Results 71 to 80 of about 15,352 (140)

Phosphorylation induces altered protonation states and allosterically regulates Rac1–RhoGDI complex

Protein Science, Volume 35, Issue 1, January 2026.
Abstract Rho GTPases, critical for cellular functions like motility, are sequestered in an inactive GDP‐bound state by RhoGDI. While site‐specific RhoGDI phosphorylation is known to trigger selective GTPase release, the precise mechanisms remain elusive.
Krishnendu Sinha, Amit Kumawat, Hyunbum Jang, Ruth Nussinov, Suman Chakrabarty   +4 more
wiley   +1 more source

Suppl. Fig. S7 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42

, 2023
<p>Supplementary Figure S7 shows the effect of MBQ-167 on Rac1(G15A) association with Tiam-1 and p-REX-1.</p>
Suranganie Dharmawardhane, Cornelis P. Vlaar, Eliud Hernandez O'Farril, Marcelo G. Kazanietz, Mariana Cooke, Luis D. Borrero-Garcia, Tatiana Matos Gascot, Maria del Mar Maldonado, Ailed Cruz-Collazo, Julia I. Medina   +9 more
openaire   +1 more source

Cdc25‐Mediated Activation of the Small GTPase RasB Is Essential for Hyphal Fusion and Symbiotic Infection of Epichloë festucae

Molecular Plant Pathology, Volume 27, Issue 1, January 2026.
A conserved Cdc25–RasB signalling pathway, essential for hyphal fusion and host infection, is repurposed in Epichloë festucae to maintain a stable mutualistic symbiosis with grass hosts. ABSTRACT Epichloë festucae is a filamentous endophytic fungus that symbiotically colonises the intercellular spaces of aerial tissues in perennial ryegrass without ...
Mariko Inagaki, Shota Kamiya, Ayane Okamura, Atsushi Miura, Yuka Kayano, Aiko Tanaka, Daigo Takemoto   +6 more
wiley   +1 more source

Suppl. Fig. S8 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42

, 2023
<p>Supplementary Figure S8 shows nucleotide loading of GTP binding to Rho GTPases.</p>
Suranganie Dharmawardhane, Cornelis P. Vlaar, Eliud Hernandez O'Farril, Marcelo G. Kazanietz, Mariana Cooke, Luis D. Borrero-Garcia, Tatiana Matos Gascot, Maria del Mar Maldonado, Ailed Cruz-Collazo, Julia I. Medina   +9 more
openaire   +1 more source

Participation of the small molecular weight GTP-binding protein Rac1 in cell-free activation and assembly of the respiratory burst oxidase. Inhibition by a carboxyl-terminal Rac peptide.

Journal of Biological Chemistry, 1994
NADPH-dependent superoxide generation was activated by anionic amphiphiles plus GTP gamma S in a cell-free system consisting of plasma membranes plus recombinant p47-phox, p67-phox, and the small GTP-binding protein Rac1. Rac1 was expressed in Escherichia coli both as the native form and as a mutant form (Rac1(C189S)) lacking the prenylation site. When
M L, Kreck, D J, Uhlinger, S R, Tyagi, K L, Inge, J D, Lambeth   +4 more
openaire   +2 more sources

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Editorial on Dynamics of cAMP Signaling in Neurons: Sub-cellular Compartmentalization and Physiological Implications

Frontiers in Cellular Neuroscience, 2015
Pierre eVincent, Nicholas C Spitzer
doaj   +1 more source

The Histamine Four Receptor Regulates LFA-1 But Not Mac-1 -Dependent Neutrophil Adhesion and Inflammatory Functions. [PDF]

Inflammation
Dib K.
europepmc   +1 more source

Rho GTPases in cancer resistance: mechanisms, vulnerabilities, and therapeutic opportunities. [PDF]

Biochem Soc Trans
Beaudin A, Lefrançois P, Laurin M.
europepmc   +1 more source

Nucleotide-dependent switching and RIPb effector recognition of the barley susceptibility factor RACB. [PDF]

Commun Biol
Mohamadi M, Bradai M, Janowski R, Günsel U, Tran M, Kahl SM, McCollum C, Niessing D, Hückelhoven R, Hagn F.   +9 more
europepmc   +1 more source