Results 91 to 100 of about 83,967 (245)
Specific Inhibition of Rac1 Activation
, 2006 Rac1 is a member of a family of small GTPases that are primarily responsible for cellular motility and morphology. Activation of Rac1 by Rac-specific guanine nucleotide exchange factors (GEFs) is thought to be important for the metastasis of cancer cells.
Beaurivage, Scott
core +3 more sources
Labeling Strategies for Monitoring Cytoskeleton Dynamics in Cultured Epithelial Cells
Cytoskeleton, EarlyView.ABSTRACT Collective cell migration relies on coordinated cytoskeletal remodeling, yet the impact of live‐cell actin filament probes on these dynamics remains poorly characterized. Here, we systematically compared the performance and cellular effects of fluorogenic jasplakinolide‐based probes, SiR‐actin and SiR‐XActin, with the genetically encoded ...
Victoria Levario‐Diaz +6 more
wiley +1 more source
RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer
Colorectal cancer (CRC) remains a leading cause of cancer-related deaths, creating an urgent need for innovative diagnostic solutions. Mechanobiology, a cutting-edge field that investigates how physical forces influence cell behavior, is now revealing ...
Nguyen, Nam-Trung +5 more
core +1 more source
The role of Rho GTPases in facial morphogenesis
Developmental Dynamics, EarlyView.The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley +1 more source
Specific roles of Rac1 and Rac2 in motile functions of HT1080 fibrosarcoma cells
, 2009 Rho family proteins are constitutively activated in the highly invasive human fibrosarcoma HT1080 cells. We now investigated the specific roles of Rac1 and Rac2 in regulating morphology, F-actin organization, adhesion, migration, and chemotaxis of HT1080
Schlicht, Dominique +2 more
core +1 more source
The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle
ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley +1 more source
Vaginal host–microbe signatures linked to placental outcomes in mares
Equine Veterinary Journal, EarlyView.Abstract Background Ascending placentitis is a leading cause of late‐term pregnancy loss in mares. Although pathogens are presumed to ascend from the caudal reproductive tract, the association between the vaginal microbiome and placentitis has not been systematically examined.
Machteld van Heule +7 more
wiley +1 more source
, 2019 Entrevista en el programa Versió RAC1 que se puede recuperar siguiendo el enlaceEns han enganyat; no volen eliminar el dièsel perquè contamini.
Turiel, Antonio
core
Proposed model for Tie1-T794 phosphorylation by Rac1/PAK1 and modulation of Rac1 signaling.
, 2015 1) Angiogenic stimuli (e.g., extracellular matrix (ECM)-mediated integrin activation, VEGF stimulation, etc.) induce Rac1 activation (Rac1-GTP). 2) Rac1-GTP activates PAK1, resulting in PAK1 autophosphorylation. 3) PAK1 phosphorylates Tie1 on T794.
Jessica L. Reinardy (803462) +5 more
core +1 more source
Food Safety and Health, EarlyView.Dendrobium catenatum grown under simulated wild cultivation showed significantly higher flavonoids and stilbenes, leading to enhanced antioxidant activity in both leaves and stems compared to facility‐grown plants. Integrated metabolomics, antioxidant assays, and network pharmacology identified Denbinobin as a key multi‐target antioxidant compound ...
Chuyun Guan +7 more
wiley +1 more source