Results 111 to 120 of about 83,967 (245)

Rac1 activation comes full circle [PDF]

The EMBO Journal, 2011
Precise spatiotemporal control of the Rac1 GTPase coordinates actin dynamics. A positive feedback loop involving the actin-binding protein coronin and the Rac regulators ArhGEF7, Pak1 and RhoGDI promotes Rac activity and actin polymerization at the cell cortex.
openaire   +2 more sources

Huntingtin as an Actin Organizer: Structural and Functional Insights

Cytoskeleton, EarlyView.
M. Capizzi, S. Humbert
wiley   +1 more source

Baicalein Sensitizes Radioresistant BT549 and MCF7‐R Breast Cancer Cells by Modulating Rac1 Signaling

Phytotherapy Research, EarlyView.
ABSTRACT Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistant BC models. Radioresistant BC cell models were established via fractionated irradiation and validated by
Zitong Zhao, Zhangyun Li, Quanzhou Peng, Shuqun Zhang   +3 more
wiley   +1 more source

BART Inhibits Pancreatic Cancer Cell Invasion by Rac1 Inactivation through Direct Binding to Active Rac1 [PDF]

, 2012
We report that Binder of Arl Two (BART) plays a role in inhibiting cell invasion by regulating the activity of the Rho small guanosine triphosphatase protein Rac1 in pancreatic cancer cells.
Taniuchi, Keisuke, Saibara, Toshiji, Yokotani, Kunihiko, Keisuke Taniuchi, Kunihiko Yokotani, Toshiji Saibara   +5 more
core   +1 more source

Engineering In Vitro Models of Skeletal Muscle With Neuromuscular Junctions Using Hierarchical Micro‐Nano Biomaterials: Cooperative Effect of Adhesion Ligand Nanoclustering and Surface Anisotropy

Small, EarlyView.
This study investigates the cooperative effects of adhesive ligand distribution, density, and biomaterial morphology for innervated skeletal muscle tissue engineering. Ligand nanoclusters were created in aligned micropatterns by electrospinning of a RAFT‐synthesized polymer with controlled ligand presentation.
Shirin Nour, Kristy Swiderski, Sahar Salehi, Gordon S. Lynch, Andrea J. O'Connor, Greg G. Qiao, Daniel E. Heath   +6 more
wiley   +1 more source

Fear Conditioning Downregulates Rac1 Activity in the Basolateral Amygdala Astrocytes to Facilitate the Formation of Fear Memory

Frontiers in Molecular Neuroscience, 2017
Astrocytes are well known to scale synaptic structural and functional plasticity, while the role in learning and memory, such as conditioned fear memory, is poorly elucidated.
Zhaohui Liao, Yezheng Tao, Xiaomu Guo, Deqin Cheng, Feifei Wang, Xing Liu, Lan Ma   +6 more
doaj   +1 more source

Three‐dimensional meso‐scale finite element modeling of recycled aggregate concrete using cohesive zone method

Structural Concrete, EarlyView.
Abstract The presence of adhered mortar (AM) in recycled aggregates (RAs) significantly affects the mechanical performance of recycled aggregate concrete (RAC). Meso‐scale modeling provides valuable insights into complex phase interactions, enabling a better understanding of RAC behavior.
Atabak Pourdadash Fardnam, Tuan Ngoc Nguyen, Vithushanthini Arulkumar   +2 more
wiley   +1 more source

Bond, tension‐stiffening, and cracking in multi‐generational recycled aggregate concrete subjected to shrinkage strains

Structural Concrete, EarlyView.
Abstract The concrete industry is responsible for a significant portion of global waste production and multi‐generation recycled aggregate concrete (MGRAC) is a means to allow the sector to transition to a circular economy framework. To predict the behavior of MGRAC at the member level there is a need to understand the underlying mechanics of bond ...
Lloyd Dadd, Phillip Visintin, Bree Bennett, Tianyu Xie   +3 more
wiley   +1 more source

Current Advances of Treatments, Therapeutic Targets, Biomarkers, Novel Drugs, and Machine Learning for Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive subtype of head and neck squamous cell carcinoma with insidious onset, early metastasis, and dismal prognosis. Conventional multimodal therapy achieves limited survival benefit, highlighting an urgent need for refined precision strategies.
Ce Li, Rui Guan, Rui‐Jie Jiao, Zhi‐Jie Bi, Yang Fu, Yin Wang, Chen‐Yang Xu, Ye Qian, Ran Wei, Sheng‐Da Cao, Wen‐Ming Li, Dong‐Min Wei, Da‐Peng Lei   +12 more
wiley   +1 more source

Rac1 in the driver’s seat for melanoma [PDF]

Pigment Cell & Melanoma Research, 2012
Laura M, Machesky, Owen J, Sansom
openaire   +2 more sources