Results 71 to 80 of about 890,751 (309)
FISH comets show that the salvage enzyme TK1 contributes to gene-specific DNA repair
Frontiers in Genetics, 2014 Thymidine kinase 1 (TK1) is a salvage enzyme that phosphorylates thymidine, imported from surrounding fluids, to create dTMP, which is further phosphorylated to the DNA precursor dTTP.
Stephen eDownes +6 more
doaj +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Fixed-target serial oscillation crystallography at room temperature
IUCrJ, 2019 A fixed-target approach to high-throughput room-temperature serial synchrotron crystallography with oscillation is described. Patterned silicon chips with microwells provide high crystal-loading density with an extremely high hit rate.
Jennifer L. Wierman +16 more
doaj +1 more source
The radiation damage workshop considered a variety of topics among which were the need for equivalent electron fluences in gallium arsenide, the possibility of 15 percent end-of-life efficiencies for silicon, increasing radiation resistance in gallium ...
Weinberg, I.
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Journal of Translational MedicineBackground Radiotherapy is a central modality in cancer management, yet intrinsic and acquired radioresistance and dose-limiting normal tissue toxicities continue to constrain durable tumor control.
Xiaoli Lv +7 more
doaj +1 more source
Nuclear Engineering and TechnologyEvaluating radiation damage in materials and devices is vital for their use in extreme environments, but accurate predictions are challenging due to uncertainties in traditional models like Primary Radiation Damage Models (PRDMs) and modern simulations ...
Zulfiqar Ali +5 more
doaj +1 more source
Radiation damage in small-molecule crystallography: fact not fiction
IUCrJ, 2019 Traditionally small-molecule crystallographers have not usually observed or recognized significant radiation damage to their samples during diffraction experiments.
Jeppe Christensen +6 more
doaj +1 more source
Exploratory Materials Science Research, 2020 The damage induced in cerium dioxide or ceria by charged particle irradiations was investigated by various spectroscopic techniques, such as Raman spectroscopy, electron paramagnetic resonance (EPR) spectroscopy, and UV-visible absorption/reflection spectroscopy.
openaire +1 more source
Gd or Sm doped silicon semiconductor composition Patent [PDF]
, 1968 Gadolinium or samarium doped-silicon semiconductor material with resistance to radiation damage for use in solar ...
Mandelkorn, J.
core +1 more source