Results 101 to 110 of about 3,410 (215)
Brain‐X, Volume 2, Issue 1, March 2024.We have developed a novel PET tracer, [18F]GSK1482160, and verified its permeability and stability to the blood‐brain barrier (BBB) in both rodents and non‐human primates using PET imaging techniques. The correlation between the binding of [18F]GSK1482160 and Morris water maze (MWM) behavioral analysis suggests that neuroinflammatory regions are ...
Yifan Qiu +18 more
wiley +1 more source
EJNMMI Radiopharmacy and Chemistry, 2020 Background Oncrasin-1 is a small molecule which was identified from a screen of KRAS mutant cancer cells and has shown specificity for KRAS mutant cell killing.
Alexander F. McDonald +4 more
doaj +1 more source
Automated synthesis of PET radiotracers by copperâ mediated 18Fâ fluorination of organoborons: Importance of the order of addition and competing protodeborylation [PDF]
, 2018 Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142980/1/jlcr3583_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142980/2/jlcr3583 ...
Bailey, Justin J. +7 more
core +1 more source
Fluorination of organoboron compounds [PDF]
, 2019 Methods for the fluorination of organoboron compounds are described. This review will cover the fluorination of aromatic and aliphatic systems using both electrophilic and nucleophilc sources of fluorine.
Pattison, Graham
core +2 more sources
Molecules, 2013 With the idea of finding a more selective radiotracer for imaging herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene expression by means of positron emission tomography (PET), a novel [18F]fluorine radiolabeled pyrimidine with 4-hydroxy-3 ...
Simon M. Ametamey +6 more
doaj +1 more source
Synthesis and evaluation of 18F-labeled inhibitors for targeting mutant isocitrate dehydrogenase 1 (mIDH1) [PDF]
, 2023 PET is a fundamental imaging method used for in vivo visualization of physiological and pathophysiological processes on the molecular level. This technique relies on radiotracers, which consist of a pharmacophore addressing the biological target of ...
Cologni, Roberta
core
Sulfonium Salts as Leaving Groups for Aromatic Labelling of Drug-like Small Molecules with Fluorine-18. [PDF]
Positron emission tomography (PET) is unique in that it allows quantification of biochemical processes in vivo, but difficulties with preparing suitably labelled radiotracers limit its scientific and diagnostic applications.
Cybulska, K +6 more
core
Improved synthesis of 4-[18F]fluoro-m-hydroxyphenethylguanidine using an iodonium ylide precursor [PDF]
, 2019 Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/151961/1/jlcr3791.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/151961/2/jlcr3791_am ...
Gu, Guie +2 more
core +1 more source
Peripheral ganglia in healthy rats as target structures for the evaluation of PSMA imaging agents
BMC Cancer, 2019 Background The recent implementation of PET with prostate specific membrane antigen (PSMA)-specific radiotracers into the clinical practice has resulted in the significant improvement of accuracy in the detection of prostate carcinoma (PCa).
Heike Endepols +8 more
doaj +1 more source