Results 81 to 90 of about 83,967 (245)
Spatio-Temporal Regulation of Rac1 Mobility by Actin Islands. [PDF]
PLoS ONE, 2015 Rho GTPases play important roles in many aspects of cell migration, including polarity establishment and organizing actin cytoskeleton. In particular, the Rho GTPase Rac1 has been associated with the generation of protrusions at leading edge of migrating
Vinal V Lakhani +3 more
doaj +1 more source
Peripheral Blood DNA Methylation Changes Precede Lymphoma Diagnosis in Primary Sjögren's Disease
Arthritis &Rheumatology, EarlyView.Objective Primary Sjögren's disease (SjD) is a systemic autoimmune disease associated with an increased risk of lymphoma. The molecular mechanisms underlying lymphomagenesis remain poorly understood, and sensitive biomarkers for early identification of patients at high risk of developing lymphoma are lacking.
Hanna Lidberg +2 more
wiley +1 more source
Binding of pure CaM to Rac1(K153A), Rac1(R163A), and Rac1(K153A/R163A).
, 2012 Equal amount (20 µg) of wild type (WT) GST-Rac1 and different GST-Rac1 mutants were incubated with purified CaM (20 µg) in MOPS buffer and allowed to shake for 2 h at 4°C. GST beads were used as negative control.
Rajinder P. Bhullar (142507) +2 more
core +1 more source
Experimental study of Rac1 regulating osteoclast function in hypoxic environment
Kouqiang hemian waike zazhi[Objective:] To investigate the effect of hypoxia-inducible factor-1α (HIF-1α) on the changes of osteoclast bone resorption capacity by regulating Rac1 on cytoskeleton under hypoxic environment.
GU Jiahong, TIAN Yuanye, KANG Feiwu
doaj +1 more source
BMEMat, EarlyView.The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang +6 more
wiley +1 more source
Stretching Induces Overexpression of RhoA and Rac1 GTPases in Breast Cancer Cells
, 2019 Rho GTPases are well known for regulating cell morphology and intracellular interactions. They can either be oncogenic or tumor suppressors. However, these proteins are associated with the acquirement of malignant features by cancer cells.
Barton, Matthew +5 more
core +1 more source
BMEMat, EarlyView.This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu +9 more
wiley +1 more source
LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway [PDF]
, 2017 Leucine-rich repeat-containing G protein–coupled receptor 5 (LGR5) is a bona fide marker of adult stem cells in several epithelial tissues, most notably in the intestinal crypts, and is highly up-regulated in many colorectal, hepatocellular, and ovarian ...
Gong, Xing +9 more
core +1 more source
Agentic AI and Circular Procurement Performance: An Empirical Study
Business Strategy and the Environment, EarlyView.ABSTRACT Organizations that practice circular procurement in this rapidly changing world face many uncertainties. However, emerging digital technologies, such as agentic AI, can help manage resources and improve responsiveness to better serve both internal and external customers.
Surajit Bag +3 more
wiley +1 more source
, 2023 We provide evidence here from overexpression-based gain-of-function studies in human cells (1, 2) which demonstrate control of RAC1 by the NLR (nucleotide-binding oligomerization domain-like receptor) family protein NOD2. Cells expressing Crohn’s Disease NOD2 mutant L1007fsinsC are defective in transcriptional activation of RAC1.
openaire +1 more source