Results 131 to 140 of about 23,430 (289)

Application of crystallization inhibitors to chiral separations. 1. Design of additives to discriminate between the racemic compound and the pure enantiomer of mandelic acid

, 2013
In the context of the potential use of crystallization for spontaneous separation of racemates, it is well-known that the frequent appearance of racemic solid forms (racemic compounds) is a serious obstacle.
R. J. Davey (1812265), R. K. Mughal (1904413), Nicholas Blagden (17154133)   +2 more
core   +1 more source

Sustained pharmacodynamic effects of S‐ketamine on cortical excitability and resting‐state brain activity: A randomized, placebo‐controlled trial

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to investigate a set of pharmacodynamic biomarkers reflecting acute, delayed and sustained central nervous system effects of S‐ketamine, used as a tool compound for rapid‐acting antidepressant activity, with the goal of informing biomarker strategies for delayed antidepressant effects.
Catherine M. K. E. de Cuba, Annika A. de Goede, Joost. C. van Mechelen, Laura G. J. M. Borghans, Liam van der Aa, Erik Olofsen, Maria J. Juachon, Robert J. Doll, Amy Gillespie, Catherine J. Harmer, Gabriël E. Jacobs, Jules A. A. C. Heuberger   +11 more
wiley   +1 more source

Racemic mimics. Part 1. Nickel coordination compounds

Acta Crystallographica Section C Structural Chemistry
To date there are very few examples of crystallographically well-documented racemic mimics. The original discovery of this class of crystals occurred at a time when crystallography was in its infancy, data collection and processing were tedious and limited by X-ray equipment, and computing power was indeed limited.
Bernal, Ivan, Lalancette, Roger A.
openaire   +2 more sources

Deracemization of a racemic compound via its conglomerate-forming salt using temperature cycling

, 2016
Salts of chiral molecules, which originally crystallize as racemic compounds, could form conglomerates. The utilization of such conglomerate salts, as intermediates for the deracemization of corresponding racemic compounds, expands the theoretical ...
Wei W. Li, Li, Wei W., De Reus, Saskia C A, Vlieg, Elias, Meekes, H.L.M., Laura Spix, Saskia C. A. de Reus, Kramer, H.J.M., Joop H. ter Horst, Reus, S.C.A. de, Meekes, Hugo, Hugo Meekes, Elias Vlieg, Vlieg, E., Herman J. M. Kramer, Kramer, Herman J M, Spix, L., Li, W.W., ter Horst, J.H., Spix, Laura, ter Horst, Joop H.   +20 more
core   +1 more source

The roles of side chains in Y6‐series non‐fullerene acceptors for high‐performance organic solar cells

Bulletin of the Korean Chemical Society, EarlyView.
The development of organic solar cells (OSCs) has been driven by structural modifications of Y6‐series non‐fullerene acceptors. In particular, side‐chain engineering regulates solubility, molecular packing, and energy levels, enabling efficiencies to increase from 15.7% to over 20%.
Peddaboodi Gopikrishna, Bomi Kim, Jongnam Park, BongSoo Kim   +3 more
wiley   +1 more source

Shedding Light on Synthetic Autocatalysis: From Conventional Closed‐Shell Chemistries to Overlooked Open‐Shell Occurrences

Chemistry – A European Journal, EarlyView.
Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley   +1 more source

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

Chemistry – A European Journal, EarlyView.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Virginia Cristofori, Anna Fantinati   +4 more
wiley   +1 more source

The importance of screening solid-state phases of a racemic modification of a chiral drug: thermodynamic and structural characterization of solid-state phases of etiracetam

, 2013
In this contribution different solid-state forms of the racemic compound (RS)-2-(2-oxo-pyrrolidin-1yl)-butyramide are studied from a structural and thermal point of view.
Vermylen, Valérie, Wouters, Johan, Norberg, Bernadette, Vermylen, V., Leyssens, Tom, Herman, C., Norberg, B., Wouters, J.; id_orcid, Herman, Christelle, Leyssens, T.   +9 more
core   +1 more source

Methyl on the Bridge: 2‐Methyl Propellane as Precursor for 1,3‐Substituted 2‐Methylated Bicyclo[1.1.1]Pentanes

Chemistry – A European Journal, EarlyView.
The synthesis of 2‐methyl propellane and its conversion to various 1,2‐ and 1,2,3‐di‐ and trisubstituted bicyclopentanes is reported. Abstract Bicyclo[1.1.1]pentanes (BCPs) have emerged as isosteric replacements for mono‐ and para‐substituted benzene rings in medicinal and materials applications, involving substitution at the BCP bridgehead (1,3 ...
Sean R. Verschaeve, Mariana Gomes Manso, Tibo Van Eeckhoorn, Mark E. Light, Bruno Linclau   +4 more
wiley   +1 more source

Crystallization Behavior and Relaxation Dynamics of Supercooled S‑Ketoprofen and the Racemic Mixture along an Isochrone

, 2015
In this paper, we study crystallization behavior and molecular dynamics in the supercooled liquid state of the pharmaceutically important compound ketoprofen at various thermodynamic conditions.
Niss, Kristine, Adrjanowicz, Karolina, Paluch, Marian, Kaminski, Kamil   +3 more
core   +1 more source