Results 71 to 80 of about 73,055 (186)

Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next

Photochemistry and Photobiology, EarlyView.
The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal, Durdana Muntaqua, Gagan Chhabra, Nihal Ahmad   +3 more
wiley   +1 more source

RNA-Binding Protein HuR Regulates Rac1 Nucleocytoplasmic Shuttling Through Nucleophosmin in the Intestinal EpitheliumSummary

Cellular and Molecular Gastroenterology and Hepatology, 2019
Background & Aims: The mammalian intestinal epithelium is a rapidly self-renewing tissue in the body, and its homeostasis is tightly regulated via well-controlled mechanisms.
Lan Liu, Lan Xiao, Hee K. Chung, Min S. Kwon, Xiao-Xue Li, Na Wu, Jaladanki N. Rao, Jian-Ying Wang   +7 more
doaj   +1 more source

Activation of Rac1 by a Crk SH3-binding protein, DOCK180 [PDF]

, 1998
Etsuko Kiyokawa, Yuko Hashimoto, Shin Kobayashi, Haruhiko Sugimura, Takeshi Kurata, Michiyuki Matsuda   +5 more
openalex   +1 more source

One minute of light‐intensity stair‐stepping decreases postprandial glycaemia in the evening in non‐diabetic adults: A randomized controlled trial

Experimental Physiology, EarlyView.
Abstract Prior studies have investigated the efficacy of a single 1 min bout of stair‐stepping on reducing postprandial blood glucose (BG) in the morning, but none have investigated this effect in the evening when glycaemic responses are larger due to circadian regulation and β‐cell responsiveness. This work investigated the efficacy of a 1 min bout of
Austin Morales, William Wong, Jeff Moore, Jochen Kressler   +3 more
wiley   +1 more source

Augmented Rac1 Expression and Activity are Associated with Oxidative Stress and Decline of β Cell Function in Obesity

Cellular Physiology and Biochemistry, 2015
Background: The aim of this study was to clarify the relationship among Rac1 expression and activation, oxidative stress and β cell dysfunction in obesity.
Shutong Zhou, Dongni Yu, Shangyong Ning, Heli Zhang, Lei Jiang, Lei He, Miao Li, Mingxiao Sun   +7 more
doaj   +1 more source

Cdc42 and Rac1 Regulate the Interaction of IQGAP1 with β-Catenin [PDF]

, 1999
Masaki Fukata, Shinya Kuroda, Masato Nakagawa, Aie Kawajiri, Naohiro Itoh, Ikuo Shoji, Yoshiharu Matsuura, Shin Yonehara, Hajime Fujisawa, Akira Kikuchi, Kozo Kaibuchi   +10 more
openalex   +1 more source

In vitro muscle contraction: A technical review on electrical pulse stimulation in C2C12 cells

Experimental Physiology, EarlyView.
Abstract Electrical pulse stimulation (EPS) of skeletal muscle cells is increasingly used to model exercise In vitro. The murine C2C12 myotube system has become a common platform for such studies, yet wide variability in EPS protocols hampers reproducibility and cross‐study comparisons.
Mark R. C. van de Meene, Anita M. van den Hoek, Roeland Hanemaaijer, Lars Verschuren, Jelle C. B. C. de Jong   +4 more
wiley   +1 more source

Quercetin suppresses ROS production and migration by specifically targeting Rac1 activation in gliomas

Frontiers in Pharmacology
P66Shc and Rac1 proteins are responsible for tumor-associated inflammation, particularly in brain tumors characterized by elevated oxidative stress and increased reactive oxygen species (ROS) production.
Rafia A. Baba, Rafia A. Baba, Hilal A. Mir, Hilal A. Mir, Taseem A. Mokhdomi, Hina F. Bhat, Ajaz Ahmad, Firdous A. Khanday   +7 more
doaj   +1 more source

The RhoA guanine exchange factor ABR: a glucose‐sensitive mediator of actin reorganization in feto‐placental arterial endothelial cells altered by gestational diabetes mellitus

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of proposed relationship between hyperglycaemia, gestational diabetes mellitus (GDM), active BCR‐related (ABR), RhoA and actin organization of feto‐placental arterial endothelial cells (fpEC). Hyperglycaemia upregulates ABR, which in turn increases RhoA activation.
Silvija Tokic, Boris Novakovic, Barbara Leopold‐Posch, Magdalena Mühlberger, Denise Hoch, Jelena Lögl, Eva M. Bernhart, Richard Saffery, Gernot Desoye, Ursula Hiden   +9 more
wiley   +1 more source

Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain [PDF]

, 1997
Veronica Colomer, Simone Engelender, Alan H. Sharp, Kui Duan, J.K. Cooper, A. Lanahan, G. L. Lyford, Paul F. Worley, Christopher A. Ross   +8 more
openalex   +1 more source