Results 51 to 60 of about 349,910 (312)

SELECTION FOR RADIATION RESISTANCE IN MICE [PDF]

Genetics, 1963
From a four-way cross of inbred strains of mice, two separate selection experiments were performed: two-way selection for survival under 100 r/day of x rays and twoway selection for survival under 400 r/day of x rays. Selection was successful in both experiments but was much more pronounced under 100 r/day.
openaire   +2 more sources

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Factors and molecular mechanisms of radiation resistance in cancer cells [PDF]

, 2022
https://openpolicyfinder.jisc.ac.uk/id/publication/911Purpose: The aim of this work is to review the published studies on radiation resistance mechanisms and molecular markers involved in different tumors.
González Vidal, Alejandro, Alamilla Presuel, Juan Carlos, Sendra-Portero, Francisco, Ruiz-Gómez, Miguel José, Burgos-Molina, Antonio Manuel   +4 more
core   +1 more source

Effect of graphene quantum dots on the radiation resistance of epoxy resin

Fushe yanjiu yu fushe gongyi xuebao
Investigations on the damage and degradation mechanisms of epoxy resin under a high-energy irradiation and improvement in its stability in irradiation environments are crucial to expand the application of epoxy resin in numerous fields including the ...
HOU Jinxia, LIU Shengkai, PEI Xiaoyuan, WANG Wei, YIN Yue, ZHOU Xinke, XU Zhiwei   +6 more
doaj   +1 more source

Cetuximab enhances radiosensitivity of esophageal squamous cell carcinoma cells by G2/M cycle arrest and DNA repair delay through inhibiting p‐EGFR and p‐ERK

Thoracic Cancer, 2023
Background Although radiotherapy has improved local control in esophageal squamous cell carcinoma (ESCC), a considerable number of patients still experience relapse due to resistance.
Guifang Zhao, Liwen Feng, Ting Ye, Yanshen Liu, Li Fan, Chengzhi Ye, Jing Chen   +6 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

"Adaptive response" - some underlying mechanisms and open questions [PDF]

, 2008
Organisms are affected by different DNA damaging agents naturally present in the environment or released as a result of human activity. Many defense mechanisms have evolved in organisms to minimize genotoxic damage. One of them is induced radioresistance
Stephka G. Chankova, Dimova, Evgeniya G, Chankova, Stephka G, Peter E. Bryant, Bryant, Peter Edward, Evgeniya G. Dimova   +5 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Genomic Insights into the Radiation-Resistant Capability of Sphingomonas qomolangmaensis S5-59^T and Sphingomonas glaciei S8-45^T, Two Novel Bacteria from the North Slope of Mount Everest

Microorganisms, 2022
Mount Everest provides natural advantages to finding radiation-resistant extremophiles that are functionally mechanistic and possess commercial significance.
Yang Liu, Xiaowen Cui, Ruiqi Yang, Yiyang Zhang, Yeteng Xu, Guangxiu Liu, Binglin Zhang, Jinxiu Wang, Xinyue Wang, Wei Zhang, Tuo Chen, Gaosen Zhang   +11 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source