Results 101 to 110 of about 83,967 (245)

Role of the rat sarcoma virus gene-related C3 botulinum toxin substrate (RAC1) in neutrophil-mediated periodontitis: A narrative review

SRM Journal of Research in Dental Sciences
Introduction: Periodontitis is a chronic inflammatory disease initiated by microbial dysbiosis and perpetuated by an aberrant host immune response, resulting in the progressive destruction of the tooth-supporting tissues.
Vemuri Sai Mavya Naidu, V. Kalaivani, Gayathri Kumar, P. L. Ravishankar, K. Rajapandian   +4 more
doaj   +1 more source

Sex‐Specific Proteomic Profiling Identifies Pregnancy Zone Protein as a Complement‐Linked Marker of Adverse Prognosis in Esophageal Adenocarcinoma

International Journal of Cancer, EarlyView.
ABSTRACT Esophageal adenocarcinoma (EAC) exhibits marked male predominance with male‐to‐female ratios reaching 8.5:1, yet the molecular basis underlying this sex disparity remains poorly characterized. We analyzed 92 EAC specimens using mass spectrometry–based proteomics, comprising 47 female and 45 male tumors from treatment‐naïve patients ...
Alexander Quaas, Hanna Schiemann, Su Ir Lyu, Thomas Zander, Axel Hillmer, Hans Schlößer, Christiane J. Bruns, Reinhard Büttner, Bastian Grothey   +8 more
wiley   +1 more source

Vimentin is involved in regulation of mitochondrial motility and membrane potential by Rac1

Biology Open, 2015
In this study we show that binding of mitochondria to vimentin intermediate filaments (VIF) is regulated by GTPase Rac1. The activation of Rac1 leads to a redoubling of mitochondrial motility in murine fibroblasts.
Elena A. Matveeva, Larisa S. Venkova, Ivan S. Chernoivanenko, Alexander A. Minin   +3 more
doaj   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Redox regulation of Rac1 by thiol oxidation [PDF]

, 2015
The Rac1 GTPase is an essential and ubiquitous protein that signals through numerous pathways to control critical cellular processes, including cell growth, morphology, and motility.
Campbell, Sharon L., DeCristo, Molly J., Mitchell, Lauren E., Gunawardena, Harsha P., Arrington, Megan E., Loeser, Richard F., Hobbs, G. Aaron, Chen, Xian, Cox, Adrienne D.   +8 more
core   +1 more source

Smooth muscle Rac1 contributes to pulmonary hypertension

, 2022
International audienceBackground and purpose: Pulmonary hypertension (PH) is a multifactorial chronic disease characterized by an increase in pulmonary artery (PA) resistance leading to right ventricle (RV) failure. Endothelial dysfunction and alteration
Guignabert, Christophe, Angela Tesse, Rio, Marc, Gervaise Loirand, Lindsay Rose, Dilasser, Florian, Loirand, Gervaise, Rose, Lindsay, Florian Dilasser, Tesse, Angela, Vincent Sauzeau, Christophe Guignabert, Sauzeau, Vincent, Marc Rio   +13 more
core   +1 more source

The Small GTPase Rac1 Increases Cell Surface Stiffness and Enhances 3D Migration Into Extracellular Matrices

Scientific Reports, 2019
Membrane ruffling and lamellipodia formation promote the motility of adherent cells in two-dimensional motility assays by mechano-sensing of the microenvironment and initiation of focal adhesions towards their surroundings.
Tom Kunschmann, Stefanie Puder, Tony Fischer, Anika Steffen, Klemens Rottner, Claudia Tanja Mierke   +5 more
doaj   +1 more source

Myeloid Focal Adhesion Kinase Promotes Macrophage Accumulation but Does Not Alter Tumor Progression in Hepatocellular Carcinoma

Molecular Carcinogenesis, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) develops within an immunologically complex tumor microenvironment that is heavily shaped by infiltrating myeloid cells. Immune‐based treatment strategies such as atezolizumab plus bevacizumab have shown promising therapeutic benefits, but patients do not experience durable responses.
Eugene Ham, Kyle Boedeker, Claudia Rose Keating, Ruisong Ye, Frankie Montalbano, Sophia Mankaruse, Xianzhong Ding, Jonathan P. Rennhack, Wei Qiu   +8 more
wiley   +1 more source

Deciphering the Inflammatory Network in Pediatric Recurrent Tonsillitis: The Role of TRAF6, IRAK1, and miR‐146a‐5p

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To investigate the role of TNF receptor‐associated factor 6 (TRAF6), interleukin 1 receptor‐associated kinase 1 (IRAK1), and miR‐146a‐5p expression levels in the pathogenesis of recurrent tonsillitis. Study Design Case‐control study. Setting The study was conducted at the Department of Otorhinolaryngology, Muğla Training and Research
Ömer Faruk Güzel, Çilem Özdemir, Tuba Edgünlü, Ozan Gökdoğan   +3 more
wiley   +1 more source

GTPase Rac1 et ubiquitination

, 2007
Cette thèse a été consacrée à l étude de la régulation par ubiquitination d une protéine de signalisation cellulaire, la GTPase Rac1. J ai montré que l ubiquitination dégradative de Rac1 affecte peu son variant d épissage Rac1b, et qu elle requiert l ...
GACON, Gérard, VISVIKIS, Orane
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