Results 71 to 80 of about 112,284 (228)
Cocaine activates Rac1 to control structural and behavioral plasticity in caudate putamen
Neurobiology of Disease, 2015 Repeated exposure to cocaine was previously found to cause sensitized behavioral responses and structural remodeling on medium spiny neurons of the nucleus accumbens (NAc) and caudate putamen (CPu).
Juan Li +12 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Patient‐derived cardiac organoids reveal key features of Duchenne muscular dystrophy cardiomyopathy, including apoptosis, oxidative stress, calcium handling defects, and mechanical remodeling. By integrating organoids into alginate–gelatin bioprinted constructs, disease phenotypes are organized into scalable 3D cardiac tissues displaying extracellular ...
Vittoria Marini +15 more
wiley +1 more source
A New Twist to Ibuprofen: Alternative Action in Alternative Splicing
European Medical Journal, 2019 Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) and is a widely used medication. One indication of NSAID use is long-term chemoprevention to decrease the risk of developing various types of cancer, in particular colorectal cancer.
Peter Jordan +2 more
doaj
RAC1 P29S regulates PD-L1 expression in melanoma. [PDF]
, 2015 Whole exome sequencing of cutaneous melanoma has led to the detection of P29 mutations in RAC1 in 5-9% of samples, but the role of RAC1 P29 mutations in melanoma biology remains unclear.
Aplin, Andrew E. +4 more
core +2 more sources
The Journal of Cell Biology, 2008 ![Graphic][1] Rac1 (white) is in the cytoplasm for G1 (left) but heads to the nucleus for G2 (right). Whether a cell is on the move or tangling with invading bacteria, the enzyme Rac1 is on the job.
openaire +1 more source
Advanced Healthcare Materials, EarlyView.A human microfluidic blood‐brain barrier (mBBB) model enables spatially resolved comparison of nanoparticle trafficking. Extracellular vesicles (EVs), liposomes, and nanoplastics exhibit distinct transport and disruption behaviors, revealing that membrane composition and uptake pathways govern BBB interaction.
Bryan B. Nguyen +9 more
wiley +1 more source
PLoS ONE, 2016 Macrophage-mediated inflammation has been implicated in various kidney diseases. We previously reported that Rac1, a Rho family small GTP-binding protein, was overactivated in several chronic kidney disease models, and that Rac1 inhibitors ameliorated ...
Miki Nagase +4 more
doaj +1 more source
Scientific Reports, 2023 RAC1 at 7p22.1 encodes a RAC family small GTPase that regulates actin cytoskeleton organization and intracellular signaling pathways. Pathogenic RAC1 variants result in developmental delay and multiple anomalies.
Rie Seyama +22 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2022 Rac1 is critically involved in the regulation of the actin cytoskeleton, neuronal structure, synaptic plasticity, and memory. Rac1 overactivation is reported in human patients and animal models of Alzheimer’s disease (AD) and contributes to their spatial
Haiwang Zhang +20 more
doaj +1 more source
ELMO1 has an essential role in the internalization of Salmonella Typhimurium into enteric macrophages that impacts disease outcome. [PDF]
, 2015 Backgrounds and aims4-6 million people die of enteric infections each year. After invading intestinal epithelial cells, enteric bacteria encounter phagocytes.
Casanova, James E +9 more
core