“Doubly enantiophobic” behavior during crystallization of racemic 1,5-dihydro-2H-pyrrol-2-one thioether [PDF]
, 2018 One racemate forms two conglomerates and no racemic compound.
Aigul R. Zaripova +6 more
core +1 more source
Angewandte Chemie, EarlyView.A stereoselective functionalization method of cyclic imines under mild organocatalytic conditions was developed. Bifunctional cinchona alkaloid catalysts combined with carefully optimized reaction conditions to suppress background reactivity enabled highly enantio‐ and diastereoselective addition reactions of malonates to cyclic imines.
Frederic Kölblin, Helma Wennemers
wiley +2 more sources
Separation and enrichment of enantiopure from racemic compounds using magnetic levitation [PDF]
, 2018 Crystallization of a solution with high enantiomeric excess can generate a mixture of crystals of the desired enantiomer and the racemic compound. Using a mixture of S-/RS-ibuprofen crystals as a model, we demonstrated that magnetic levitation (MagLev ...
Wong, Shin Yee +6 more
core +1 more source
Supramolecular Polymer‐Surfactant Co‐Assemblies for Multivalent HSV‐1 Inhibition
Angewandte Chemie, EarlyView.Non‐covalent co‐assembly of BTA with antiviral surfactants produces ratio‐dependent morphologies. Fibrous supramolecular polymers exhibit superior HSV‐1 inhibition, revealing multivalent fiber‐virus interactions and highlighting supramolecular co‐assemblies as a powerful strategy for functional biomedical nanomaterials with demonstrated tunable ...
Christian Zoister +12 more
wiley +2 more sources
Trihexyphenidyl hydrochloride: a powder diffraction study
Acta Crystallographica Section E, 2010 In the cation of the title compound [systematic name: 1-(3-cyclohexyl-3-hydroxy-3-phenylpropyl)piperidinium chloride], C20H32NO+·Cl−, the cyclohexyl and piperidine rings are in chair conformations. In the crystal structure, cations and
Norberto Masciocchi +2 more
doaj +1 more source
Enantiomeric Separation of Racemic Drugs Using Chiral Self-Assembled Monolayers [PDF]
, 2010 Enantiomeric separation of racemic drugs is a never ending battle for pharmaceutical chemists. Conventional approaches to separating enantiomers (mirror-image stereoisomers) typically rely on chromatography utilizing chiral stationary phases or reactions
Blaisdell, Thomas Powers
core
Determining the enantioselectivity of chiral catalysts - mass spectrometry as a mechanistic and screening tool [PDF]
, 2014 This thesis is focused on the application of ESI-MS as a screening method and mechanistic tool for organocatalyzed reactions. In previous studies cationic metal complexes or iminium ions were the key intermediates to be detected by ESI-MS analysis.
Bächle, Florian
core +1 more source
Force‐Induced Control of Circularly Polarized Luminescence With Rotaxane Architecture
Angewandte Chemie, EarlyView.Force‐induced reversible on/off switching of circularly polarized luminescence is achieved with a rotaxane‐based supramolecular mechanophore. The mechanophore, featuring a chiral helicene luminophore, is incorporated as a first network cross‐linker into a double‐network organogel.
Keigo Nonaka +10 more
wiley +2 more sources
Crystal structure of 2-chloro-1-(3-ethyl-2,6-diphenylpiperidin-1-yl)ethanone
Acta Crystallographica Section E: Crystallographic Communications, 2015 In the racemic title compound, C21H24ClNO, the dihedral angle between the planes of the benzene rings is 86.52 (14)° and those between the benzene rings and the piperidine ring are 61.66 (14) and 86.39 (14)°.
V. Shreevidhyaa Suressh +4 more
doaj +1 more source
Phase Diagrams of Praziquantel and Vanillic Acid Cocrystals: Racemic Compound and Conglomerate System [PDF]
Praziquantel (PZQ) is widely used to treat schistosomiasis. However, this chiral active pharmaceutical ingredient (API) is still produced as a racemic compound while only the (R)-enantiomer is active.
Clément Brandel (1525927) +9 more
core +1 more source