Results 61 to 70 of about 33,330 (276)

In Vitro Assessment of ¹⁷⁷Lu-Labeled Trastuzumab-Targeted Mesoporous Carbon@Silica Nanostructure for the Treatment of HER2-Positive Breast Cancer

Pharmaceuticals
This study assessed the effectiveness of a trastuzumab-targeted 177Lu-labeled mesoporous Carbon@Silica nanostructure (DOTA@TRA/MC@Si) for HER2-positive breast cancer treatment, focusing on its uptake, internalization, and efflux in breast cancer cells ...
Ayça Tunçel, Simone Maschauer, Olaf Prante, Fatma Yurt   +3 more
doaj   +1 more source

^99mTc-Labeled Iron Oxide Nanoparticles as Dual-Modality Contrast Agent: A Preliminary Study from Synthesis to Magnetic Resonance and Gamma-Camera Imaging in Mice Models

Nanomaterials, 2022
The combination of two imaging modalities in a single agent has received increasing attention during the last few years, since its synergistic action guarantees both accurate and timely diagnosis.
Maria-Argyro Karageorgou, Aristotelis-Nikolaos Rapsomanikis, Marija Mirković, Sanja Vranješ-Ðurić, Efstathios Stiliaris, Penelope Bouziotis, Dimosthenis Stamopoulos   +6 more
doaj   +1 more source

Additional file 3: of Radiolabeling polymeric micelles for in vivo evaluation: a novel, fast, and facile method

, 2017
Effect of the indium activity on the radiolabeling efficiency.
Adrianus Laan (3762550), Costanza Santini (3762547), Marion de Jong (121558), Antonia Denkova (2484157), Laurence Jennings (3762553), Monique Bernsen (207681)   +5 more
core   +1 more source

A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control

Advanced Science, EarlyView.
Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias, Carmen Domínguez‐Alonso, Ivana Zagorac, Antonio Tapia‐Galisteo, Eva García‐Veros, Laura Rubio‐Pérez, Marina Gómez‐Rosel, Patricia Fuentes, Patricia Hernández‐López, Óscar Aguilar‐Sopeña, Laura Almagro‐Puente, Sonia Martínez‐González, Lucía Cañizares‐Moscato, María Rivas‐Sánchez, Belén Blanco, Ángel Ramírez‐Fernández, Laura Díez‐Alonso, Carmen Blanco‐Aparicio, Javier Arroyo‐Ródenas, Jorge Martínez‐Torrecuadrada, María L. Toribio, Pedro Roda‐Navarro, Anaïs Jiménez‐Reinoso, Luis Álvarez‐Vallina   +23 more
wiley   +1 more source

The Different Strategies for the Radiolabeling of [²¹¹At]-Astatinated Radiopharmaceuticals

Pharmaceutics
Astatine-211 (211At) has emerged as a promising radionuclide for targeted alpha therapy of cancer by virtue of its favorable nuclear properties. However, the limited in vivo stability of 211At-labeled radiopharmaceuticals remains a major challenge.
Jie Gao, Mei Li, Jingjing Yin, Mengya Liu, Hongliang Wang, Jin Du, Jianguo Li   +6 more
doaj   +1 more source

Radiolabeled Liposomes for Nuclear Imaging Probes

Molecules, 2023
Quantitative nuclear imaging techniques are in high demand for various disease diagnostics and cancer theranostics. The non-invasive imaging modality requires radiotracing through the radioactive decay emission of the radionuclide.
Ho Ying Low, Chang-Tong Yang, Bin Xia, Tao He, Winnie Wing Chuen Lam, David Chee Eng Ng   +5 more
doaj   +1 more source

Radiolabeling yields of ¹³¹I-CHIBA-1001 with different conditions.

, 2013
Radiolabeling yields of 131I-CHIBA-1001 with different conditions.
Su Lei Zhang (439553), Lei Yin (300551), Ling Li (38566), Xue Qi Chen (439554), Ping Yan (145638), Lei Kang (90053), Chun Li Zhang (398183), Meng Liu (261774), Rong Fu Wang (398182), Qian Zhao (217607), Chao Ma (207385)   +10 more
core   +1 more source

Dual‐Target Nectin‐4/FAP Heterobivalent Probe 68Ga/177Lu‐FZ‐NF‐1 for Triple‐Negative Breast Cancer: Preclinical Theranostic Evaluation and First‐in‐Human Translation

Advanced Science, EarlyView.
A novel hetero‐bivalent agent, 68Ga/177Lu‐FZ‐NF‐1, concurrently targets Nectin‐4 and FAP in triple‐negative breast cancer. It yields significant preclinical tumor regression and clinically identifies additional metastatic lesions missed by 18F‐FDG PET, demonstrating promising theranostic potential for personalized management.
Ye Li, Li Sun, Xiaoyu Pan, Shuyi Lin, Dongliang Wang, Jianping Zhang, Fengshuang Qiu, Bin Zhu, Lingzhou Zhao, Fengsheng Zhang, Liyan Bai, Bingxin Gu, Xiaoping Xu, Shaoli Song   +13 more
wiley   +1 more source

Development of ¹⁸F/¹¹C-Labeled Pyrrolo-Pyridine/Pyrimidine LRRK2 Selective PET Radioligands

Pharmaceuticals
Background/Objectives: Leucine-rich repeat kinase 2 (LRRK2) is an enzyme implicated in Parkinson’s disease (PD) and a potential therapeutic target. LRRK2 PET radioligands could therefore function as imaging biomarkers for PD and as tools to measure ...
Sangram Nag, Vladimir Stepanov, Akihiro Takano, Ryosuke Arakawa, Marie Svedberg, Nahid Amini, Garrick Paul Smith, Gitte Mikkelsen, Thomas Jensen, Lassina Badolo, Morten Hentzer, Kenneth Vielsted Christensen, Benny Bang-Andersen, Andrea Varrone, Christer Halldin   +14 more
doaj   +1 more source

Radiolabeled Iron Oxide Nanoparticles as Dual Modality Contrast Agents in SPECT/MRI and PET/MRI

Nanomaterials, 2023
During the last decades, the utilization of imaging modalities such as single photon emission computed tomography (SPECT), positron emission tomography (PET), and magnetic resonance imaging (MRI) in every day clinical practice has enabled clinicians to ...
Maria-Argyro Karageorgou, Penelope Bouziotis, Efstathios Stiliaris, Dimosthenis Stamopoulos   +3 more
doaj   +1 more source