A Standard Operating Procedure (SOP) has been formulated for in-house preparation, quality control, dispensing and administration of 131 I-rituximab appropriate for the safe, effective, radioimmunotherapy of non-Hodgkin lymphoma.
Matthew Pickford, J. Turner
doaj +1 more source
Excitation functions of proton induced nuclear reactions on natW up to 40 MeV [PDF]
Excitation functions for the production of the 181,182m,182g,183,184g,186Re and 183,184Ta radionuclides from proton bombardment on natural tungsten were measured using the stacked-foil activation technique for the proton energies up to 40 MeV. A new data
Akkermans +40 more
core +2 more sources
Pretargeted radioimmunotherapy: clinically more efficient than conventional radioimmunotherapy? [PDF]
The clinical efficacy of radioimmunotherapy (RIT) has been clearly documented in the consolidation situation, such as first-line treatment of indolent non-Hodgkin lymphoma after induction chemotherapy [1] or after salvage resection of liver metastases from colon carcinoma [2], when tumour targets have a small, preferably microscopic, size. Efficacy has
Caroline, Rousseau +3 more
openaire +2 more sources
Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity 86Y- or 177Lu-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates [PDF]
Purpose: GPA33 is a colorectal cancer (CRC) antigen with unique retention properties after huA33-mediated tumor targeting. We tested a pretargeted radioimmunotherapy (PRIT) approach for CRC using a tetravalent bispecific antibody with dual specificity ...
Carrasquillo, Jorge A. +14 more
core +1 more source
Radiation-induced chromosomal aberrations represent an early marker of late effects, including cell killing and transformation. The measurement of cytogenetic damage in tissues, generally in blood lymphocytes, from patients treated with radiotherapy has ...
Marco Durante, Silvia C. Formenti
doaj +1 more source
The prognosis of advanced malignant tumors is very poor, and effective treatment is limited. Radioimmunotherapy (RIT) is a novel treatment method. However, its anti-tumor effect is relatively low in solid tumors, which is mainly due to the blood-tumor ...
Binwei Lin +9 more
doaj +1 more source
Re-188 Enhances the Inhibitory Effect of Bevacizumab in Non-Small-Cell Lung Cancer
The malignant behaviors of solid tumors such as growth, infiltration and metastasis are mainly nourished by tumor neovascularization. Thus, anti-angiogenic therapy is key to controlling tumor progression.
Jie Xiao +8 more
doaj +1 more source
Radioimmunotherapy Improves Survival of Rats with Microscopic Liver Metastases of Colorectal Origin [PDF]
BACKGROUND: Half of the patients with colorectal cancer develop liver metastases during the course of their disease. The aim of the present study was to assess the efficacy of radioimmunotherapy (RIT) with a radiolabeled monoclonal antibody (mAb) to ...
Gabie M. de Jong +33 more
core +1 more source
Comparison of I-131 Radioimmunotherapy Tumor Dosimetry: Unit Density Sphere Model Versus Patient-Specific Monte Carlo Calculations [PDF]
High computational requirements restrict the use of Monte Carlo algorithms for dose estimation in a clinical setting, despite the fact that they are considered more accurate than traditional methods.
Bolch WE +13 more
core +1 more source
RADIOIMMUNOTHERAPY IN THE TREATMENT OF MALIGNANCIES
This review presents information about one of the promising areas of targeted therapy in modern oncology, which is called radioimmunotherapy. Particular attention is paid to the possibility of clinical application of this type of systemic treatment for ...
V. I. Chernov +4 more
doaj +1 more source

