Results 191 to 200 of about 3,741,215 (311)

Antiseizure potency and neurotoxicity of the enantiomers of fenfluramine and norfenfluramine in rats and correlations with their concentrations in plasma and brain

Epilepsia, EarlyView.
Abstract Objective Based on the evidence that fenfluramine‐induced anorexia, weight loss, and cardiovascular toxicity are primarily mediated by the d‐enantiomers of fenfluramine and its metabolite norfenfluramine, we investigated pharmacokinetic/pharmacodynamic correlations for the active enantiomers of fenfluramine and norfenfluramine in the rat ...
Yara Sheeni, Dinorah Barasch, Tawfeeq Shekh‐Ahmad, Emilio Perucca, Meir Bialer   +4 more
wiley   +1 more source

Discovery of Small-Molecule Inhibitors of the KCNQ1/Kv7.1 Potassium Channel with Virtual Screening and Functional Validation in Electrophysiological Assays and KCNQ1-Knockout Neural Stem Cells. [PDF]

ACS Chem Neurosci
Alam KA, Martí-Solans J, Schall D, Kumar S, Iqbal SM, Teigen K, Berkel S, Mauceri D, Haug BE, Liin SI, Lynagh T, Martinez A, Haavik J.   +12 more
europepmc   +1 more source

Application, Challenges, and Prospects of Non‐Thermal Processing Technologies for Seaweed Protein Extraction—A Review

Food Chemistry International, EarlyView.
This review highlights non‐thermal extraction technologies for seaweed proteins, emphasizing their mechanisms, impacts on protein structure and functionality, and sustainability potential. Key limitations related to species dependence, extract complexity, and scale‐up are discussed to guide future industrial and biorefinery applications.
Rahat Mahmud, Md Fuad Al Hasan, Shuvojit Roy, Tanvir Ahmed   +3 more
wiley   +1 more source

Synthesis, Properties, and Enantioseparation of Four-Ring Racemic Smectics. [PDF]

Materials (Basel)
Wojda E, Zając M, Perkowski P, Urbańska M.   +3 more
europepmc   +1 more source

Chiral perovskites for next‐generation chiral optoelectronics and spintronics

FlexMat, EarlyView.
Benefiting from structural inversion symmetry breaking and strong spin‐orbit coupling, chiral perovskites possess intriguing chiral optical and spin properties. We overview their advances and core applications in perovskite solar cells, circularly polarized light detectors and spin circularly polarized‐light‐emitting diodes, offering great potential ...
Mengyao Zhang, Rui Xu, Xueyan Hou, Sihan Du, Mengting Xu, Jia Wu, Zhichao Lin, Pei Liu, Qiang Zhuang, Xiaoming Zhao, Yang Yang, Wenda Shi, Wanlin Guo, Jie Kong   +13 more
wiley   +1 more source

Protein binding regulates complex configuration: comparative analysis of three dynamically racemic europium(iii) complexes. [PDF]

RSC Adv
Li H, Black DJ, Pal R, Parker D.
europepmc   +1 more source

Molecular Palaeontology Prospects From Exceptionally Preserved Eocene Brackish‐Water Bivalve Batissa sitakaraensis (Venerida: Corbiculidae) From Hokkaido, Japan

Geological Journal, EarlyView.
This study reports the exceptional preservation of the Eocene freshwater bivalve Batissa sitakaraensis from Hokkaido, Japan. Multimodal analyses reveal that both the aragonitic shell mineralogy and the delicate organic periostracum retain their original structural and chemical characteristics after millions of years.
Taro Yoshimura, Kazuki Hirota, Hiroyuki Kagi, Takashi Matsubara, Takenori Sasaki   +4 more
wiley   +1 more source

Nickel-Catalyzed Enantioconvergent Arylation of Unactivated Cyclic Electrophiles: Asymmetric Synthesis of 3-Substituted Pyrrolidines. [PDF]

Angew Chem Int Ed Engl
Wong THM, Tong X, Fu GC.
europepmc   +1 more source

Ostracod faunal and geochemical evidence for the impact of Hoxnian (MIS 11c) sea levels in eastern England

Journal of Quaternary Science, EarlyView.
ABSTRACT Marine isotope substage 11c (~426–366 ka) is widely regarded as the most recent Pleistocene interglacial that is broadly analogous to the Holocene. The timing and magnitude of sea‐level changes during MIS 11 have been much debated, particularly concerning whether sea levels were significantly higher than during the Holocene. Empirical evidence
Tom S. White, Jonathan A. Holmes, David J. Horne, David R. Bridgland   +3 more
wiley   +1 more source

Optimized Biomimetic Syntheses of Discorhabdin B and Aleutianamine Drives a Deeper Exploration of Their Anticancer Potential. [PDF]

J Am Chem Soc
Magann NL, Barnes GL, Schioldager R, Hörmann FM, Muñoz R, Han H, Von Hoff D, Vanderwal CD.   +7 more
europepmc   +1 more source