Results 211 to 220 of about 23,430 (289)

Human IDO2 exhibits unique binding affinities distinct to those of human IDO1

The FEBS Journal, EarlyView.
Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi, Ayumu Takahashi, So Murakami, Nami Adachi, Tina Fujimoto, Yohta Fukuda, Taku Yamashita, Tsuyoshi Inoue, Hirofumi Tsujino   +8 more
wiley   +1 more source

A distinct gene expression mechanism for d‐amino acid utilization in hyperthermophilic archaeon Pyrococcus horikoshii

The FEBS Journal, EarlyView.
The genes PH0137, PH0138, and PH0140 form a cluster in the genome of Pyrococcus horikoshii. The PH0140 gene encodes a transcription factor identified as a d‐amino acid‐responsive regulatory protein (DARP). In feast mode, l‐Ile‐bound DARP binds to the promoter and represses transcription of PH0137 and PH0138. In famine mode, DARP binds to d‐allo‐Ile and
Ryushi Kawakami, Tomoki Kawase, Taira Uehara, Haruhiko Sakuraba, Tomohiko Matsuzawa, Junji Hayashi, Toshihisa Ohshima   +6 more
wiley   +1 more source

Enantioselective Intramolecular C-H Alkylation Catalyzed by a Nonsymmetric Chiral Cobalt Porphyrin. [PDF]

J Am Chem Soc
Buchelt C, Breitenlechner S, Zuber J, Huber SM, Bach T.   +4 more
europepmc   +1 more source

A Review of Nonsteroidal Anti‐Inflammatory Drugs for Food‐Producing Animals With a Focus on Potential Applications for Farmed Finfish

Journal of Fish Diseases, EarlyView.
ABSTRACT In finfish aquaculture, there are several inflammatory diseases impacting productivity and animal welfare, however there are limited options available to veterinarians to treat inflammation and pain in fish. Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used in terrestrial animals raised for human consumption to treat a range of ...
Chloe J. English, Christine Huynh, William Roy, James W. Wynne, Hamish Rodger   +4 more
wiley   +1 more source

Benzochromanone and Benzochromene Natural Products: Synthetic Strategies and Total Syntheses. [PDF]

Chem Rec
Kumamoto T.
europepmc   +1 more source

Refining generic limits in Hyacinthinae (Asparagaceae, Scilloideae): Conflict and concordance between morphology and phylogenomics

Journal of Systematics and Evolution, EarlyView.
Using Angiosperms353 and plastid genome skimming approaches, the generic limits of Hyacinthinae were explored using DNA sequences to better understand their evolution. Floral morphology, a traditional generic delimiter, conflicts with the molecular groupings in many cases, but bulb morphology and cytogenetics define similar groups to DNA.
Hannah Hall, John David, Kálmán Könyves, Alastair Culham   +3 more
wiley   +1 more source

Synthesis of a Cannabidiol Precursor: Experimental Challenges and DFT Insights into β‑Elimination Barriers. [PDF]

ACS Omega
Bergami M, Trapella C, Compagnin G, Felletti S, Catani M, Pezzola S, Sabuzi F, Galloni P, Marchetti P, Cristofori V, Fantinati A, Illuminati D.   +11 more
europepmc   +1 more source

Assessment of Pollen Production, Pollen Viability, Autofertility and Paternal Success in Faba Bean (Vicia faba L.) for Better Exploitation of Grain Yield Heterosis

Plant Breeding, EarlyView.
ABSTRACT In animal‐pollinated plants, pollen dispersal depends on several plant and animal characteristics that can influence the paternal success of a plant. Paternal success affects the genetic contribution of a genotype to the next generation, which is relevant to plant breeding.
Lisa Brünjes, Wolfgang Link
wiley   +1 more source

Cascade transformation of 2-(diazoacetyl)-2<i>H</i>-azirines to 2-aroyl-3-hydroxy-1<i>H</i>-pyrroles via condensation with aromatic aldehydes. [PDF]

Beilstein J Org Chem
Zanakhov TO, Galenko EE, Novikov MS, Khlebnikov AF.   +3 more
europepmc   +1 more source

A Gamma Ray–Induced Dwarf and Early Mutant of Brassica juncea With Favourable Traits for Developing High‐Yielding, Dwarf/Semi‐Dwarf Genotypes

Plant Breeding, EarlyView.
ABSTRACT Introduction of dwarfism to cereals has set a new paradigm in crop improvement programmes. To date, very little progress has been made in the development of high‐yielding dwarf/semi‐dwarf genotypes in oilseed Brassica. Previous attempts using induced mutagenesis employed in the induction of dwarfism in Brassica crops yielded limited success ...
Shankar K. Bhujbal, Archana N. Rai, Sanjay J. Jambhulkar, Archana Joshi‐Saha   +3 more
wiley   +1 more source