177Lu Anti-Angiogenic Radioimmunotherapy Targeting ATP Synthase in Gastric Cancer Model [PDF]
AntibodiesThis study investigated a novel radioimmunotherapy strategy for targeting tumor angiogenesis. We developed a radiopharmaceutical complex by labeling an anti-adenosine triphosphate synthase (ATPS) monoclonal antibody (mAb) with the radioisotope 177Lu ...
Bok-Nam Park +5 more
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Pharmaceuticals, 2019 The development of monoclonal antibodies has dramatically changed the outcome of patients with non-Hodgkin’s lymphoma (NHL), the most common hematological malignancy.
Christos Sachpekidis +2 more
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Optimizing Cancer Treatment: Exploring the Role of AI in Radioimmunotherapy [PDF]
DiagnosticsRadioimmunotherapy (RIT) is a novel cancer treatment that combines radiotherapy and immunotherapy to precisely target tumor antigens using monoclonal antibodies conjugated with radioactive isotopes.
Hossein Azadinejad +4 more
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Radioimmunotherapy combating biofilm-associated infection in vitro [PDF]
Frontiers in MedicineBackgroundAddressing prosthetic joint infections poses a significant challenge within orthopedic surgery, marked by elevated morbidity and mortality rates. The presence of biofilms and infections attributed to Staphylococcus aureus (S.
Zijian Ye +11 more
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DNA-PKcs Dysfunction Enhances the Antitumor Activity of Radioimmunotherapy by Activating the cGAS-STING Pathway in HNSCC [PDF]
Journal of Inflammation ResearchLizhu Chen,1– 3,* Jing Lin,1– 3,* Yaoming Wen,4,* Zeng-Qing Guo,1– 3,* Bin Lan,2,3 Jiani Xiong,1– 3 Chuan-Ben Chen,2,3,5 Yu Chen1– 3 1Department of Medical Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer ...
Chen L +7 more
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Antibody conjugates in neuroblastoma: a step forward in precision medicine [PDF]
Frontiers in OncologyNeuroblastoma (NB) is a pediatric cancer that often manifests in a high-risk form and is characterized by frequent relapses and resistance to conventional therapies.
Jihane Balla +5 more
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A biomathematical model of tumor response to radioimmunotherapy with $α$PDL1 and $α$CTLA4 [PDF]
IEEE/ACM Transactions on Computational Biology and Bioinformatics
2023;20:808-821, 2021 There is evidence of synergy between radiotherapy and immunotherapy. Radiotherapy can increase liberation of tumor antigens, causing activation of antitumor T-cells. This effect can be boosted with immunotherapy. Radioimmunotherapy has potential to increase tumor control rates.
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Radioimmunotherapy in colorectal cancer treatment: present and future
Frontiers in Immunology, 2023 Colorectal cancer (CRC) is a deadly form of cancer worldwide. Patients with locally advanced rectal cancer and metastatic CRC have a poor long-term prognosis, and rational and effective treatment remains a major challenge. Common treatments include multi-
Jingyi Shi +5 more
semanticscholar +1 more source
Radioimmunotherapy for solid tumors: spotlight on Glypican-1 as a radioimmunotherapy target
Therapeutic Advances in Medical Oncology, 2021 Radioimmunotherapy (i.e., the use of radiolabeled tumor targeting antibodies) is an emerging approach for the diagnosis, therapy, and monitoring of solid tumors.
Dhanusha Sabanathan +4 more
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Chemotherapy synergizes with radioimmunotherapy targeting La autoantigen in tumors. [PDF]
PLoS ONE, 2009 To date, inefficient delivery of therapeutic doses of radionuclides to solid tumors limits the clinical utility of radioimmunotherapy. We aim to test the therapeutic utility of Yttrium-90 ((90)Y)-radio-conjugates of a monoclonal antibody, which we showed
Fares Al-Ejeh +2 more
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