Results 211 to 220 of about 83,967 (245)

Characterisation and outcome of RAC1 mutated melanoma

European Journal of Cancer, 2022
Activating hot spot R29S mutations in RAC1, a small GTPase influencing several cellular processes including cell proliferation and cytoskeleton rearrangement, have been reported in up to 9% of sun-exposed melanomas. Clinical characteristics and treatment implications of RAC1 mutations in melanoma remain unclear.We investigated the largest set (n = 64 ...
Georg C. Lodde, Philipp Jansen, Rudolf Herbst, Patrick Terheyden, Jochen Utikal, Claudia Pföhler, Jens Ulrich, Alexander Kreuter, Peter Mohr, Ralf Gutzmer, Friedegund Meier, Edgar Dippel, Michael Weichenthal, Antje Sucker, Jan-Malte Placke, Anne Zaremba, Lea Jessica Albrecht, Bernd Kowall, Wolfgang Galetzka, Jürgen C. Becker, Alpaslan Tasdogan, Lisa Zimmer, Elisabeth Livingstone, Eva Hadaschik, Dirk Schadendorf, Selma Ugurel, Klaus Griewank   +26 more
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Rac1 and Cholesterol Metabolism in Macrophage

Journal of Cardiovascular Pharmacology, 2013
In the early stages of atherosclerotic lesion development, cholesterol is mostly present as esterified cholesterol stored in macrophage cytoplasmic lipid droplets. However, when the lesion evolves, free cholesterol accumulates in other compartments, such as lysosomes and plasma membrane.
ADORNI, Maria Pia, RONDA, Nicoletta, BERNINI, Franco, FAVARI, Elda   +3 more
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Rac1 and Rac2 GTPases in haematopoiesis

BioEssays, 2004
AbstractThe highly homologous Rac1 and Rac2 GTPases are co‐expressed in cells of haematopoietic origin and are likely to show some functional redundancy. While disruption of the Rac2 gene in mice has provided insight into some of its functions, Rac1 null mice are embryonic lethal and only recently has conditional gene disruption been possible ...
Victoria J, Weston, Tatjana, Stankovic
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Regulation of anoikis by Cdc42 and Rac1

Experimental Cell Research, 2004
Ras family small GTPases play a critical role in malignant transformation, and Rho subfamily members contribute significantly to this process. Anchorage-independent growth and the ability to avoid detachment-induced apoptosis (anoikis) are hallmarks of transformed epithelial cells.
Tzu-Ling, Cheng, Marc, Symons, Tzuu-Shuh, Jou   +2 more
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RAC1 Takes the Lead in Solid Tumors [PDF]

Cells, 2019
Three GTPases, RAC, RHO, and Cdc42, play essential roles in coordinating many cellular functions during embryonic development, both in healthy cells and in disease conditions like cancers. We have presented patterns of distribution of the frequency of RAC1-alteration(s) in cancers as obtained from cBioPortal.
Jennifer Carlson Aske, Nandini Dey, Pradip De   +2 more
exaly   +4 more sources

Activation of Rac1 by human Tiam 1

2000
Publisher Summary This chapter describes the process of activation of Rac1 by human T-lymphoma invasion and metastasis 1 (Tiam1). The small GTPase Rac1 becomes activated via catalyzed displacement of bound GDP by a guanine nucleotide exchange factor (GEF). There are various Tiaml homologs with very similar domain organization.
G, Bollag, A M, Crompton, D, Peverly-Mitchell, G G, Habets, M, Symons   +4 more
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Rho A and Rac1: Antagonists moving forward

Tissue and Cell, 2020
Cells detect external stimuli through cell-surface receptors. In cases where the stimulus is a cytokine or a growth factor, the cell responds by inducing modifications in the actin cytoskeleton. These changes are mediated through the Rho family of GTPases. Among these GTPases, RhoA, Rac1 and Cdc42 have been extensively studied.
Salloum, Gilbert, Jaafar, Leila, El-Sibai, Mirvat   +2 more
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Phosphatidylserine Recruits Rac1

Science's STKE, 2006
Rac1 is a member of the Rho family of guanosine triphosphatases (GTPases) and is involved in stimulating membrane ruffling and cell migration. Finkielstein et al . show, using liposome-binding assays, nuclear magnetic resonance assays, and lipid overlay assays, that purified Rac1, either prenylated or nonprenylated,
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In silico screening of Rac1 ligand specificity

2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2008
Microtubule (MT) destabilization promotes the formation of actin stress fibers and enhances the contractility of cells. The actin cytoskeleton is bound to each junction and controls the integrity of each through actin remodeling and these junctions can be disassembled or assembled to either increase or decrease cellular permeability. Mediators, such as
P. Arrigo, MAGGI, NORBERT, RUGGIERO, CARMELINA   +2 more
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Actin' Up with Rac1

Science, 2000
The elegant architecture of photoreceptor cells in the retina is dependent on organization of the actin cytoskeleton during eye development. But what drives this organization? In an equally elegant Perspective, Colley explains new findings in fruit flies (Chang and Ready) that point to the photopigment rhodopsin and its signaling molecule the ...
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