Results 31 to 40 of about 45,252 (218)

Genetic alterations and markers of melanoma

Успехи молекулярной онкологии, 2015
Melanoma remains the most deadly form of malignant skin disease with high risk of metastases. Metastatic melanoma is prognostic highly unfavorable and resistant to traditional chemotherapy and biologic treatment.
N. N. Mazurenko
doaj   +1 more source

Characterization and functional analysis of the calmodulin-binding domain of Rac1 GTPase. [PDF]

PLoS ONE, 2012
Rac1, a member of the Rho family of small GTPases, has been shown to promote formation of lamellipodia at the leading edge of motile cells and affect cell migration.
Bing Xu, Prashen Chelikani, Rajinder P Bhullar   +2 more
doaj   +1 more source

Lack of RAC1 in macrophages protects against atherosclerosis.

PLoS ONE, 2020
The Rho GTPase RAC1 is an important regulator of cytoskeletal dynamics, but the role of macrophage-specific RAC1 has not been explored during atherogenesis. We analyzed RAC1 expression in human carotid atherosclerotic plaques using immunofluorescence and
Sashidar Bandaru, Chandu Ala, Matias Ekstrand, Murali K Akula, Matteo Pedrelli, Xi Liu, Göran Bergström, Liliana Håversen, Jan Borén, Martin O Bergo, Levent M Akyürek   +10 more
doaj   +2 more sources

Serine-71 phosphorylation of Rac1 modulates downstream signaling. [PDF]

PLoS ONE, 2012
The Rho GTPases Rac1 and Cdc42 regulate a variety of cellular functions by signaling to different signal pathways. It is believed that the presence of a specific effector at the location of GTPase activation determines the route of downstream signaling ...
Janett Schwarz, Julia Proff, Anika Hävemeier, Markus Ladwein, Klemens Rottner, Britta Barlag, Andreas Pich, Helma Tatge, Ingo Just, Ralf Gerhard   +9 more
doaj   +1 more source

Vascular endothelial growth factor‐C in activating vascular endothelial growth factor receptor‐3 and chemokine receptor‐4 in melanoma adhesion

Journal of Cellular and Molecular Medicine, Volume 26, Issue 23, Page 5743-5754, December 2022., 2022
Abstract Vascular endothelial growth factor‐C (VEGF‐C) binds to receptor vascular endothelial growth factor receptor‐3 (VEGFR‐3) expressed on lymphatic endothelial and melanoma cells. Binding of VEGF‐C to VEGFR‐3 enhances receptor phosphorylation that activates mitogen‐activated protein kinase (MAP‐K) and phosphatidylinositol‐3‐kinase (PI3K).
Yvette N. Hlophe, Anna M. Joubert
wiley   +1 more source

The PI3K inhibitor pictilisib and the multikinase inhibitors pazopanib and sorafenib have an impact on Rac1 level and migration of medulloblastoma in vitro

Journal of Cellular and Molecular Medicine, Volume 26, Issue 23, Page 5832-5845, December 2022., 2022
Abstract Metastatic disease is the leading cause of death in children suffering from medulloblastoma and a major treatment challenge. The evidence of leptomeningeal dissemination defines the most aggressive tumours and is associated with increased mortality; thus, inhibition of migration as a factor involved in the process of metastatic disease is ...
Leonie F. Schoen, Rogerio B. Craveiro, Torsten Pietsch, Thomas Moritz, Anja Troeger, Silvia Jordans, Dagmar Dilloo   +6 more
wiley   +1 more source

Cortactin: A universal host cytoskeletal target of Gram‐negative and Gram‐positive bacterial pathogens

Molecular Microbiology, Volume 118, Issue 6, Page 623-636, December 2022., 2022
In host‐pathogen interactions, actin‐cytoskeletal dynamics play a crucial role in successful adherence, invasion, and intracellular motility by many intruding microbes. To achieve this goal, bacterial pathogens target major host regulators, one of which is the key actin‐binding protein and class‐II actin nucleation‐promoting factor cortactin.
Irshad Sharafutdinov, Jakob Knorr, Klemens Rottner, Steffen Backert, Nicole Tegtmeyer   +4 more
wiley   +1 more source

Yersinia pseudotuberculosis Spatially Controls Activation and Misregulation of Host Cell Rac1. [PDF]

PLoS Pathogens, 2005
Yersinia pseudotuberculosis binds host cells and modulates the mammalian Rac1 guanosine triphosphatase (GTPase) at two levels. Activation of Rac1 results from integrin receptor engagement, while misregulation is promoted by translocation of YopE and YopT
Ka-Wing Wong, Ralph R Isberg
doaj   +2 more sources

Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population

FEBS Open Bio, EarlyView.
This study reports the upregulation of ELMO1 and GPR141 in human Fuchs' endothelial corneal dystrophy (FECD) corneal endothelium and ultraviolet A‐induced FECD mice model. A genetic association of an intergenic single nucleotide polymorphism rs918980 present between both genes is observed with FECD in the Indian population.
Susmita Sharma, Samar Kumar Basak, Sujata Das, Debasmita Pankaj Alone   +3 more
wiley   +1 more source

Inhibition of Rac1 in ventral hippocampal excitatory neurons improves social recognition memory and synaptic plasticity

Frontiers in Aging Neuroscience, 2022
Rac1 is critically involved in the regulation of the actin cytoskeleton, neuronal structure, synaptic plasticity, and memory. Rac1 overactivation is reported in human patients and animal models of Alzheimer’s disease (AD) and contributes to their spatial
Haiwang Zhang, Haiwang Zhang, Haiwang Zhang, Youssif Ben Zablah, Youssif Ben Zablah, Haorui Zhang, Haorui Zhang, An Liu, Radu Gugustea, Radu Gugustea, Dongju Lee, Dongju Lee, Xiao Luo, Xiao Luo, Yanghong Meng, Yanghong Meng, Song Li, Changxi Zhou, Tao Xin, Zhengping Jia, Zhengping Jia   +20 more
doaj   +1 more source