Results 231 to 240 of about 23,430 (289)

Recent Advances in Organocatalytic Kinetic Resolution for the Synthesis of Axially Chiral Compounds. [PDF]

Molecules
Cui L, Zheng Y.
europepmc   +1 more source

Bioresorbable Scaffolds for Coronary Arteries: Where Do We Stand Today?

VIEW Medicine, Volume 1, Issue 1, August 2026.
Bioresorbable coronary scaffolds are moving from thick strut pitfalls to thinner, stronger, healing‐oriented designs. Integrating advances in materials, guided implantation with preparation, size, and postdilation steps, and resorption aligned to healing, we synthesize clinical evidence and chart a roadmap toward intelligent, transient platforms ...
Junya Matsuda, Tatsuya Watanabe, Satoshi Yuhara, John M. Kelly, Hirotsugu Kurobe, Toshiharu Shinoka   +5 more
wiley   +1 more source

Catalytic Asymmetric Hydration of Alkenes. [PDF]

J Am Chem Soc
Hatano H, Fernandes VA, Mukherjee S, Zhu C, Takahira A, Jiang P, Jin M, Harabuchi Y, Staub R, Gao M, Varnek A, Maeda S, Tsuji N, List B.   +13 more
europepmc   +1 more source

Orthogonal One‐Pot Dual Catalysis Enabled by a Hybrid Chiral Diene/Phosphine Ligand

Advanced Synthesis &Catalysis, Volume 368, Issue 14, 17 July 2026.
A hybrid chiral diene–phosphine ligand enables orthogonal one‐pot Rh/Pd relay catalysis, delivering high yields and enantioselectivities while outperforming dual‐ligand systems. A hybrid chiral diene‐phosphine ligand (L1) enables orthogonal one‐pot relay catalysis by integrating distinct metal‐coordination sites within a single molecular framework. The
Steven Jiménez‐Guailla, Simón Hernández‐Ortega, Carmen Ortiz‐Cervantes   +2 more
wiley   +1 more source

Copper-Catalyzed Enantioconvergent Nucleophilic Fluorination of Alkyl Electrophiles to Generate α-Fluoroamides. [PDF]

J Am Chem Soc
Wang ZY, Fu GC.
europepmc   +1 more source

Sustainable Synthesis of Bio‐Based Furanic and Aromatic Amines Using an Optimized Whole‐Cell Transaminase–Decarboxylase Cascade in E. coli RARE

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
A whole‐cell biocatalytic cascade in engineered Escherichia coli RARE couples the ω‐transaminase from Pseudomonas psychrotolerans with pyruvate decarboxylase from Zymomonas mobilis to shift transamination toward amine formation via pyruvate removal. Integration of the cascade into a chemo‐enzymatic synthesis pathway enables the scalable production of 2,
Laura Edit Barabás, Róbert Tőtős, Tímea Éva Csete, Raluca Bianca Tomoiagă, Monica Ioana Toşa, Csaba Paizs   +5 more
wiley   +1 more source

Structure-Guided Discovery of Selective Polo-Like Kinase 3 Inhibitors. [PDF]

ACS Med Chem Lett
Yap JL, Lovett G, Mason JW, Tucker J, Boe D, Chen A, Coffman KJ, DaSilva J, Dickinson T, Frattini V, Guan Y, Guiraldelli MF, Hou XJ, Jasti J, Kenton NT, Machin-Rivera R, Marroquin L, McClendon CL, McLaughlin M, Pecora A, Robinson MC, Stock IA, Tria GS, Tuttle J, Young JA, Zhang L, Lee AA.   +26 more
europepmc   +1 more source

Fluorinated Aminopiperidones as Non‐Glutarimide Thalidomide Analogs: Stereodivergent Synthesis and Validation

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Fluorinated aminopiperidones, designed as non‐glutarimide thalidomide analogs, were synthesized with full regio‐ and stereocontrol. The C*–CF3 used as carbonyl surrogate improved solubility and membrane interactions while abolishing cereblon binding.
Boštjan Adamlje, Tihomir Tomašič, Christian Steinebach, Sebastian Ebeling, Alexander Herrmann, Marcus D. Hartmann, Jessica L. Horner, Kinjal Bhadresha, Cindy H. Chau, William D. Figg, Izidor Sosič, Andrej Emanuel Cotman   +11 more
wiley   +1 more source

Increase of the AMPA-evoked response of pyramidal neurons in the rat medial prefrontal cortex following acute administration of ketamine and S-ketamine, but not R-ketamine. [PDF]

Int J Neuropsychopharmacol
El Mansari M, Okamoto N, Blier P.
europepmc   +1 more source

An Ugi–Joullié Platform for Medicinally Relevant 1,4‐Dihydrobenzothiazines

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
A series of benzothiazine derivatives was efficiently synthesized via an UJ‐2CR of a preformed imine and diverse isocyanides. The method features mild, room‐temperature conditions, broad functional‐group tolerance, and scalability, enabling rapid access to a chemically diverse library of 19 adducts with potential for further medicinal chemistry ...
Xiaofang Lei, Christina Tomza, Maria‐Aikaterini Giannakaki, Maria Gkountouva, Ioannis Olbasalis, Rafaela Maria Giappa, Constantinos C. Stoumpos, Christos Kontogiorgis, Alexander Dömling, Constantinos G. Neochoritis   +9 more
wiley   +1 more source