Results 111 to 120 of about 4,478 (181)
Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca +6 more
wiley +1 more source
Abstract Background Prostate cancer (PCa) patients frequently experience biochemical recurrence (BCR) following definitive primary treatment. Although fluorine‐18–labeled prostate‐specific membrane antigen positron emission tomography/computed tomography (18F‐PSMA PET/CT) is an imaging modality that is highly sensitive for BCR, false‐positive findings ...
Ioanna Stamouli +10 more
wiley +1 more source
ABSTRACT Purpose To characterize the diffusion properties of prostate epithelium and stroma in benign tissue and cancer. Methods Paired MR microscopy (20 μm) and multidimensional diffusion MRI (dMRI) (160 μm, b = 1000–2000 s/mm2, ∆ = 15–120 ms) were performed at 16.4 T on 17 fixed prostate tissue samples (14× benign, 2× Gleason 3 + 3, 1× Gleason 4 + 4).
Adam Phipps +7 more
wiley +1 more source
Magnetic Resonance Imaging at 14 Tesla of Prostate Biopsies Obtained after Prostatectomy
Fresh prostate biopsies were imaged using a 14 T vertical bore MRI scanner, and the effects of long gradient separation Δ (10–400 ms) were explored. At Δ longer than 10 ms, the percentage of voxels where the Akaike information criteria (AICc) favored a monoexponential model increased, and the apparent diffusion coefficient (ADC) lowered compared to Δ ...
Fredrik Langkilde +4 more
wiley +1 more source
ABSTRACT Background The management of intermediate‐risk early prostate cancer (PCa) is challenging due to the difficulty in distinguishing indolent from aggressive tumors. This study explores the association between genomic alterations and the tumor and its microenvironment (TME) and implications for disease progression. Methods We performed multi‐omic
William Lautert‐Dutra +13 more
wiley +1 more source
ABSTRACT Background Hypofractionated salvage radiotherapy is increasingly used for biochemical recurrence of prostate cancer post‐prostatectomy, yet its toxicity profile remains underexplored. This study evaluates the incidence, timing, and resolution of treatment‐related toxicities in this setting.
Bum‐Sup Jang +2 more
wiley +1 more source
Lipid and Foam Cell Accumulation as Novel Pathological Features of Benign Prostatic Hyperplasia
ABSTRACT Background Benign prostatic hyperplasia (BPH) encompasses a heterogeneous set of pathological processes that instigate lower urinary tract symptoms (LUTS). Using a mouse model of steroid hormone imbalance–induced lower urinary tract dysfunction, we identified luminal lipid‐laden foamy macrophages, although their presence and contribution to ...
Dita Julianingsih +9 more
wiley +1 more source
Focal therapy using a novel cooled laser device for prostate cancer: early trial results
Objectives To determine the short‐term oncological results and safety of the ProFocal Laser Therapy for Prostate Tissue Ablation (PFLT‐PC) trial, the first phase II clinical trial of ProFocal® (Medlogical Innovations, Sydney, Australia), a novel, cooled laser focal therapy (cLFT) device for prostate cancer (PCa) treatment. Patients and Methods Men with
Jonathan Kam +17 more
wiley +1 more source
Objective To describe the development and validation of the Prostate Cancer Electronic Health (eHealth) Literacy Instrument (P‐CeHLI). This is in response to: (i) a lack of clear and validated eHealth literacy measurement for men with prostate cancer; (ii) the unique information processing, decision making, and digital communication experience of men ...
Stuart Robert Jackson +6 more
wiley +1 more source
Objective To systematically evaluate management strategies and associated outcomes of iatrogenic ureteric injuries, focusing on clinical success, renal unit loss, and the need for subsequent endoscopic or reconstructive procedures. Patients and Methods A pre‐registered protocol (CRD420251184018) guided a comprehensive search of PubMed and EMBASE ...
Pietro Scilipoti +17 more
wiley +1 more source

