Results 61 to 70 of about 15,352 (140)

Suppl. Fig. S5 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42

, 2023
<p>Supplementary Figure S5 shows the effect of MBQ compounds on Rac activation in attached and detached cells.</p>
Suranganie Dharmawardhane, Cornelis P. Vlaar, Eliud Hernandez O'Farril, Marcelo G. Kazanietz, Mariana Cooke, Luis D. Borrero-Garcia, Tatiana Matos Gascot, Maria del Mar Maldonado, Ailed Cruz-Collazo, Julia I. Medina   +9 more
openaire   +1 more source

Suppl. Fig. S6 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42

, 2023
<p>Supplementary Figure S6 shows the inhibition of Rac1B, Rac1, and Rac1 P29S by MBQ-167</p>
Suranganie Dharmawardhane, Cornelis P. Vlaar, Eliud Hernandez O'Farril, Marcelo G. Kazanietz, Mariana Cooke, Luis D. Borrero-Garcia, Tatiana Matos Gascot, Maria del Mar Maldonado, Ailed Cruz-Collazo, Julia I. Medina   +9 more
openaire   +1 more source

Mechanism of ITGB2 in Osteoclast Differentiation in Osteoarthritis

Cell Proliferation, Volume 59, Issue 3, March 2026.
In osteoclast precursors, higher ITGB1 than ITGB2 expression increases ITGA2‐ITGB1 integrin. In OA, extracellular signals upregulate ITGB2 and downregulate ITGB1, enhancing ITGA2‐ITGB2 integrin. This activates Rac1 to Rac‐GTP, driving osteoclast differentiation. Hyperactive subchondral osteoclasts accelerate OA progression.
Yang Yang, Rui Sun, Zhibin Lan, Qi Ma, Gang Wu, Di Xue, Zhirong Chen, Yajing Su, Ye Ma, Xiaolei Chen, Jiangbo Yan, Long Ma, Xiaoxin He, Kuanmin Tian, Xiaoyi Ma, Xue Lin, Qunhua Jin   +16 more
wiley   +1 more source

Suppl. Fig. S2 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42

, 2023
<p>Supplemental Figure S2 shows the Effect of MBQ compounds on cell migration</p>
Suranganie Dharmawardhane, Cornelis P. Vlaar, Eliud Hernandez O'Farril, Marcelo G. Kazanietz, Mariana Cooke, Luis D. Borrero-Garcia, Tatiana Matos Gascot, Maria del Mar Maldonado, Ailed Cruz-Collazo, Julia I. Medina   +9 more
openaire   +1 more source

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge

Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.
In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle, Ella S Green, Jessie R Walker‐Rogers, Ha M Tran, David M Olson, Lachlan M Moldenhauer, Sarah A Robertson   +6 more
wiley   +1 more source

Supplementary Methods SM1 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42

, 2023
<p>Supplementary methods</p>
Suranganie Dharmawardhane, Cornelis P. Vlaar, Eliud Hernandez O'Farril, Marcelo G. Kazanietz, Mariana Cooke, Luis D. Borrero-Garcia, Tatiana Matos Gascot, Maria del Mar Maldonado, Ailed Cruz-Collazo, Julia I. Medina   +9 more
openaire   +1 more source

A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines

Advanced Science, Volume 13, Issue 8, 9 February 2026.
OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin, Chenchen Zhang, Jiahao Li, Kun Huang, Min Qiu   +4 more
wiley   +1 more source

Suppl. Fig. S3 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42

, 2023
<p>Suppl. Fig. S3 shows the effect of MBQ-167 and derivatives on lung cancer cells.</p>
Suranganie Dharmawardhane, Cornelis P. Vlaar, Eliud Hernandez O'Farril, Marcelo G. Kazanietz, Mariana Cooke, Luis D. Borrero-Garcia, Tatiana Matos Gascot, Maria del Mar Maldonado, Ailed Cruz-Collazo, Julia I. Medina   +9 more
openaire   +1 more source

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

Suppl. Fig. S4 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42

, 2023
<p>Supplementary Figure S4 shows the safety of MBQ compounds in mice.</p>
Suranganie Dharmawardhane, Cornelis P. Vlaar, Eliud Hernandez O'Farril, Marcelo G. Kazanietz, Mariana Cooke, Luis D. Borrero-Garcia, Tatiana Matos Gascot, Maria del Mar Maldonado, Ailed Cruz-Collazo, Julia I. Medina   +9 more
openaire   +1 more source