RAC1 P29S regulates PD-L1 expression in melanoma. [PDF]
, 2015 Whole exome sequencing of cutaneous melanoma has led to the detection of P29 mutations in RAC1 in 5-9% of samples, but the role of RAC1 P29 mutations in melanoma biology remains unclear.
Aplin, Andrew E. +4 more
core +2 more sources
Journal of Medicinal Plants, 2019 Background: Hypertension induced-left ventricular hypertrophy (LVH) is, at least initially, an adaptive response of the heart to pressure overload but it leads to heart failure if left untreated.
Fatemeh Mirabdollahi Shamsi +3 more
doaj
Rac1 S71 Mediates the Interaction between Rac1 and 14-3-3 Proteins
Cells, 2019 Both 14-3-3 proteins (14-3-3s) and Rho proteins regulate cytoskeleton remodeling and cell migration, which suggests a possible interaction between the signaling pathways regulated by these two groups of proteins.
Abdalla Abdrabou +3 more
doaj +1 more source
Rac1 plays a role in CXCL12 but not CCL3-induced chemotaxis and Rac1 GEF inhibitor NSC23766 has off target effects on CXCR4 [PDF]
, 2017 Cell migration towards a chemotactic stimulus relies on the re-arrangement of the cytoskeleton, which is triggered by activation of small G proteins RhoA, Rac1 and Cdc42, and leads to formation of lamellopodia and actin polymerisa ...
Beekman, Andrew +4 more
core +1 more source
Ezrin-related phosphoinositide pathway modifies RhoA and Rac1 in human osteosarcoma cell lines [PDF]
, 2015 Selected Phosphoinositide-specific Phospholipase C (PI-PLC) enzymes occupy the convergence point of the broad range of pathways that promote Rho and Ras GTPase mediated signalling, which also regulate the activation of ezrin, a member of the ezrin ...
DELLA ROCCA, Carlo +2 more
core +1 more source
Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery. [PDF]
, 2017 Neurite initiation is the first step in neuronal development and occurs spontaneously in soft tissue environments. Although the mechanisms regulating the morphology of migratory cells on rigid substrates in cell culture are widely known, how soft ...
Chang, Ting-Ya +9 more
core +2 more sources
Identification of Human Proteins vulnerable to multiple Organisms and their disease associations [PDF]
arXiv, 2016 While most studies emphasize on certain aspects of Pathogen-Host Interactions (PHI), such as the preferential attachment of bacteria or virus to its human receptor homolog, studies have attempted to methodically classify interactions among pathogenic proteins and their host proteins.
arxiv
ELMO1 has an essential role in the internalization of Salmonella Typhimurium into enteric macrophages that impacts disease outcome. [PDF]
, 2015 Backgrounds and aims4-6 million people die of enteric infections each year. After invading intestinal epithelial cells, enteric bacteria encounter phagocytes.
Casanova, James E +9 more
core
Coronin-1C Protein and Caveolin Protein Provide Constitutive and Inducible Mechanisms of Rac1 Protein Trafficking [PDF]
, 2015 Sustained directional fibroblast migration requires both polarized activation of the protrusive signal, Rac1, and redistribution of inactive Rac1 from the rear of the cell so that it can be redistributed or degraded.
Barrientos +42 more
core +1 more source
Characterization of Novel Molecular Mechanisms Favoring Rac1 Membrane Translocation. [PDF]
PLoS ONE, 2016 The Rac1 GTPase plays key roles in cytoskeletal organization, cell motility and a variety of physiological and disease-linked responses. Wild type Rac1 signaling entails dissociation of the GTPase from cytosolic Rac1-Rho GDP dissociation inhibitor (GDI ...
Antonio Castro-Castro +3 more
doaj +1 more source