Results 51 to 60 of about 327,150 (263)

RADIATION RESISTANCE OF COMPOSITE SCINTILLATORS

Problems of Atomic Science and Technology, 2019
Radiation resistance of composite scintillators containing grains of organic or inorganic single crystals has been analysed. The analysis is based on the study of composite scintillators containing grains Gd2SiO5:Ce (GSO:Ce), Gd2Si2O7:Ce (GPS:Ce), Al2O3:Ti, Y2SiO5:Ce (YSO:Ce) or Y3Al5O12:Ce (YAG:Ce).
Boyarintsev, A.Yu., Galunov, N.Z., Gerasymov, Ia.V., Gorbacheva, T.E., Grinyov, B.V., Karavaeva, N.L., Khabuseva, S.U., Krech, A.V., Levchuk, L.G., Martynenko, E.V., Popov, V.F., Sidletskiy, O.Ts., Tarasenko, O.A.   +12 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Application of numerical methods to determine some parameters of radiation embrittlement of borosilicate glass

Қарағанды университетінің хабаршысы. Физика сериясы
In this paper, a numerical method for determining the parameters of radiation embrittlement in borosilicate glass is proposed. The method is based on analyzing the changes in the mechanical properties of the material atoms, the fluence Ф and the energy ...
Sh. M. Kazhykenov, G. U. Yerbolatova, A. K. Tussupbekova   +2 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Circuit Modeling of the Impact of Heavy Charged Particles on Transient Processes in Bipolar Analog Microcircuits

Доклады Белорусского государственного университета информатики и радиоэлектроники
One of the factors causing the failure of spacecraft integrated circuits is exposure to heavy charged particles. The entry of heavy charged particles into electronic devices leads to the appearance of single event transients (short current pulses), which
O. V. Dvornikov, V. A. Tchekhovski, I. Yu. Lovshenko, Trong Thanh Nguyen   +3 more
doaj   +1 more source

DNA Damage Protection for Enhanced Bacterial Survival Under Simulated Low Earth Orbit Environmental Conditions in Escherichia coli

Frontiers in Microbiology, 2021
Some organisms have shown the ability to naturally survive in extreme environments, even outer space. Some of these have natural mechanisms to resist severe DNA damage from conditions such as ionizing and non-ionizing radiation, extreme temperatures, and
Jaume Puig, Jaume Puig, Nastassia Knödlseder, Nastassia Knödlseder, Jaume Quera, Jaume Quera, Jaume Quera, Manuel Algara, Manuel Algara, Manuel Algara, Marc Güell, Marc Güell   +11 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

EpCAM-Mediated Cellular Plasticity Promotes Radiation Resistance and Metastasis in Breast Cancer

Frontiers in Cell and Developmental Biology, 2021
Substantial number of breast cancer (BC) patients undergoing radiation therapy (RT) develop local recurrence over time. During RT therapy, cells can gradually acquire resistance implying adaptive radioresistance.
Arijit Mal, Arijit Mal, Amirali B. Bukhari, Ram K. Singh, Aastha Kapoor, Amlan Barai, Ishan Deshpande, Tabassum Wadasadawala, Pritha Ray, Pritha Ray, Shamik Sen, Abhijit De, Abhijit De   +12 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

miRNA‐106a and prostate cancer radioresistance: a novel role for LITAF in ATM regulation

Molecular Oncology, 2018
Recurrence of high‐grade prostate cancer after radiotherapy is a significant clinical problem, resulting in increased morbidity and reduced patient survival.
Christianne Hoey, Jessica Ray, Jouhyun Jeon, Xiaoyong Huang, Samira Taeb, Jarkko Ylanko, David W. Andrews, Paul C. Boutros, Stanley K. Liu   +8 more
doaj   +1 more source