Results 81 to 90 of about 85,005 (197)

Subcellular optogenetic activation of Cdc42 controls local and distal signaling to drive immune cell migration [PDF]

, 2016
Migratory immune cells use intracellular signaling networks to generate and orient spatially polarized responses to extracellular cues. The monomeric G protein Cdc42 is believed to play an important role in controlling the polarized responses, but it has
Gautam, N., Kalyanaraman, Vani, O\u27Neill, Patrick R   +2 more
core   +2 more sources

Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization,secondary mediators, and Rac [PDF]

, 2010
The C-type lectin-like receptor 2 (CLEC-2)activates platelets through Src and Syk tyrosine kinases via a single cytoplasmic YxxL motif known as a hem immunoreceptor tyrosine-based activation motif (hemITAM).Here, we demonstrate using sucrose gradient ...
Alice Y. Pollitt, Atkinson, Barrow, Beata Grygielska, Bertrand Leblond, Bodin, Bodin, Boggon, Christou, Colonna, Eble, Ezumi, Fuller, He, Hooley, Hughes, Huysamen, Johannes A. Eble, Kerrigan, Laurent Désiré, Lee, Locke, May, McCarty, Pestina, Piechulek, Pierce, Pleines, Quek, Sancho, Schacht, Shutes, Simons, Sobanov, Spalton, Steve P. Watson, Suzuki-Inoue, Suzuki-Inoue, Tolias, Walliser, Watson, Watson, Wonerow, Wonerow, Xu   +44 more
core   +1 more source

Augmented Rac1 Expression and Activity are Associated with Oxidative Stress and Decline of β Cell Function in Obesity

Cellular Physiology and Biochemistry, 2015
Background: The aim of this study was to clarify the relationship among Rac1 expression and activation, oxidative stress and β cell dysfunction in obesity.
Shutong Zhou, Dongni Yu, Shangyong Ning, Heli Zhang, Lei Jiang, Lei He, Miao Li, Mingxiao Sun   +7 more
doaj   +1 more source

Activation of Rac1 by a Crk SH3-binding protein, DOCK180 [PDF]

, 1998
Etsuko Kiyokawa, Yuko Hashimoto, Shin Kobayashi, Haruhiko Sugimura, Takeshi Kurata, Michiyuki Matsuda   +5 more
openalex   +1 more source

Cocaine activates Rac1 to control structural and behavioral plasticity in caudate putamen

Neurobiology of Disease, 2015
Repeated exposure to cocaine was previously found to cause sensitized behavioral responses and structural remodeling on medium spiny neurons of the nucleus accumbens (NAc) and caudate putamen (CPu).
Juan Li, Lei Zhang, Zhenzhong Chen, Minjuan Xie, Lu Huang, Jinhua Xue, Yutong Liu, Nuyun Liu, Fukun Guo, Yi Zheng, Jiming Kong, Lin Zhang, Lu Zhang   +12 more
doaj  

Vimentin is involved in regulation of mitochondrial motility and membrane potential by Rac1

Biology Open, 2015
In this study we show that binding of mitochondria to vimentin intermediate filaments (VIF) is regulated by GTPase Rac1. The activation of Rac1 leads to a redoubling of mitochondrial motility in murine fibroblasts.
Elena A. Matveeva, Larisa S. Venkova, Ivan S. Chernoivanenko, Alexander A. Minin   +3 more
doaj   +1 more source

A protective role for N-acylphosphatidylethanolamine phospholipase D in 6-OHDA-induced neurodegeneration. [PDF]

, 2019
N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) catalyzes the cleavage of membrane NAPEs into bioactive fatty-acid ethanolamides (FAEs). Along with this precursor role, NAPEs might also serve autonomous signaling functions. Here, we report that
Palese, Francesca, Piomelli, Daniele, Pontis, Silvia, Realini, Natalia   +3 more
core  

scGSDR: Harnessing Gene Semantics for Single-Cell Pharmacological Profiling [PDF]

arXiv
The rise of single-cell sequencing technologies has revolutionized the exploration of drug resistance, revealing the crucial role of cellular heterogeneity in advancing precision medicine. By building computational models from existing single-cell drug response data, we can rapidly annotate cellular responses to drugs in subsequent trials. To this end,
arxiv  

Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain [PDF]

, 1997
Veronica Colomer, Simone Engelender, Alan H. Sharp, Kui Duan, J.K. Cooper, A. Lanahan, G. L. Lyford, Paul F. Worley, Christopher A. Ross   +8 more
openalex   +1 more source

Circulating RAC1 contributed to steroid-sensitive nephrotic syndrome: Mendelian randomization, single-cell RNA-sequencing, proteomic, and experimental evidence

Renal Failure
Objectives The small GTPase Rac1 (RAC1) has been linked to podocyte disorders and steroid-sensitive nephrotic syndrome (SSNS). The aim of this study was to explore and validate the potential causal association between circulating RAC1 and SSNS.Methods ...
Yi Zhang, Tianwen Yao, Yanqiu Xu, Yi Wang, Shisheng Han   +4 more
doaj   +1 more source