Aptamer-based therapeutics and their potential in radiopharmaceutical design [PDF]
, 2007 Aptamers, short, single stranded oligonucleotide entities, have been developed in the past 15 years against a plethora of targets and for a variety of applications.
Ferreira, Catia S. M. +1 more
core +3 more sources
Carbon‐14 Perovskite Betavoltaics Reach Record 10.79% Efficiency
Carbon Energy, EarlyView.A perovskite‐based betavoltaic cell incorporating carbon‐14 nanoparticles and formamidinium lead iodide achieves a record energy conversion efficiency of 10.79%. The device design enhances charge generation through an electron avalanche multiplication mechanism.
Hong Soo Kim +6 more
wiley +1 more source
DOTA chelation through click chemistry enables favorable biodistribution of 89 Zr-radiolabeled antibodies: A comparison with DFO chelation [PDF]
, 2022 Ryota Imura +7 more
openalex +1 more source
Evolved DNAzymes and Stable Activation Chemistry Enable High‐Efficiency DNA Ligation
Chemistry – A European Journal, EarlyView.In vitro selection of pre‐structured DNA libraries and chemical screening of alternative activation groups yielded trans‐acting DNAzymes with faster ligation rates and enhanced DNA substrate stability. The combination of C3S1 DNAzymes and phosphobenzimidazole‐activated DNA substrates provides improved DNA ligation performance, offering promise for ...
Connor Nurmi +3 more
wiley +1 more source
Investigating an organ-targeting platform based on hydroxyapatite nanoparticles using a novel in situ method of radioactive 125Iodine labeling [PDF]
, 2014 In this study, we have investigated the synthesis of nanoparticles of hydroxyapatite (HAp) and hydroxyapatite coated with chitosan (HAp/Ch) and the chitosan-poly-d,l-lactide-co-glycolide polymer blend (HAp/Ch-PLGA) as an organ-targeting system.
Ignjatović, Nenad +4 more
core +3 more sources
Chemistry – A European Journal, EarlyView.G‐quadruplex (G4) folding in DNA is inhibitory to AP endonuclease, although the protein still binds well to G4s. Curiously, partially folded G‐rich sequences, possibly transient hairpins, containing AP are very good substrates for cleavage by APE1. Herein, the enzyme activity and G4 folding are studied in single‐stranded vs. duplex contexts.
Brianna L. Trabucco +2 more
wiley +1 more source
Synthesis of [11C]CX-6258 as a new PET tracer for imaging of Pim kinases in cancer [PDF]
, 2015 The reference standard CX-6258 {(E)-5-chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one, 4a} and its desmethylated precursor N-desmethyl-CX-6258 {(E)-3-((5-(3-(1,4-diazepane-1-carbonyl)phenyl)furan-2-yl ...
Gao, Mingzhang +4 more
core +1 more source
In vivo Non-invasive Imaging of Radio-Labeled Exosome-Mimetics Derived From Red Blood Cells in Mice
Frontiers in Pharmacology, 2018 Exosomes are natural nano-sized membrane vesicles that have garnered recent interest owing to their potential as drug delivery vehicles. Though exosomes are effective drug carriers, their production and in vivo biodistribution are still not completely ...
Prakash Gangadaran +25 more
doaj +1 more source
ChemMedChem, EarlyView.This study uses six small‐molecule inhibitors to evaluate optimal cellular accumulation assay conditions in a 96‐well format with high performance liquid chromatography with tandem mass spectrometry detection. The obtained medium to high‐throughput workflow is suitable for reliably identifying cellular accumulation, valuable for preclinical selection ...
Alina Metzen, Katharina Rox
wiley +1 more source
\u3csup\u3e99m\u3c/sup\u3eTc-Labeled C2A Domain of Synaptotagmin I as a Target-Specific Molecular Probe for Noninvasive Imaging of Acute Myocardial Infarction [PDF]
, 2006 : The exposure of phosphatidylserine (PtdS) is a common molecular marker for both apoptosis and necrosis and enables the simultaneous detection of these distinct modes of cell death. Our aim was to develop a radiotracer based on the PtdS-binding activity
Fang, Wei +7 more
core +1 more source