Results 51 to 60 of about 131,005 (322)
CYRI/ Fam49 Proteins Represent a New Class of Rac1 Interactors
Communicative & Integrative Biology, 2019 Fam49 proteins, now referred to as CYRI (CYFIP-related Rac Interactor), are evolutionarily conserved across many phyla. Their closest relative by amino acid sequence is CYFIP, as both proteins contain a domain of unknown function DUF1394.
Jamie A. Whitelaw +5 more
doaj +1 more source
Frontiers in Physiology, 2021 Ras-related C3 botulinum toxin substrate 1 (RAC1) activation plays a vital role in diabetic nephropathy (DN), but the exact mechanism remains unclear.
Changjiang Ying +7 more
doaj +1 more source
Myelination: all about Rac n roll. [PDF]
, 2007 During the development of the peripheral nervous system, Schwann cells select individual axons from a nerve bundle and establish a one-to-one relationship through a process termed radial sorting. Recent findings identify the Rho family GTPase Rac1 as the
Chan, Jonah
core +2 more sources
Molecular Cancer, 2019 Long noncoding RNAs (lncRNAs) are emerging as key players in the development and progression of cancer. However, the biological role and clinical significance of most lncRNAs in lung carcinogenesis remain unclear.
Juze Yang +13 more
semanticscholar +1 more source
Upon Wnt stimulation, Rac1 activation requires Rac1 and Vav2 binding to p120-catenin [PDF]
Journal of Cell Science, 2016 A role for Rac1 GTPase in canonical Wnt signaling has recently been demonstrated, showing that it is required for β-catenin translocation to the nucleus. In this study, we investigated the mechanism of Rac1 stimulation by Wnt. Upregulation of Rac1 activity by Wnt3a temporally correlated with enhanced p120-catenin binding to Rac1 and Vav2. Vav2 and Rac1
Valls, Gabriela +8 more
openaire +4 more sources
Regulation of cell protrusions by small GTPases during fusion of the neural folds
eLife, 2016 Epithelial fusion is a crucial process in embryonic development, and its failure underlies several clinically important birth defects. For example, failure of neural fold fusion during neurulation leads to open neural tube defects including spina bifida.
Ana Rolo +8 more
doaj +1 more source
Ninein is essential for apico-basal microtubule formation and CLIP-170 facilitates its redeployment to non-centrosomal microtubule organizing centres [PDF]
Open Biology, 2017 Differentiation of columnar epithelial cells involves a dramatic reorganization of the microtubules (MTs) and centrosomal components into an apico-basal array no longer anchored at the centrosome.
Deborah A. Goldspink +9 more
doaj +1 more source
Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines [PDF]
, 2017 Rac1 GTPase has long been recognized as a critical regulatory protein in different cellular and molecular processes involved in cancer progression, including acute myeloid leukemia.
Cabrera, Maia Diana Eliana +7 more
core +2 more sources
RAC1 Takes the Lead in Solid Tumors
Cells, 2019 Three GTPases, RAC, RHO, and Cdc42, play essential roles in coordinating many cellular functions during embryonic development, both in healthy cells and in disease conditions like cancers.
P. De, J. C. Aske, N. Dey
semanticscholar +1 more source
Genetic alterations and markers of melanoma
Успехи молекулярной онкологии, 2015 Melanoma remains the most deadly form of malignant skin disease with high risk of metastases. Metastatic melanoma is prognostic highly unfavorable and resistant to traditional chemotherapy and biologic treatment.
N. N. Mazurenko
doaj +1 more source