Results 81 to 90 of about 112,284 (228)

Rac1 Protects Epithelial Cells against Anoikis [PDF]

Journal of Biological Chemistry, 2001
Rho family members play a critical role in malignant transformation. Anchorage-independent growth and the ability to avoid apoptosis caused by loss of anchorage (anoikis) are important features of transformed cells. Here we show that constitutive activation of Rac1 inhibits anoikis in Madin-Darby canine kidney (MDCK) epithelial cells.
S J, Coniglio, T S, Jou, M, Symons
openaire   +2 more sources

3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence

Advanced Healthcare Materials, EarlyView.
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes, Timo Rademakers, Ana Filipa Henriques Lourenço, Andrea Calore, Clarissa Tomasina, Denis van Beurden, Jinjie Venema, Bryan Chömpff, Hong Liu, Nicole Bouvy, Sandra Camarero‐Espinosa, Lorenzo Moroni   +11 more
wiley   +1 more source

Investigating the role of ras-related c3 botulinum toxin substrate 1(rac1) in modulating tumor necrosis factor alpha (tnf-α) mediated inflammation in a streptozotocin-induced mouse model of Alzheimer's disease

Zanco Journal of Medical Sciences
Background and objective: Alzheimer's disease (AD) is a slowly worsening brain disease linked to ongoing inflammation, with Tumor Necrosis Factor Alpha (TNF-α) playing a significant function in its progression.
Rundk Hwaiz
doaj   +1 more source

RAC1 nitration at Y32 IS involved in the endothelial barrier disruption associated with lipopolysaccharide-mediated acute lung injury

Redox Biology, 2021
Acute lung injury (ALI), a devastating illness induced by systemic inflammation e.g., sepsis or local lung inflammation e.g., COVID-19 mediated severe pneumonia, has an unacceptably high mortality and has no effective therapy.
Ting Wang, Manivannan Yegambaram, Christine Gross, Xutong Sun, Qing Lu, Hui Wang, Xiaomin Wu, Archana Kangath, Haiyang Tang, Saurabh Aggarwal, Stephen M. Black   +10 more
doaj   +1 more source

Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling [PDF]

, 2012
The functions of many organs depend on the generation of an epithelium. The transition from a set of loosely connected nonpolarized cells to organized sheets of closely associated polarized epithelial cells requires the assembly of specialized cell ...
Pieters, Tim, van Hengel, Jolanda, Van Roy, Frans   +2 more
core   +2 more sources

VE‐Cadherin–Actin Regulation Promotes Mechanotransduction and Monolayer Maturation Involving a Tension‐Sensitive Intermediate State

Advanced Science, EarlyView.
This study investigates how endothelial monolayers balance cohesion and plasticity during mechanical stimulation. In HUVECs, shear stress induces a tension‐sensitive intermediate state in which junctional VE‐cadherin and actomyosin relaxation levels coordinate actin/integrin remodeling. This rapid, reversible state strengthens cell junctions, preserves
Jonas Franz, Maria Odenthal‐Schnittler, Jan Philip Kipcke, Jochen Seebach, Zahra Labbaf, Franziska Merten, Vesna Bojovic, Muna Taha, Johannes A. Eble, Erez Raz, Milos Galic, Hans Schnittler   +11 more
wiley   +1 more source

Ameliorating of Transcription Level of gp91Phox and P22Phox Subunits of NADPH Oxdisae Complex in Hypertrophied Heart of Rats by Resveratrol

Journal of Medicinal Plants, 2019
Background: Hypertension induced-left ventricular hypertrophy (LVH) is, at least initially, an adaptive response of the heart to pressure overload but it leads to heart failure if left untreated.
Fatemeh Mirabdollahi Shamsi, Razieh Najjari, Ali Moradi, Fatemeh Safari   +3 more
doaj  

Spatio-Temporal Regulation of Rac1 Mobility by Actin Islands. [PDF]

PLoS ONE, 2015
Rho GTPases play important roles in many aspects of cell migration, including polarity establishment and organizing actin cytoskeleton. In particular, the Rho GTPase Rac1 has been associated with the generation of protrusions at leading edge of migrating
Vinal V Lakhani, Elizabeth Hinde, Enrico Gratton, Timothy C Elston   +3 more
doaj   +1 more source

Functions of p120ctn in development and disease [PDF]

, 2012
p120 catenin (p120ctn), a component of the cadherin-catenin complex, was the first member to be identified in a most interesting subfamily of the Armadillo family. Several p120ctn isoforms are generated by alternative splicing.
Pieters, Tim, van Hengel, Jolanda, Van Roy, Frans   +2 more
core   +1 more source

Who Pix up Rac1? [PDF]

The Journal of Cell Biology, 2006
Members of the large family of Rho GTPases are master regulators of the cytoskeletal changes necessary for cell adhesion, migration, and division. On page 759, ten Klooster et al. show how the activity of a Rho GTPase is spatially restricted by its COOH-terminal domain.
openaire   +1 more source