Results 121 to 130 of about 23,430 (289)

Convenient preparations of racemic and enantiopure methyl 6-oxopipecolate

, 1996
Short, convenient syntheses of racemic and enantiopure methyl 6-oxopipecolate are described, starting from either pipecolic acid or (S)-lysine respectively. The sequence for the latter compound relies upon improved methodology for the oxidation of C-6 of
Hermitage, SA, Heightman, TD, Moloney, MG, Moloney, Mark, Davies, CE   +4 more
core   +1 more source

“Doubly enantiophobic” behavior during crystallization of racemic 1,5-dihydro-2H-pyrrol-2-one thioether

, 2018
One racemate forms two conglomerates and no racemic compound.
Aigul R. Zaripova, Almira R. Kurbangalieva, Irina I. Vandyukova, Olga A. Lodochnikova, Aida I. Samigullina, Robert R. Fayzullin, Lubov N. Potapova   +6 more
core   +1 more source

Anomeric Amide Enabled Divergent Synthesis of Unsymmetrical Ureas, Carbamates, Thioesters, and Amides From Aldehydes

Angewandte Chemie International Edition, EarlyView.
An anomeric amide‐enabled divergent aldehyde functionalization sequence provides one‐pot access to unsymmetrical ureas, carbamates, thiocarbamates, thioesters, and amides. Key to this transformation is the formation of N‐Boc‐hydroxamate intermediates, which serve as platforms for orthogonal activation via Lossen‐type rearrangements, single‐electron ...
Jasper L. Tyler, Meiyi Zeng, Julius Wiener, Marie‐Christin Leusmann, Colin Stein, Constantin G. Daniliuc, Frank Glorius   +6 more
wiley   +1 more source

Deracemizing Racemic Compounds

, 2015
112 p.
openaire   +1 more source

Enantiomeric Separation of Racemic Drugs Using Chiral Self-Assembled Monolayers

, 2010
Enantiomeric separation of racemic drugs is a never ending battle for pharmaceutical chemists. Conventional approaches to separating enantiomers (mirror-image stereoisomers) typically rely on chromatography utilizing chiral stationary phases or reactions
Blaisdell, Thomas Powers
core  

The Oxidation Mechanisms of Saturated Fatty Acids: Formation of Hydroperoxide Isomers and Production of 2‐Alkanones and Lactones

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Saturated fatty acids (SFAs) are generally regarded simply as being resistant to oxidation compared with unsaturated fatty acids. However, it has long been reported that SFAs can undergo oxidation when heated at high temperatures, leading to the formation of unique degradation products such as 2‐alkanones and lactones.
Kanji Aoyagi, Shunji Kato, Kiyotaka Nakagawa   +2 more
wiley   +1 more source

Unravel hidden symmetry breaking in racemic compounds

Racemic compounds, consisting of an equimolar mixture of enantiomers in crystalline form, are conventionally regarded as fully symmetric and are often dismissed as a trivial phenomenon due to their abundance—as they account for a substantial fraction (90–95%) of entries in structural databases.
Weihao Wang, Fangyi Chen, Shaodong Zhang, zhenghong Chen, Yutong Sun   +4 more
openaire   +1 more source

Phase Diagrams of Praziquantel and Vanillic Acid Cocrystals: Racemic Compound and Conglomerate System

Praziquantel (PZQ) is widely used to treat schistosomiasis. However, this chiral active pharmaceutical ingredient (API) is still produced as a racemic compound while only the (R)-enantiomer is active.
Clément Brandel (1525927), Hugo Cercel (18186887), Joop H. ter Horst (7308401), Charline J. J. Gerard (17592546), Valérie Dupray (2195914), Yohann Cartigny (1525936), Clément Pinetre (17697588), Maxime D. Charpentier (10832886), Nicolas Couvrat (1525933), Morgane Sanselme (1490923)   +9 more
core   +1 more source

Formation of a Salt Enables Complete Deracemization of a Racemic Compound through Viedma Ripening

, 2016
Chiral purification is a very important step in the production of many products such as active pharmaceutical ingredients (API). These procedures are typically limited to a maximum yield of 50%.
Hugo Meekes (1410751), Alinda Alfring (1826755), Laura Spix (1826758), Elias Vlieg (1575982), Willem J. P. van Enckevort (1575970)   +4 more
core   +1 more source

Quantum Phenomena in Molecular and Biological Systems: A Decoherence‐Based Decision Framework With Falsifiable Predictions and a Failure‐Mode Taxonomy

Advanced Physics Research, EarlyView.
A physics‐grounded framework based on decoherence timescales (τ_dec vs τ_func), Markovian validity, and falsifiability criteria is applied across molecular systems to distinguish where quantum effects are necessary, marginal, or irrelevant. The analysis integrates quantum chemistry, biological quantum mechanisms, and quantum computing under a unified ...
Sarfaraz K. Niazi
wiley   +1 more source