Results 81 to 90 of about 32,685 (264)

Comparative Study of Two Oxidizing Agents, Chloramine T and Iodo-Gen^®, for the Radiolabeling of β-CIT with Iodine-131: Relevance for Parkinson’s Disease

Pharmaceuticals, 2019
Parkinson’s disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, leading to alteration of the integrity of dopaminergic transporters (DATs).
Ana Claudia R. Durante, Danielle V. Sobral, Ana Claudia C. Miranda, Érika V. de Almeida, Leonardo L. Fuscaldi, Marycel R. F. F. de Barboza, Luciana Malavolta   +6 more
doaj   +1 more source

Production, purification, and radiolabeling of the 203Pb/212Pb theranostic pair

, 2021
Background Lead-212 (212Pb, t1/2 = 10.6 h) and lead-203 (203Pb, t1/2 = 51.9 h) are an element-equivalent, or a matched theranostic radioisotope pair that show great potential for application in targeted radionuclide therapy (TRT) and ...
McNeil, Brooke, Ramogida, Caterina F., Fu, Winnie, Yang, Hua, Robertson, Andrew K. H., Hoehr, Cornelia, Schaffer, Paul   +6 more
core   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Development and Radiolabeling Evaluation of 177 Lutetium-Tedizolid

, 1992
Infection diseases is still one of the major health problems all around the world. Early diagnosis and differentiation of infection from other pathological conditions such as cancer and inflammation play a critical role in treating the infection in acute
Argaç, Nurcan, Karpuz, Merve, Özgenç, Emre, Gündoğdu, Evren, Burak, Zeynep   +4 more
core   +1 more source

Rational Design of a Synthetic Galliphore for the Diagnostic Nuclear Imaging and Treatment of Bacterial Infections

Angewandte Chemie International Edition, EarlyView.
KO‐NH2 is a synthetic metallophore that preferentially binds Ga3+ over Fe3+ and is recognized by bacterial transporters. Photocrosslinking identifies CirA and Fiu as key uptake proteins in E. coli. KO‐NH2 enables targeted imaging and treatment of E. coli soft tissue infections.
Phuong Nguyen Tran, Axia Marlin, Edith K. Amason, Marie Huynh, Hannah Carlisle, Eszter Boros   +5 more
wiley   +1 more source

Captivated by Kinesin

Cytoskeleton, EarlyView.
ABSTRACT Few proteins have inspired as much curiosity as kinesin. Since its discovery 40 years ago, kinesin has become one of the best understood molecular machines in biology, yet it continues to reveal new questions about how cells organize and move their contents.
Ronald D. Vale
wiley   +1 more source

Study of radiolabeling of chemically modified bombesines [PDF]

, 2013
STUDY OF RADIOLABELING OF CHEMICALLY MODIFIED BOMBESINES Diploma Thesis Evangelia Saranti Charles University in Prague, Faculty of Pharmacy in Hradec Kralove Department of Biophysics and Physical Chemistry The aim of this thesis was to study the ...
Saranti, Evangelia
core  

Additional file 3: of Radiolabeling polymeric micelles for in vivo evaluation: a novel, fast, and facile method

, 2017
Effect of the indium activity on the radiolabeling efficiency.
Adrianus Laan (3762550), Costanza Santini (3762547), Marion de Jong (121558), Antonia Denkova (2484157), Laurence Jennings (3762553), Monique Bernsen (207681)   +5 more
core   +1 more source

A Fluorine-18 Radiolabeling Method Enabled by Rhenium(I) Complexation Circumvents the Requirement of Anhydrous Conditions [PDF]

, 2017
Azeotropic distillation is typically required to achieve fluorine-18 radiolabeling during the production of positron emission tomography (PET) imaging agents.
Mitchell Klenner (23438215), G. Pascali (23438218), A. Krause-Heuer (23409385), B. Zhang (1597078), T. Sia (23438221), L. Spare (23438224), I. Greguric (23438230), B. Fraser (11985714), Massimiliano Massi (23286109), J. Aldrich-Wright (23438227), A. Guastella (23312416)   +10 more
core   +2 more sources

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development

Epilepsia, EarlyView.
Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source