Results 81 to 90 of about 33,330 (276)

Biodistribution and Lymphatic Tracking of the Main Neurotoxin of Micrurus fulvius Venom by Molecular Imaging

Toxins, 2016
The venom of the Eastern coral snake Micrurus fulvius can cause respiratory paralysis in the bitten patient, which is attributable to β-neurotoxins (β-NTx). The aim of this work was to study the biodistribution and lymphatic tracking by molecular imaging
Irene Vergara, Erick Y. Castillo, Mario E. Romero-Piña, Itzel Torres-Viquez, Dayanira Paniagua, Leslie V. Boyer, Alejandro Alagón, Luis Alberto Medina   +7 more
doaj   +1 more source

Study of radiolabeling of chemically modified bombesines [PDF]

, 2013
STUDY OF RADIOLABELING OF CHEMICALLY MODIFIED BOMBESINES Diploma Thesis Evangelia Saranti Charles University in Prague, Faculty of Pharmacy in Hradec Kralove Department of Biophysics and Physical Chemistry The aim of this thesis was to study the ...
Saranti, Evangelia
core  

Comparative Evaluation of Chelator‐Conjugated Peptides for Lead‐Labeled SSTR2‐Targeted Theranostics: Integrated Computational Modeling and Preclinical Validation

Advanced Science, EarlyView.
The study integrates density functional theory with radiochemical and biological validation to compare DOTA‐, PSC‐, and DOTAM‐based chelator‐conjugates for 203Pb/212Pb theranostic applications. Distinct differences in metal coordination, electrostatic properties, conformational flexibility, cellular uptake, biodistribution, and dosimetry are identified
Jeongyun Kim, Na Yeon Han, Ayman Muzammal, Jae Hun Ahn, Changkeun Im, Sujin Kim, Sairan Eom, Choong Mo Kang, Ku Kang, Yong Jin Lee, Kyo Chul Lee, Michael K. Schultz, Dongyoul Lee   +12 more
wiley   +1 more source

Preparation and 68Ga-radiolabeling of porous zirconia nanoparticle platform for PET/CT-imaging guided drug delivery

, 2017
This paper describes the preparation of gallium-68 (68Ga) isotope labeled porous zirconia (ZrO2) nanoparticle (NP) platform of nearly 100 nm diameter and its first pharmacokinetic and biodistribution evaluation accomplished with a microPET/CT ( Pet/CT)
Naszályi Nagy, Lívia, Bankstahl, Jens P., Wittneben, Alexander, Polyák, András, Zrínyi, Miklós, Görres, Sebastian, Leiter, Ina, Ross, Tobias L., Sajti, Laszlo, Kellermayer, Miklós Sándor Zoltán, Mihály, Judith, Kellermayer, Miklós   +11 more
core   +1 more source

Analytical approaches for assessing immunoconjugates integrity and characterization prior to radiolabeling [PDF]

, 2023
Immunoconjugates, which have highly specific targeting towards certain antigens, are molecules that are built from three parts: an antibody, a therapeutic payload, and a linker between them.
Janevik-Ivanovska, Emilija, Arev, Marija, Apostolova, Paulina   +2 more
core   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Clinically Applicable Cyclotron-Produced Gallium-68 Gives High-Yield Radiolabeling of DOTA-Based Tracers

, 2021
By using solid targets in medical cyclotrons, it is possible to produce large amounts of 68GaCl3. Purification of Ga3+ from metal ion impurities is a critical step, as these metals compete with Ga3+ in the complexation with different chelators, which ...
Mohammad Mahdi Moein, Jonathan Siikanen, Rimma Axelsson, Erik Samén, Thuy A. Tran, Emma Jussing, Stefan Milton, Lovisa Bylund, Moein, MM, Jussing, E,, Samen, E, Axelsson, R,, Bylund, L, Milton, S,, Tran, TA, Siikanen, J,   +15 more
core   +1 more source

Captivated by Kinesin

Cytoskeleton, EarlyView.
ABSTRACT Few proteins have inspired as much curiosity as kinesin. Since its discovery 40 years ago, kinesin has become one of the best understood molecular machines in biology, yet it continues to reveal new questions about how cells organize and move their contents.
Ronald D. Vale
wiley   +1 more source

In vivo Non-invasive Imaging of Radio-Labeled Exosome-Mimetics Derived From Red Blood Cells in Mice

Frontiers in Pharmacology, 2018
Exosomes are natural nano-sized membrane vesicles that have garnered recent interest owing to their potential as drug delivery vehicles. Though exosomes are effective drug carriers, their production and in vivo biodistribution are still not completely ...
Prakash Gangadaran, Prakash Gangadaran, Chae Moon Hong, Chae Moon Hong, Ji Min Oh, Ji Min Oh, Ramya Lakshmi Rajendran, Ramya Lakshmi Rajendran, Senthilkumar Kalimuthu, Senthilkumar Kalimuthu, Seung Hyun Son, Seung Hyun Son, Arunnehru Gopal, Arunnehru Gopal, Liya Zhu, Liya Zhu, Se Hwan Baek, Se Hwan Baek, Shin Young Jeong, Shin Young Jeong, Sang-Woo Lee, Sang-Woo Lee, Jaetae Lee, Jaetae Lee, Byeong-Cheol Ahn, Byeong-Cheol Ahn   +25 more
doaj   +1 more source

In vitro stability studies: ⁶⁸Ga radiolabeling of 100mg SBMP kit with 55μg of SnCl₂.

, 2016
In vitro stability studies: 68Ga radiolabeling of 100mg SBMP kit with 55μg of SnCl2.
Nicolas Lepareur (355037), Olivier Couturier (355042), Franck Lacoeuille (355034), Elise Verger (3221454), Luc Duwez (3221451), Geneviève Meffre (3221457), Claire Bernard (254053), Pierre Drion (399174), François Hindré (355043), Roland Hustinx (2967822)   +9 more
core   +1 more source