lysine Acetylation Reshapes the Downstream Signaling Landscape of Vav1 in Lymphocytes
Cells, 2020 Vav1 works both as a catalytic Rho GTPase activator and an adaptor molecule. These functions, which are critical for T cell development and antigenic responses, are tyrosine phosphorylation-dependent.
Sonia Rodríguez-Fdez +3 more
doaj +1 more source