Results 41 to 50 of about 993 (170)

Current and future treatments of pulmonary arterial hypertension

British Journal of Pharmacology, Volume 178, Issue 1, Page 6-30, January 2021., 2021
Therapeutic options for pulmonary arterial hypertension (PAH) have increased over the last decades. The advent of pharmacological therapies targeting the prostacyclin, endothelin, and NO pathways has significantly improved outcomes. However, for the vast majority of patients, PAH remains a life‐limiting illness with no prospect of cure.
Natascha Sommer, Hossein A. Ghofrani, Oleg Pak, Sebastien Bonnet, Steve Provencher, Olivier Sitbon, Stephan Rosenkranz, Marius M. Hoeper, David G. Kiely   +8 more
wiley   +1 more source

Prescribing pattern for acute diarrhea in children: A survey of pediatricians from Maharashtra, India

Muller Journal of Medical Sciences and Research, 2022
Context: Irrational use of medications for acute diarrhea in children is rampant. We conducted this survey to analyze prescription practices among pediatricians for acute diarrhea and their deviation from standard treatment guidelines.
Vikram S Patra, Jeetendra B Gavhane, Priyanka S Amonkar   +2 more
doaj   +1 more source

Impact of clinically tested NEP/ACE inhibitors on tumor uptake of [111In-DOTA]MG11 [PDF]

, 2016
Background: We have recently shown that treatment of mice with the neutral endopeptidase (NEP) inhibitor phosphoramidon (PA) improves the bioavailability and tumor uptake of biodegradable radiopeptides.
Jong, M. (Marion) de, Kaloudi, A. (Katerina), Krenning, E.P. (Eric), Lymperis, E. (Emmanouil), Maina, T. (Theodosia), Nock, B.A. (Berthold), Valkema, R. (Roelf)   +6 more
core   +5 more sources

Sacubitril and valsartan fixed combination to reduce heart failure events in post-acute myocardial infarction patients [PDF]

, 2017
Heart failure is a term used to define a constellation of symptoms and signs that are commonly attributed to the inability of the heart to produce a cardiac output that meets the demands of the body. It remains a deadly disease, affecting between 1-2% of
Lang, C. C., Zaid Iskandar, M.
core   +2 more sources

Effects of add-on ultramicronized n-palmitol ethanol amide in patients suffering of migraine with aura. a pilot study [PDF]

, 2018
Background: Palmitoyl ethanol amide (PEA) is an endogenously produced substance showing anti-nociceptive effect through both receptor and non-receptor mediated effects at the level of different cellular and tissue sites.
Caroleo, Mc, Chirchiglia, D, Cione, E, Di Mizio, G, Faedda, N, Gallelli, L, Giacolini, T, Guidetti, V, Siviglia, S, Wang, M   +9 more
core   +2 more sources

The effectiveness of racecadotril in the treatment of rotavirus infection in children

Aktualʹnaâ Infektologiâ, 2020
The article deals with the effectiveness of the use of racecadotril preparation as a pathogenetic agent in the treatment of rotavirus infection in children. There were 40 patients under the age of 5 years with rotavirus infection under observation.
I.I. Nezghoda, O.M. Naumenko, A.A. Asaulenko, O.S. Onofriichuk, L.M. Brovinska, A.M. Kolesnyk, O.V. Nikulchenko, N.I. Sinchuk   +7 more
doaj   +1 more source

Efficacy of a New Hypotonic Oral Rehydration Solution Containing Zinc and Prebiotics in the Treatment of Childhood Acute Diarrhea: A Randomized Controlled Trial [PDF]

, 2011
Objective: To evaluate the efficacy of a hypotonic oral rehydration solution (ORS) containing zinc and prebiotics for treatment of acute diarrhea in children.
BERNI CANANI, ROBERTO, Cecere G, COSENZA, LINDA, De Marco G, Marino A, NOCERINO, RITA, PASSARIELLO, ANNALISA, RUOTOLO, SERENA, TARDI, MARIA, TERRIN, GIANLUCA   +9 more
core   +1 more source

Determination of racecadotril by HPLC in capsules

Indian Journal of Pharmaceutical Sciences, 2007
A simple, precise and rapid RP-HPLC method was developed for the determination of racecadotril in a pharmaceutical formulation using gemfibrozil as internal standard. Ratio of the peak area of analyte to internal standard was used for quantification. The chromatographic separation was carried out by using a Reverse Phase C18 column (BDS-Hypersil).
Annie Shirwaikar, Alex Joseph, Tanuja Singh, Sl Prabu, C. Dinesh Kumar   +4 more
openaire   +2 more sources

Drugs in Focus

Journal of Pediatric Gastroenterology and Nutrition, 2020
ABSTRACTAcute diarrhoea is a leading cause of morbidity and mortality in the paediatric population. Racecadotril is an antisecretory drug recommended as an adjuvant antidiarrhoeal treatment.In the small bowel, the enzyme neutral endopeptidase (NEP) inhibits the action of enkephalins, which prevent water and electrolyte hypersecretion. By inhibiting NEP,
Christos Tzivinikos, Rok Orel, Rok Orel, Corina Pienar, Marc A. Benninga, Emmanuel Mas, Jernej Dolinsek, Ilse Broekaert, Mike Thomson, Erasmo Miele, Nikhil Thapar, Nikhil Thapar, Nikhil Thapar, Carmen Ribes-Koninckx, Rut Anne Thomassen   +14 more
openaire   +9 more sources

Randomised clinical trial: efficacy of a new synbiotic formulation containing Lactobacillus paracasei B21060 plus arabinogalactan and xilooligosaccharides in children with acute diarrhoea. [PDF]

, 2012
BACKGROUND: Acute diarrhoea is a frequent problem in children with heavy economic burden for families and society. AIM: To test the efficacy of a new synbiotic formulation containing Lactobacillus paracasei B21060, arabinogalactan and ...
BERNI CANANI, Roberto, Cecere, G., Cosenza, L., De Marco, G., Di Costanzo, M., Leone, L., Micillo, M., Nocerino, Rita, Passariello, A., Passariello, Annalisa, Terrin, G.   +10 more
core   +1 more source