Results 11 to 20 of about 886,683 (209)
Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection
Cell Reports, 2020 Summary: Cells deficient in ataxia telangiectasia mutated (ATM) are hypersensitive to ionizing radiation and other anti-cancer agents that induce double-strand DNA breaks. ATM inhibitors may therefore sensitize cancer cells to these agents.
Mu-Yan Cai +9 more
doaj +1 more source
Circ-CPSF1 Worsens Radiation-Induced Oxidative Stress Injury in Caenorhabditis elegans
Biomolecules, 2023 Radioactive substances have been used in various aspects in daily life. However, high-energy radiation could cause environmental problems, which would damage the human body.
Jing Yuan +8 more
doaj +1 more source
Proton-induced DNA damage promotes integration of foreign plasmid DNA into human genome
Frontiers in Oncology, 2022 High-risk human papillomaviruses (HPVs) cause virtually all cervical cancer cases and are also associated with other types of anogenital and oropharyngeal cancers. Normally, HPV exists as a circular episomal DNA in the infected cell.
Meghri Katerji +7 more
doaj +1 more source
Exposure to Low-Dose Radiation Enhanced the Antitumor Effect of a Dendritic Cell Vaccine
Dose-Response, 2019 The unsatisfactory clinical efficacy of dendritic cell (DC)-based cancer vaccines prepared by conventional methods is partly due to their insufficient capacity for migration.
Sinian Wang +8 more
doaj +1 more source
Modulation of gene expression in endothelial cells in response to high LET nickel ion irradiation [PDF]
, 2014 Ionizing radiation can elicit harmful effects on the cardiovascular system at high doses. Endothelial cells are critical targets in radiation-induced cardiovascular damage.
Aerts, An +15 more
core +1 more source
FANCD2 Binds CtIP and Regulates DNA-End Resection during DNA Interstrand Crosslink Repair
Cell Reports, 2014 The Fanconi anemia (FA) pathway is critically involved in the maintenance of hematopoietic stem cells and the suppression of carcinogenesis. A key FA protein, FANCD2, is monoubiquitinated and accumulates in chromatin in response to DNA interstrand ...
Junya Unno +11 more
doaj +1 more source
Stem Cell Reports, 2014 Germ cells are thought to exhibit a unique DNA damage response that differs from that of somatic stem cells, and previous studies suggested that Trp53 is not involved in the survival of spermatogonial stem cells (SSCs) after irradiation.
Kei Ishii +6 more
doaj +1 more source
Cells, 2020 Radiation-induced damage is a common occurrence in cancer patients who undergo radiotherapy. In this setting, radiation-induced damage can be refractory because the regeneration responses of injured tissues or organs are not well stimulated.
Xiaoyu Pu +5 more
doaj +1 more source
Cullin Ring Ubiquitin Ligases (CRLs) in Cancer: Responses to Ionizing Radiation (IR) Treatment
Frontiers in Physiology, 2019 Treatment with ionizing radiation (IR) remains the cornerstone of therapy for multiple cancer types, including disseminated and aggressive diseases in the palliative setting. Radiotherapy efficacy could be improved in combination with drugs that regulate
Shahd Fouad +3 more
doaj +1 more source
Biomarkers of aging associated with past treatments in breast cancer survivors. [PDF]
, 2017 Radiation and chemotherapy are effective treatments for cancer, but are also toxic to healthy cells. Little is known about whether prior exposure to these treatments is related to markers of cellular aging years later in breast cancer survivors.
Bower, Julienne E +11 more
core +2 more sources