Results 191 to 200 of about 15,150 (235)
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International Journal of Radiation Oncology*Biology*Physics, 1989
Radiosensitization of hypoxic V79 Chinese hamster cells by 0.5 mM misonidazole at approximately 0-4 degrees C is substantially enhanced by pretreating the cells overnight with 0.1 mM buthionine sulfoximine, which lowers the cellular glutathione content to 5% of control values (from 4 mM to approximately 0.2 mM).
C J, Koch, C C, Stobbe, P, Hettiaratchi
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Radiosensitization of hypoxic V79 Chinese hamster cells by 0.5 mM misonidazole at approximately 0-4 degrees C is substantially enhanced by pretreating the cells overnight with 0.1 mM buthionine sulfoximine, which lowers the cellular glutathione content to 5% of control values (from 4 mM to approximately 0.2 mM).
C J, Koch, C C, Stobbe, P, Hettiaratchi
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Radiation Research, 1968
Dose-survival curves of four strains of E. coli-B/r her- try-, Bs-1, B/r CSH, and 15T-were obtained in the presence and in the absence of non-toxic levels of several thiol-binding agents-N-ethylmaleimide (NEM), iodoacetamide (IA), and hydroxymercuribenzoate (HMB). The degree of radiosensitization by these agents was estimated from the increase in slope
H, Moroson, D N, Tenney
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Dose-survival curves of four strains of E. coli-B/r her- try-, Bs-1, B/r CSH, and 15T-were obtained in the presence and in the absence of non-toxic levels of several thiol-binding agents-N-ethylmaleimide (NEM), iodoacetamide (IA), and hydroxymercuribenzoate (HMB). The degree of radiosensitization by these agents was estimated from the increase in slope
H, Moroson, D N, Tenney
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Radiation sensitivity modification by chemotherapeutic agents.
Cancer clinical trials, 1981Three chemotherapeutic agents, chlorambucil, mustargen, and BCNU-409962, being investigated for their possible clinical use in conjunction with radiation therapy have been shown in vitro to dramatically affect the characteristics of standard radiation survival curves (in V79 cells and spheroids).
F W, Hetzel +3 more
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Radiation sensitizing agents in clinical radiation and chemotherapy.
Journal of medicine, 1980Patients with bronchogenic carcinoma or with advanced pediatric solid tumours were treated with various radiation therapy schedules alone or with a new alkylating carbamate: AB 132. Drug therapy appeared to potentiate radiation therapy results without significant toxicity except for certain neurologic symptoms (myasthenia, nightmares, disturbances of ...
J L, Ambrus +3 more
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International Journal of Radiation Oncology*Biology*Physics, 1986
Radiosensitization of V79 Chinese hamster fibroblasts by 0.5 mM misonidazole is a smooth function of endogenous glutathione (GSH) levels as modulated upwards by pre-incubation in medium containing cysteamine, or downwards by pre-incubation in medium containing buthionine sulfoximine.
C J, Koch, C C, Stobbe, K A, Baer
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Radiosensitization of V79 Chinese hamster fibroblasts by 0.5 mM misonidazole is a smooth function of endogenous glutathione (GSH) levels as modulated upwards by pre-incubation in medium containing cysteamine, or downwards by pre-incubation in medium containing buthionine sulfoximine.
C J, Koch, C C, Stobbe, K A, Baer
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Journal of Medicinal Chemistry, 1991
In view of the in vivo demonstrated radiation-potentiating activities of several previously studied 2,2-dimethylphosphoraziridines, six new compounds incorporating the bis(2,2-dimethyl-1-aziridinyl)phosphinyl moiety, together with an electron-affinic group such as 2-nitroimidazole or nitrobenzyl, have been synthesized and tested (1) in vitro for ...
M E, Perlman +7 more
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In view of the in vivo demonstrated radiation-potentiating activities of several previously studied 2,2-dimethylphosphoraziridines, six new compounds incorporating the bis(2,2-dimethyl-1-aziridinyl)phosphinyl moiety, together with an electron-affinic group such as 2-nitroimidazole or nitrobenzyl, have been synthesized and tested (1) in vitro for ...
M E, Perlman +7 more
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Modulation of Alkylating Agents by Radiation Sensitizers— Clinical Aspects
1986Alkylating agents are among the most commonly used anticancer agents. They have the widest spectrum of antitumor activity of any class of agents. Individual alkylating agents usually are not cross resistant, since the mechanisms and sites of alkylation of each agent may differ considerably.
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International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1973
SummaryMeasurements were made of the synthesis of DNA by membrane-DNA complexes extracted from Escherichia coli B/r that had been sensitized to or protected against the lethal effects of ionizing radiation by irradiating the bacteria in the presence of indane trione, acriflavine, thiourea, or β-mercaptoethanol. Pre-irradiation treatment of the bacteria
W A, Cramp, H N, Fraval, J, Collins
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SummaryMeasurements were made of the synthesis of DNA by membrane-DNA complexes extracted from Escherichia coli B/r that had been sensitized to or protected against the lethal effects of ionizing radiation by irradiating the bacteria in the presence of indane trione, acriflavine, thiourea, or β-mercaptoethanol. Pre-irradiation treatment of the bacteria
W A, Cramp, H N, Fraval, J, Collins
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Radiation sensitizing and radiation protective agents in experimental radiation therapy.
Journal of medicine, 1989It appears that AB-132 potentiates radiation effects, and the local application of AET (MEG) protects the intestinal tract, the bladder and the skin against radiation toxicity. Combined use of selective radiation sensitizing and protecting agents may be considered for clinical studies.
J L, Ambrus +4 more
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Biophysik, 1973
The inactivation of three radiation-sensitive haploidSaccharomyces mutants, as well as that of corresponding homozygous diploid mutants, following treatment with the bifunctional alkylating agent diepoxybutane (DEB) or the monofunctional alkylating agents methylmethane-sulfonate (MMS) or methylnitrosoguanidine (MNG) was investigated.
W, Laskawski, E, Lehmann-Brauns
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The inactivation of three radiation-sensitive haploidSaccharomyces mutants, as well as that of corresponding homozygous diploid mutants, following treatment with the bifunctional alkylating agent diepoxybutane (DEB) or the monofunctional alkylating agents methylmethane-sulfonate (MMS) or methylnitrosoguanidine (MNG) was investigated.
W, Laskawski, E, Lehmann-Brauns
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