Results 1 to 10 of about 15,914 (251)

Chemotherapy synergizes with radioimmunotherapy targeting La autoantigen in tumors. [PDF]

PLoS ONE, 2009
To date, inefficient delivery of therapeutic doses of radionuclides to solid tumors limits the clinical utility of radioimmunotherapy. We aim to test the therapeutic utility of Yttrium-90 ((90)Y)-radio-conjugates of a monoclonal antibody, which we showed
Fares Al-Ejeh, Jocelyn M Darby, Michael P Brown   +2 more
doaj   +3 more sources

Pathogen-Specific Actinium-225 and Lutetium-177 Labeled Antibodies for Treatment of Biofilm-Associated Implant Infections: Initial In Vivo Proof-of-Concept [PDF]

Antibiotics
Background: the primary challenge with implant infections is the formation of biofilm, which harbors dormant bacteria that reduce the effectiveness of antibiotics and amplify antibiotic resistance, exacerbating the global antimicrobial resistance crisis.
F. Ruben H. A. Nurmohamed, Kevin J. H. Allen, Mackenzie E. Malo, Connor Frank, J. Fred F. Hooning van Duvenbode, Berend van der Wildt, Alex J. Poot, Marnix G. E. H. Lam, Jos A. G. van Strijp, Peter G. J. Nikkels, H. Charles Vogely, Harrie Weinans, Ekaterina Dadachova, Bart C. H. van der Wal   +13 more
doaj   +2 more sources

Multifunctional nanoagent for enhanced cancer radioimmunotherapy via pyroptosis and cGAS-STING activation [PDF]

Journal of Nanobiotechnology
The immunosuppressive tumor microenvironment (ITME) and inherent radioresistance of tumor cells limit the effectiveness of radioimmunotherapy and exacerbate immune evasion.
Ziting Xu, Yang Gao, Li Zhang, Yingshan Gao, Yushu Liao, Yu Liang, Zhen Yuan, Yingjia Li, Bingxia Zhao, Ge Wen   +9 more
doaj   +2 more sources

Nanosensitizer for Cancer Radioimmunotherapy via Anti‐IL‐35 Blockade Boosted Innate Immunity Activation [PDF]

Advanced Science
The cGAS‐STING signaling pathway has emerged as a promising target for cancer immunotherapy. However, STING agonists have a dual‐edged nature. Although they enhance antitumor T cell activity, STING agonists also elicit protumorigenic effects by promoting
Yinfei Zheng, Shuting Zheng, Yushu Liao, Zede Wu, Chenxi He, Qiuyu Li, Honglei Hu, Zheyu Shen, Yikai Xu, Chenggong Yan, Bingxia Zhao, Meirong Hou   +11 more
doaj   +2 more sources

Radioimmunotherapy combating biofilm-associated infection in vitro [PDF]

Frontiers in Medicine
BackgroundAddressing prosthetic joint infections poses a significant challenge within orthopedic surgery, marked by elevated morbidity and mortality rates. The presence of biofilms and infections attributed to Staphylococcus aureus (S.
Zijian Ye, Berend van der Wildt, F. Ruben H. A. Nurmohamed, J. Fred F. Hooning van Duyvenbode, Jos van Strijp, H. Charles Vogely, Marnix G. E. H. Lam, Ekaterina Dadachova, Harrie Weinans, Harrie Weinans, Bart C. H. van der Wal, Alex J. Poot   +11 more
doaj   +2 more sources

Optimizing Cancer Treatment: Exploring the Role of AI in Radioimmunotherapy [PDF]

Diagnostics
Radioimmunotherapy (RIT) is a novel cancer treatment that combines radiotherapy and immunotherapy to precisely target tumor antigens using monoclonal antibodies conjugated with radioactive isotopes.
Hossein Azadinejad, Mohammad Farhadi Rad, Ahmad Shariftabrizi, Arman Rahmim, Hamid Abdollahi   +4 more
doaj   +2 more sources

DNA-PKcs Dysfunction Enhances the Antitumor Activity of Radioimmunotherapy by Activating the cGAS-STING Pathway in HNSCC [PDF]

Journal of Inflammation Research
Lizhu Chen,1– 3,* Jing Lin,1– 3,* Yaoming Wen,4,* Zeng-Qing Guo,1– 3,* Bin Lan,2,3 Jiani Xiong,1– 3 Chuan-Ben Chen,2,3,5 Yu Chen1– 3 1Department of Medical Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer ...
Chen L, Lin J, Wen Y, Guo ZQ, Lan B, Xiong J, Chen CB, Chen Y   +7 more
doaj   +2 more sources

Radioimmunotherapy for solid tumors: spotlight on Glypican-1 as a radioimmunotherapy target

Therapeutic Advances in Medical Oncology, 2021
Radioimmunotherapy (i.e., the use of radiolabeled tumor targeting antibodies) is an emerging approach for the diagnosis, therapy, and monitoring of solid tumors.
Dhanusha Sabanathan, Maria E. Lund, Douglas H. Campbell, Bradley J. Walsh, Howard Gurney   +4 more
doaj   +1 more source

Tellurium-driven maple leaf-shaped manganese nanotherapeutics reshape tumor microenvironment via chemical transition in situ to achieve highly efficient radioimmunotherapy of triple negative breast cancer

Bioactive Materials, 2023
The therapeutic efficacy of radioimmunotherapy against triple negative breast cancer (TNBC) is largely limited by the complicated tumor microenvironment (TME) and its immunosuppressive state.
Wei Huang, Sujiang Shi, Haoran Lv, Zhenyu Ju, Qinghua Liu, Tianfeng Chen   +5 more
doaj   +1 more source

Cancer Radioimmunotherapy [PDF]

Immunotherapy, 2011
Targeting of radionuclides with antibodies, or radioimmunotherapy, has been an active field of research spanning nearly 50 years, evolving with advancing technologies in molecular biology and chemistry, and with many important preclinical and clinical studies illustrating the benefits, but also the challenges, which all forms of targeted therapies face.
Robert M, Sharkey, David M, Goldenberg
openaire   +2 more sources