Results 101 to 110 of about 87,481 (331)

\u3csup\u3e99m\u3c/sup\u3eTc-Labeled C2A Domain of Synaptotagmin I as a Target-Specific Molecular Probe for Noninvasive Imaging of Acute Myocardial Infarction [PDF]

, 2006
: The exposure of phosphatidylserine (PtdS) is a common molecular marker for both apoptosis and necrosis and enables the simultaneous detection of these distinct modes of cell death. Our aim was to develop a radiotracer based on the PtdS-binding activity
Fang, Wei, Hellman, Robert S., Ji, Shundong, Molthen, Robert C., Ozker, Kutlan S., Zhao, Ming, Zhou, Jundong, Zhu, Xiaoguang   +7 more
core   +1 more source

Synthesis of Fluorine-18 Functionalized Nanoparticles for use as in vivo Molecular Imaging Agents [PDF]

, 2008
Nanoparticles containing fluorine-18 were prepared from block copolymers made by ring opening metathesis polymerization (ROMP). Using the fast initiating ruthenium metathesis catalyst (H_2IMes)(pyr)_2(Cl)_2Ru=CHPh, low polydispersity amphiphilic block ...
, X. K., A. Guo, A. M. Morawski, A. M. Smith, C. C. Lee, C. Slugovc, C. W. Bielawski, C. W. Bielawski, D. F. Baban, D. W. Bartlett, E. D. Pressly, E. M. Jagoda, E. M. Rohren, F. Henselwood, F. M. Menger, G. J. Liu, H. A. Nabi, H. D. Maynard, H. Kobayashi, H. Maeda, H. Maeda, H. R. Ihre, I. Brigger, J. A. Love, J. B. Matson, J. Heidel, J. R. Heath, K. D. Camm, K. Fukukawa, L. Cai, L. H. Reddy, M. F. Ilker, M. Ferrari, M. L. Adams, M. L. Schipper, M. Licciardi, M. Rawat, N. K. Jain, N. Malik, R. Gref, R. Sinha, S. K. Hobbs, S. M. Lee, S. M. Moghimi, T. L. Choi, V. Bagalkot, V. P. Tochilin, V. P. Torchilin, V. P. Torchilin, V. P. Torchilin, W. J. M. Mulder, W. S. Seo, X. Michalet, Y. Matsumura, Z. Yang   +54 more
core   +3 more sources

Multicharged Zwitterions form Superior Antifouling Interfaces

Advanced Science, EarlyView.
Bolaamphiphilic multicharged sulfobetaine zwitterion forms self‐assembled monolayer for antifouling applications and vesicular aggregates for drug delivery applications. Abstract The long‐term prevention of unwanted protein and microbial accumulation on surfaces, including medical devices, remains a significant and largely unresolved challenge. Decades
Declan Meehan, Jessica McMaster, Ayantika Kundu, Matthew P. Wylie, Joseph S. Vyle, Karl J. Hale, Marijana Blesic   +6 more
wiley   +1 more source

Preclinical efficacy of hK2 targeted [177Lu]hu11B6 for prostate cancer theranostics [PDF]

, 2019
Androgen ablating drugs increase life expectancy in men with metastatic prostate cancer, but resistance inevitably develops. In a majority of these recurrent tumors, the androgen axis is reactivated in the form of increased androgen receptor (AR ...
Beattie, Bradley J., Beattie, Kai A., Elgqvist, Jörgen, Eriksson, Sophie E., Larsson, Erik, Strand, Sven-Erik, Thorek, Daniel L. J., Timmermand, Oskar Vilhelmsson, Tran, Thuy A., Ulmert, David, Örbom, Anders   +10 more
core   +2 more sources

Targeting the Dynamics Between TAMs and CAR‐T Cells in Solid Tumor Therapies

Advanced Science, EarlyView.
This review highlights the critical role of tumor‐associated macrophages (TAMs) in affecting CAR‐T cell therapy effectiveness in solid tumors. TAMs contribute to immune suppression through cytokine secretion, immune checkpoint activation, and metabolic reprogramming, leading to CAR‐T cell exhaustion and reduced efficacy. The article explores strategies
Xiang Zhang, Hao Zheng, Zi‐Chang Liu, Ling‐Jie Luo, Xiao Dong, Xin‐Gang Cui, Yan‐Wei Wu, Liang Chen   +7 more
wiley   +1 more source

New amino bisphosphonate compound for skeletal imaging: Comparison study with methylenediphosphonic acid (MDP) and (1-hydroxyethane-1,1-diyl) diphosphonic acid (HEDP)

Nukleonika, 2016
A novel bisphosphonate derivative (1-aminoethane-1,1-diyl)diphosphonic acid (AEDP) has been prepared and successfully labeled with 99mTc at high labeling yields.
Assaad Thaer
doaj   +1 more source

A new method for radiolabeling of human immunoglobulin-G and its biological evaluation

Journal of Pharmacy and Bioallied Sciences, 2012
Background: Radiolabeled human Immunoglobulin-G (hIgG) has demonstrated its utility in inflammation and infection imaging. However, the present method of radiolabeling hIgG is time-consuming and complex.
Thakuri Singh, Neeraj Kumar, Sandeep Soni, Harish Rawat, Gaurav Mittal, Ajay K Singh, Aseem Bhatnagar   +6 more
doaj   +1 more source

Pharmacokinetic Study of Oral 14C-Radiolabeled Hyzetimibe, A New Cholesterol Absorption Inhibitor [PDF]

, 2021
Jianwei Liao, Xin Wang, Zhenyu Li, Dongsheng Ouyang   +3 more
openalex   +1 more source

NIR Ratiometric Fluorescent Antibody‐Drug Conjugate for Metastatic Ovarian Cancer Theranostics and Treatment Response Monitoring

Advanced Science, EarlyView.
In vivo optical imaging enhances antibody‐drug conjugate (ADC) optimization by enabling real‐time monitoring of stimulus‐responsive drug behavior. We report n501‐CYMMAF, a ratiometric theranostic with strong target affinity and low‐dose efficacy for ovarian metastasis.
Cheng Li, Zezhong Yu, Tao Pu, Yanling Wu, Gang Wang, Youhua Xie, Tianlei Ying, Zhenlin Yang, Yibing Shi   +8 more
wiley   +1 more source

¹⁷⁷Lu-Labeled Iron Oxide Nanoparticles Functionalized with Doxorubicin and Bevacizumab as Nanobrachytherapy Agents against Breast Cancer

Molecules
The use of conventional methods for the treatment of cancer, such as chemotherapy or radiotherapy, and approaches such as brachytherapy in conjunction with the unique properties of nanoparticles could enable the development of novel theranostic agents ...
Evangelia-Alexandra Salvanou, Argiris Kolokithas-Ntoukas, Danai Prokopiou, Maria Theodosiou, Eleni Efthimiadou, Przemysław Koźmiński, Stavros Xanthopoulos, Konstantinos Avgoustakis, Penelope Bouziotis   +8 more
doaj   +1 more source