Results 71 to 80 of about 131,005 (322)
Rac1 activation comes full circle [PDF]
The EMBO Journal, 2011 Precise spatiotemporal control of the Rac1 GTPase coordinates actin dynamics. A positive feedback loop involving the actin-binding protein coronin and the Rac regulators ArhGEF7, Pak1 and RhoGDI promotes Rac activity and actin polymerization at the cell cortex.
openaire +2 more sources
Protein & Cell, 2019 Accelerated forgetting has been identified as a feature of Alzheimer’s disease (AD), but the therapeutic efficacy of the manipulation of biological mechanisms of forgetting has not been assessed in AD animal models.
Wenjuan Wu +11 more
semanticscholar +1 more source
Cancer Science, 2019 Rho GTPase Rac1 is a central regulator of F‐actin organization and signal transduction to control plasma membrane dynamics and cell proliferation. Dysregulated Rac1 activity is often observed in various cancers including breast cancer and is suggested to
Akari Murakami +9 more
semanticscholar +1 more source
Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects. [PDF]
, 2020 Genetic variants are the primary driver of congenital heart disease (CHD) pathogenesis. However, our ability to identify causative variants is limited.
Bernstein, Daniel +25 more
core
Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization,secondary mediators, and Rac [PDF]
, 2010 The C-type lectin-like receptor 2 (CLEC-2)activates platelets through Src and Syk tyrosine kinases via a single cytoplasmic YxxL motif known as a hem immunoreceptor tyrosine-based activation motif (hemITAM).Here, we demonstrate using sucrose gradient ...
Alice Y. Pollitt +44 more
core +1 more source
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
Nature Genetics, 2012 We characterized the mutational landscape of melanoma, the form of skin cancer with the highest mortality rate, by sequencing the exomes of 147 melanomas. Sun-exposed melanomas had markedly more ultraviolet (UV)-like C>T somatic mutations compared to sun-
M. Krauthammer +29 more
semanticscholar +1 more source
Rac1 GTPase in pancreatic cancer
Aging, 2015 Pancreatic cancer is the fourth leading cause of cancer death in the Western world. It is a disease of insidious progression and high lethality, with a 5 year survival rate of only 6%. In spite of significant advances in pancreatic cancer research, current therapies are ineffective and fail to significantly extend lifespan.
Ying, Yan, Michel M, Ouellette
openaire +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Yersinia pseudotuberculosis Spatially Controls Activation and Misregulation of Host Cell Rac1. [PDF]
PLoS Pathogens, 2005 Yersinia pseudotuberculosis binds host cells and modulates the mammalian Rac1 guanosine triphosphatase (GTPase) at two levels. Activation of Rac1 results from integrin receptor engagement, while misregulation is promoted by translocation of YopE and YopT
Ka-Wing Wong, Ralph R Isberg
doaj +2 more sources
Coronin-1C Protein and Caveolin Protein Provide Constitutive and Inducible Mechanisms of Rac1 Protein Trafficking [PDF]
, 2015 Sustained directional fibroblast migration requires both polarized activation of the protrusive signal, Rac1, and redistribution of inactive Rac1 from the rear of the cell so that it can be redistributed or degraded.
Barrientos +42 more
core +1 more source