Results 131 to 140 of about 3,741,215 (311)
The importance of screening solid-state phases of a racemic modification of a chiral drug: thermodynamic and structural characterization of solid-state phases of etiracetam [PDF]
, 2013 In this contribution different solid-state forms of the racemic compound (RS)-2-(2-oxo-pyrrolidin-1yl)-butyramide are studied from a structural and thermal point of view.
Vermylen, Valérie +9 more
core +1 more source
(3,4-Dihydroxyoxolan-2-yl)methyl 4-methylbenzenesulfonate
Acta Crystallographica Section E, 2010 The racemic title compound, C12H16O6S, possesses a five-membered ring that adopts an envelope-shaped conformation; the two hydroxy groups occupy quasi-axial positions. Adjacent molecules are linked by O—H...O hydrogen bonds to generate a ribbon
Sergey Dibrov +2 more
doaj +1 more source
Crystallization Behavior and Relaxation Dynamics of Supercooled S‑Ketoprofen and the Racemic Mixture along an Isochrone [PDF]
, 2015 In this paper, we study crystallization behavior and molecular dynamics in the supercooled liquid state of the pharmaceutically important compound ketoprofen at various thermodynamic conditions.
Niss, Kristine +3 more
core +1 more source
Non-Classical Studies for Cyclic Preferential Crystallization of a Stable Racemic Compound [PDF]
, 2020 De nombreux principes actifs pharmaceutiques sont des composés chiraux. Les deux énantiomères des molécules correspondantes présentent des propriétés chimiques et physiques identiques mais l’activité biologique est souvent associée à un seul des deux ...
Harfouche, Lina
core
Coordination Compounds of Alkali Metal Halides and Racemic Diaryl Diamines [PDF]
, 1969 Solid alkali metal coordination compounds of water soluble alkali metal salts of monobasic acids and racemic diamines are made by contacting an aqueous solution of the alkali metal salts with a solution of a racemic diamine compound of the formula ...
Marullo, Nicasio P
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Unravel hidden symmetry breaking in racemic compounds
Racemic compounds, consisting of an equimolar mixture of enantiomers in crystalline form, are conventionally regarded as fully symmetric and are often dismissed as a trivial phenomenon due to their abundance—as they account for a substantial fraction (90–95%) of entries in structural databases.
Weihao Wang +4 more
openaire +1 more source
Angewandte Chemie International Edition, EarlyView.An anomeric amide‐enabled divergent aldehyde functionalization sequence provides one‐pot access to unsymmetrical ureas, carbamates, thiocarbamates, thioesters, and amides. Key to this transformation is the formation of N‐Boc‐hydroxamate intermediates, which serve as platforms for orthogonal activation via Lossen‐type rearrangements, single‐electron ...
Jasper L. Tyler +6 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims This study aimed to investigate a set of pharmacodynamic biomarkers reflecting acute, delayed and sustained central nervous system effects of S‐ketamine, used as a tool compound for rapid‐acting antidepressant activity, with the goal of informing biomarker strategies for delayed antidepressant effects.
Catherine M. K. E. de Cuba +11 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.A 9,10‐dihydro‐9,10‐disilaanthracene platform was efficiently synthesized and features intrinsically electrophilic Si sites. Upon stepwise reductive Si─H bond cleavage, these Si sites are converted into nucleophilic centers. This controlled polarity switching also enables ambiphilic reactivity within a homo‐heteroelement framework.
Moritz Schmidt +4 more
wiley +1 more source