Results 61 to 70 of about 131,005 (322)

Ezrin-related phosphoinositide pathway modifies RhoA and Rac1 in human osteosarcoma cell lines [PDF]

, 2015
Selected Phosphoinositide-specific Phospholipase C (PI-PLC) enzymes occupy the convergence point of the broad range of pathways that promote Rho and Ras GTPase mediated signalling, which also regulate the activation of ezrin, a member of the ezrin ...
DELLA ROCCA, Carlo, Leopizzi, Martina, LO VASCO, VINCENZA RITA   +2 more
core   +1 more source

Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

Nature Communications, 2019
Rho family proteins are prenylated by geranylgeranyltransferase type I (GGTase-I), which normally target proteins to membranes for GTP-loading. However, conditional deletion of GGTase-I in mouse macrophages increases GTP-loading of Rho proteins, leading ...
Murali K. Akula, Mohamed X Ibrahim, Emil G. Ivarsson, Omar M. Khan, Israiel T. Kumar, M. Erlandsson, C. Karlsson, Xiufeng Xu, M. Brisslert, C. Brakebusch, Donghai Wang, M. Bokarewa, V. Sayin, M. Bergo   +13 more
semanticscholar   +1 more source

Reciprocal regulation of PKA and rac signaling [PDF]

, 2013
Activated G protein-coupled receptors (GPCRs) and receptor tyrosine kinases relay extracellular signals through spatial and temporal controlled kinase and GTPase entities.
A. Riml, Baillie, Bhola, Birukova, Cook, Cuevas, Daaka, Delcourt, Dewire, Dorsam, Dumaz, E. Stefan, Eblen, G. S. Baillie, Gerits, Gloerich, Hafner, Hoffmann, Howe, Jaffe, K. R. Liedl, Kinderman, King, Kraynov, Kumar, Ligr, Malbon, Manser, Molli, Nika, Pierce, R. G. Huber, Sahai, Sch  fer, Scott, Smith, Stefan, Stork, T. Valovka, Taylor, Thaker, V. A. Bachmann, Wang, Wennerberg, Wong, Zenke, Zhang, Zhao   +47 more
core   +1 more source

Rac1 Deletion Causes Thymic Atrophy

PLoS ONE, 2011
The thymic stroma supports T lymphocyte development and consists of an epithelium maintained by thymic epithelial progenitors. The molecular pathways that govern epithelial homeostasis are poorly understood. Here we demonstrate that deletion of Rac1 in Keratin 5/Keratin 14 expressing embryonic and adult thymic epithelial cells leads to loss of the ...
Hunziker, Lukas, Benitah, Salvador Aznar, Aznar Benitah, Salvador, Braun, Kristin M., Jensen, Kim, McNulty, Katrina, Butler, Colin, Potton, Elspeth, Nye, Emma, Boyd, Richard, Laurent, Geoff, Glogauer, Michael, Wright, Nick A., Watt, Fiona M., Janes, Sam M.   +14 more
openaire   +6 more sources

Cocaine activates Rac1 to control structural and behavioral plasticity in caudate putamen

Neurobiology of Disease, 2015
Repeated exposure to cocaine was previously found to cause sensitized behavioral responses and structural remodeling on medium spiny neurons of the nucleus accumbens (NAc) and caudate putamen (CPu).
Juan Li, Lei Zhang, Zhenzhong Chen, Minjuan Xie, Lu Huang, Jinhua Xue, Yutong Liu, Nuyun Liu, Fukun Guo, Yi Zheng, Jiming Kong, Lin Zhang, Lu Zhang   +12 more
doaj   +1 more source

Characterization and functional analysis of the calmodulin-binding domain of Rac1 GTPase. [PDF]

PLoS ONE, 2012
Rac1, a member of the Rho family of small GTPases, has been shown to promote formation of lamellipodia at the leading edge of motile cells and affect cell migration.
Bing Xu, Prashen Chelikani, Rajinder P Bhullar   +2 more
doaj   +1 more source

Voltage‐dependent activation of Rac1 by Nav1.5 channels promotes cell migration

bioRxiv, 2019
Changes in ion channel activity can regulate the plasma membrane potential (Vm) and alter cancer cell migration as a result of altered ion flux. However, the mechanism by which Vm regulates motility remains unclear.
Ming Yang, Andrew D. James, R. Suman, R. Kasprowicz, Michaela Nelson, P. O'Toole, W. Brackenbury   +6 more
semanticscholar   +1 more source

Lack of RAC1 in macrophages protects against atherosclerosis.

PLoS ONE, 2020
The Rho GTPase RAC1 is an important regulator of cytoskeletal dynamics, but the role of macrophage-specific RAC1 has not been explored during atherogenesis. We analyzed RAC1 expression in human carotid atherosclerotic plaques using immunofluorescence and
Sashidar Bandaru, Chandu Ala, Matias Ekstrand, Murali K Akula, Matteo Pedrelli, Xi Liu, Göran Bergström, Liliana Håversen, Jan Borén, Martin O Bergo, Levent M Akyürek   +10 more
doaj   +2 more sources

RAC1 inhibition reverses cisplatin resistance in esophageal squamous cell carcinoma and induces downregulation of glycolytic enzymes

Molecular Oncology, 2019
Development of chemoresistance remains a major challenge in treating esophageal squamous cell carcinoma (ESCC) patients despite treatment advances. However, the role of RAC1 in chemoresistance of ESCC and the underlying mechanisms remain largely unknown.
Ruijie Zeng, C. Zheng, Jing‐E Gu, Haixia Zhang, Lei Xie, Li-Yan Xu, E. Li   +6 more
semanticscholar   +1 more source

Serine-71 phosphorylation of Rac1 modulates downstream signaling. [PDF]

PLoS ONE, 2012
The Rho GTPases Rac1 and Cdc42 regulate a variety of cellular functions by signaling to different signal pathways. It is believed that the presence of a specific effector at the location of GTPase activation determines the route of downstream signaling ...
Janett Schwarz, Julia Proff, Anika Hävemeier, Markus Ladwein, Klemens Rottner, Britta Barlag, Andreas Pich, Helma Tatge, Ingo Just, Ralf Gerhard   +9 more
doaj   +1 more source