Results 141 to 150 of about 49,012 (231)

Molecular mechanism and biological pathway of high-expressed RAD51 in regulating cell adhesion and potentially affecting oral squamous cell carcinoma

Discover Oncology
Background Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the oral cavity, with over 70% of cases detected in advanced stages and a 5-year survival rate of 50%.
Yu-Xing Tang, Yu-Yan Pang, Yan Cui, Guo-Jiao Wu, Lin-Qing Huang, Chang-Zhan Zhou, Bin Li, Qi Li, Bang-Teng Chi, Rong-Quan He, Di-Yuan Qin, Jian-Di Li, Gang Chen, Dong-Ming Li, Yi-Wu Dang   +14 more
doaj   +1 more source

A Critical Analysis of the Impact of Etoposide as a Topoisomerase II Inhibitor in Cervical Cancer Treatment: A Review

Cancer Medicine, Volume 15, Issue 3, March 2026.
Etoposide mediated topoisomerase II inhibition in Cervical Cancer. ABSTRACT Background Etoposide is a semisynthetic derivative of podophyllotoxin and an FDA‐approved topoisomerase II inhibitor that induces DNA strand breaks leading to cancer cell death.
Nikitha Kotian, Yashaswini Reddy, Padmini Pai, Babitha Kampa Sundara   +3 more
wiley   +1 more source

Isolation, characterisation and expression patterns of a RAD51 ortholog from Pleurotus ostreatus [PDF]

AB: Using degenerated primers for conserved regions of RecA homologs we have isolated a gene from Pleurotus ostreatus that shows characteristic features of RAD51 homologs. The encoded amino acid sequence of P.
Griensven, L.J.L.D., van, Mikosch, T.S.P., Sonnenberg, A.S.M.   +2 more
core   +2 more sources

Chemotherapy‐Induced Myelosuppression in Patients With gBRCA‐m Epithelial Ovarian Cancer: A Retrospective Study

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Existing evidence indicates that germline BRCA mutation (gBRCA‐m) may increase chemotherapy sensitivity and toxicity. However, its role in chemotherapy‐induced myelosuppression (CIM) remains unclear. We conducted this study to investigate the influence of gBRCA‐m on CIM incidence and severity in patients with epithelial ovarian ...
Hongtao Hu, Xianglin Nie, Yuxin Jiang, Chaoyi Shi, Xing Chen, Weiyue Zhang, Shan Wu, Yanmei Cheng, Lin Zhang, Yi Jiang, Shulin Zhou, Chengyan Luo, Lin Yuan, Wenjun Cheng   +13 more
wiley   +1 more source

Inhibition of RAD51 by siRNA and Resveratrol Sensitizes Cancer Stem Cells Derived from HeLa Cell Cultures to Apoptosis

Stem Cells International, 2018
Cervical cancer is the second most frequent tumor type in women worldwide with cases developing clinical recurrence, metastasis, and chemoresistance. The cancer stem cells (CSC) may be implicated in tumor resistance to therapy.
Graciela Ruíz, Heriberto A. Valencia-González, Ismael León-Galicia, Enrique García-Villa, Alejandro García-Carrancá, Patricio Gariglio   +5 more
doaj   +1 more source

Altered DNA Methyltransferase Expression in Pulmonary Large‐Cell Neuroendocrine Carcinoma: Pilot Experimental Data Targeted DNMT1, DNMT3A, and DNMT3B

Cancer Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Introduction Large cell neuroendocrine carcinoma (LCNEC) is a subtype of non‐small‐cell lung carcinoma with poorly understood methylation characteristics, including the activity of DNA methyltransferases. Despite the pivotal role of DNA methyltransferases in epigenetic regulation, their expression profile in LCNEC remains unexplored.
Adam Put, Katerina Smesny Trtkova, Marcel Mittak, Petra Herentinova, Jana Vaculova, Radoslava Cernekova, Jozef Skarda   +6 more
wiley   +1 more source

RAD51 modulates in nasopharyngeal carcinoma cells by regulating Caspase-8-mediated pyroptosis

Discover Oncology
Objective Radiotherapy is a first-line treatment for nasopharyngeal carcinoma (NPC), but resistance to radiation remains a major clinical challenge. This study aimed to investigate the role of RAD51, a key homologous recombination repair protein, in ...
Fuchuan Xie, Jian Song, Yunming Tian, Xinyu Zhang, Tanhuan Chen, Meng Xu   +5 more
doaj   +1 more source

Casein kinase 1δ/ε inhibition suppresses CLL proliferation through cell‐intrinsic and microenvironmental mechanisms

HemaSphere, Volume 10, Issue 3, March 2026.
Abstract Chronic lymphocytic leukemia (CLL) is a consequence of pathological B‐cell accumulation in blood and lymphoid organs. Due to high refractoriness, CLL is still incurable in many cases; therefore, there is an urgent need to develop novel therapeutic options.
Antonia Mikulova, Hana Plesingerova, Michaela Chorvatova, Pavlina Kebkova, Jana Bartosikova, Petra Prochazkova, Jan Verner, Dominik Mulidran, Stepan Cada, Olga Vondalova‐Blanarova, Nela Kolcakova, Tomas Loja, Terezia Kurucova, Eva Hoferkova, Boris Tichy, Jana Kotaskova, Marek Mraz, Lukas Kubala, Pavlina Janovska, Vitezslav Bryja   +19 more
wiley   +1 more source

Therapeutic Gene Editing: DNA Repair Pathways, Emerging Editors, and Clinical Progress

iNew Medicine, Volume 2, Issue 1, March 2026.
ABSTRACT The field of gene editing has evolved rapidly over the past decade, progressing from programmable zinc‐finger nucleases (ZFNs) and transcription activator‐like effector nucleases (TALENs) to the widespread adoption of CRISPR‐Cas systems. First‐generation editors catalyzed genome engineering by introducing targeted double‐strand breaks (DSBs ...
Li‐Kuang Tsai, Youcai Xiong, Dongqi Liu, Dongshan Yang, Jifeng Zhang, Jie Xu, Renzhi Han, Y. Eugene Chen   +7 more
wiley   +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, Volume 2, Issue 1, Page 106-129, March 2026.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source