Results 81 to 90 of about 73,055 (186)
The Journal of Physiology, EarlyView.Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani +5 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley +1 more source
The Influence of Schwann Cell Metabolism and Dysfunction on Axon Maintenance
Glia, Volume 73, Issue 12, Page 2338-2352, December 2025.Main Points Sensory neurons depend on Schwann cells for survival. Schwann cells provide energy for axons dunng rapid firing or after injury. Dysregulated metabolism in Schwann cells can lead to the production of neurotoxic and axon degeneration. ABSTRACT Schwann cells are the glial cells in the peripheral nervous system responsible for the production ...
Rose Follis +2 more
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Vav2 Activates Rac1, Cdc42, and RhoA Downstream from Growth Factor Receptors but Not β1 Integrins [PDF]
, 2000 Betty P. Liu, Keith Burridge
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JOR SPINE, Volume 8, Issue 4, December 2025.Intervertebral disc degeneration (IDD) is a multifactorial condition underpinned by complex molecular mechanisms. This review highlights advances in RNA sequencing and multi‐omics approaches that have elucidated gene regulatory networks, cellular heterogeneity, and progenitor cell dynamics in the nucleus pulposus.
Anja Stirnimann +3 more
wiley +1 more source
Hyaluronic Acid (Ha) Binding to Cd44 Activates Rac1 and Induces Lamellipodia Outgrowth [PDF]
, 2000 Snezhana Oliferenko +3 more
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Mechanisms That Prevent Vascular Leakage During Leukocyte Extravasation
Acta Physiologica, Volume 241, Issue 12, December 2025.ABSTRACT Background Inflammation is the response of the immune system against harmful stimuli in tissues. Leukocyte extravasation or TransEndothelial Migration (TEM) is a crucial step during inflammation, in which leukocytes migrate over the endothelial barrier toward the damaged tissue.
Siem J. de Haan, Jaap D. van Buul
wiley +1 more source
Scientific ReportsTongue squamous cell carcinoma (TSCC) remains an unsolved medical problem due to its poor local recurrence rate and prognosis. The purpose of this study was to investigate the expression characteristics of RAC-related C3 botulinum toxin substrate 1(RAC1)
Zongxuan He +5 more
doaj +1 more source
Rac1 Regulates Stress-induced, Redox-dependent Heat Shock Factor Activation [PDF]
, 2000 Michitaka Ozaki +4 more
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Advances in Magnesium Metal and Its Alloys for Promoting Angiogenesis
Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 113, Issue 11, November 2025.ABSTRACT Magnesium‐based materials show great promise for bone repair due to their biodegradability, bone‐like mechanical properties, and dual pro‐angiogenic/osteogenic activities. Pure magnesium implants enhance vascularization in bone defect models through Mg2+ release.
Junjie Huang +3 more
wiley +1 more source