Results 91 to 100 of about 49,012 (231)

Targeting PRMTs Creates Vulnerability of DNA Double‐Stand Break Repair Pathways, and Potentiates Chemotherapy Efficacy in TNBC

Cancer Science, EarlyView.
Our work makes the proof of concept that there is a clinical benefit to target both PRMT1 and PRMT5 to maximize the anti‐tumoral effect of chemotherapy in triple negative breast cancer. ABSTRACT Patients with triple‐negative breast cancer (ER−, PR−, and HER2−) are routinely treated with chemotherapies that induce DNA damage.
Charlène Thiebaut, Sébastien Martinez, Ludivine Pruvost, Louisane Eve, Rania El‐Botty, Laura Sourd, Elodie Montaudon, Ahmed Dahmani, Heloise Derrien, Stéphanie Sentis, Coralie Poulard, Elisabetta Marangoni, Olivier Trédan, Muriel Le Romancer   +13 more
wiley   +1 more source

Cell line-specific efficacy of thermoradiotherapy in human and canine cancer cells in vitro [PDF]

, 2019
Objective Aims were to investigate sensitivity of various human and canine cancer cell lines to hyperthermia and the influence of particular treatment conditions, and to analyze the DNA-damage response and mode of cell death in cell line radiosensitized
Nytko, Katarzina J., Rohrer Bley, Carla, Scheidegger, Stephan, Thumser-Henner, Pauline, Weyland, Mathias S.   +4 more
core   +2 more sources

Activities of human recombination protein Rad51 [PDF]

Proceedings of the National Academy of Sciences, 1997
Homologous pairing and strand exchange, which are catalyzed by Escherichia coli RecA protein, are central to homologous recombination. Homologs of this protein are found in eukaryotes; however, little has been reported on the recombinase activities of the mammalian homologs, including the human protein, denoted ...
R C, Gupta, L R, Bazemore, E I, Golub, C M, Radding   +3 more
openaire   +2 more sources

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

Cell Proliferation, EarlyView.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu, Wenfeng Zhang, Xiao Jiang, Jianping Chen, Lei Zhu, Zhonghao Zhang, Jing Gu, Lulu Guo, Lin Ao, Qing Chen, Lei Sun, Yuhan Hu, Xin Wang, Yaxin Liu, Jia Cao, Fei Han, Jinyi Liu   +16 more
wiley   +1 more source

A novel small molecule RAD51 inactivator overcomes imatinib‐resistance in chronic myeloid leukaemia

EMBO Molecular Medicine, 2013
RAD51 recombinase activity plays a critical role for cancer cell proliferation and survival, and often contributes to drug‐resistance. Abnormally elevated RAD51 function and hyperactive homologous recombination (HR) rates have been found in a panel of ...
Jiewen Zhu, Longen Zhou, Guikai Wu, Heiko Konig, Xiaoqin Lin, Guideng Li, Xiao‐Long Qiu, Chi‐Fen Chen, Chun‐Mei Hu, Erin Goldblatt, Ravi Bhatia, A. Richard Chamberlin, Phang‐Lang Chen, Wen‐Hwa Lee   +13 more
doaj   +1 more source

Chromosomal integrity after UV irradiation requires FANCD2-mediated repair of double strand breaks [PDF]

, 2016
Fanconi Anemia (FA) is a rare autosomal recessive disorder characterized by hypersensitivity to inter-strand crosslinks (ICLs). FANCD2, a central factor of the FA pathway, is essential for the repair of double strand breaks (DSBs) generated during fork ...
Bocco, Jose Luis, Di Giorgio, Marina, Federico, Maria Belén, Gottifredi, Vanesa, Paviolo, Natalia Soledad, Radl, Daniela Betiana, Soria, Gastón, Vallerga, María   +7 more
core   +3 more sources

Homologous recombination mutants cause differing lethality between h− and h+ Schizosaccharomyces pombe strains due to mat1 heterochromatin

The FEBS Journal, EarlyView.
Homologous recombination (HR) in Schizosaccharomyces pombe is essential when mating‐type switching–induced double‐strand breaks (DSBs) form at the mat1 locus. In h90 and h− strains, efficient mat1 DSB formation renders HR indispensable unless suppressors block these breaks.
Peter Kolesar, Siarhei Paliavoi, Barbora Stefanovie, Jan Josef Palecek   +3 more
wiley   +1 more source

EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks [PDF]

, 2019
The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism. Here we show that the exosome is necessary for the repair of DNA double-strand breaks (DSBs) in human cells and that RNA clearance is an essential step in homologous ...
Bonath, Franziska, Domingo Prim, Judit, Endara Coll, Martin, Friedländer, Marc R., Huertas Sánchez, Pablo, Jimeno González, Sonia, Prados Carvajal, Rosario, Visa, Neus   +7 more
core   +2 more sources

Coupling of both a transactivation module and a double‐stranded DNA‐binding domain boosts Cas12i3 variant‐based cytosine and adenine editing in plants

Journal of Integrative Plant Biology, EarlyView.
Fusions of a transactivation module and a double‐stranded DNA‐binding domain produced effective Cas12i3 variant‐based cytosine and adenine base editors, with improved C‐to‐T and A‐to‐G base editing efficiency and expanded editing window. Generated herbicide‐resistant rice germplasm by using these base editors demonstrates their potential for precise ...
Chen Zhang, Jingying Li, Yucai Li, Lei Yan, Christina Seok Yien Yong, Shaoya Li, Yubing He, Lanqin Xia   +7 more
wiley   +1 more source

A large C-terminal Rad52 segment acts as a chaperone to Form and Stabilize Rad51 Filaments

Nature Communications
Homologous recombination (HR) is essential for the repair of DNA double-strand breaks and the restart of stalled replication forks. A critical step in HR is the formation of Rad51 nucleofilaments, which perform homology search and strand invasion of a ...
Emilie Ma, Fadma Lakhal, Eleni Litsardaki, Myriam Ruault, Maxime Audin, Natacha Levrier, Emilie Navarro, Mickaël Garnier, Laurent Maloisel, Jordane Depagne, Clémentine Brocas, Aurelien Thureau, Didier Busso, Xavier Veaute, Raphaël Guerois, Angela Taddei, Françoise Ochsenbein, Eric Coïc   +17 more
doaj   +1 more source