Aryl trimethylammonium trifluoromethanesulfonates as precursors to aryl [18F]fluorides [PDF]
, 1989 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90143/1/2580260109_ftp ...
Angelini +6 more
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Chemistry – A European Journal, Volume 30, Issue 55, October 1, 2024.A method was rationally optimized to minimize deleterious protodeboronation side‐product in Cu‐mediated 19F‐ and 18F‐fluorination of arylboronic acids. Fluoride anion is activated through a hydrogen bond donor (HBD) effect under ligandless conditions featuring a new copper salt, Cu(ONf)2.
Jingkai Sun +3 more
wiley +1 more source
Rapid Electrophilic 211At‐Astatination of Trimethylgermyl Arenes
ChemPlusChem, Volume 89, Issue 9, September 2024.211At‐Astatodegermylation: Different ortho‐, meta‐, and para‐substituted trimethylgermyl arenes were astatinated at low precursor amounts (0.15 μmol) in trifluoroacetic acid with an average radiochemical conversion (RCC) of ca. 50 % for electron‐rich and approx. 70 % in case of electron‐deficient arenes.
Marius Müller +7 more
wiley +1 more source
Automated radiosynthesis of Al[18F]PSMA-11 for large scale routine use. [PDF]
, 2018 Objectives: We report a reproducible automated radiosynthesis for large scale batch production of clinical grade Al[F-18]PSMA-11. Methods: A SynthraFCHOL module was optimized to synthesize Al[F-18]PSMA-11 by Al[F-18]-chelation.
Brans, Boudewijn +7 more
core +1 more source
Potential of miRNA as Imaging Targets for PET
Helvetica Chimica Acta, Volume 107, Issue 8, August 2024.Abstract Positron Emission Tomography (PET) is an important part of the medical imaging field which is continually exploring novel biological targets as exemplified by PET imaging of neuroinflammation. Due to limitations stemming from either sub‐optimal biological targets or a lack of available selective radiotracers, alternative biomarkers and PET ...
Simon H. Zientek +3 more
wiley +1 more source
Zur Synthese von 6[18F]Fluor-L-DOPA durch nukleophile 18F-Fluorierung Carbonyl-aktivierter aromatischer Aminosäurederivate [PDF]
, 2001 6-[$^{18}$F]Fluoro-L-3,4-dihydroxyphenylalanine (6-[$^{18}$F]fluoro-L-DOPA), an analogue of L-DOPA, is an established radiotracer for diagnostic PET-studies of the integrity and function of the nigrostriatal dopaminergic system. The use of this important
Tierling, Thomas
core
Molecules, 2012 The semisynthetic oripavine derivative phenethyl orvinol (PEO), a full agonist at opioid receptors (OR), is an attractive structural motif for developing 18F-labeled PET tracers with a high degree of sensitivity for competition between endogenous and ...
Gjermund Henriksen, János Marton
doaj +1 more source
Late-Stage Copper-Catalyzed Radiofluorination of an Arylboronic Ester Derivative of Atorvastatin
Molecules, 2019 There is an unmet need for late-stage 18F-fluorination strategies to label molecules with a wide range of relevant functionalities to medicinal chemistry, in particular (hetero)arenes, aiming to obtain unique in vivo information on the pharmacokinetics ...
Gonçalo S. Clemente +3 more
doaj +1 more source
[18F]DPA-714 as a biomarker for positron emission tomography imaging of rheumatoid arthritis in an animal model. [PDF]
, 2014 International audienceINTRODUCTION: Rheumatoid arthritis (RA) is a chronic disease, affecting 0.5-1% of adults in industrialized countries, in which systemic inflammation and synovitis drive joint destruction.
Bernards, Nicholas +3 more
core +4 more sources
Scalable 18F Processing Conditions for Copper-Mediated Radiofluorination Chemistry Facilitate "Design of Experiments" (DoE) Optimization Studies and Afford an Improved Synthesis of [18F]Olaparib. [PDF]
, 2021 Gregory D. Bowden +3 more
openalex +2 more sources