Results 61 to 70 of about 32,685 (264)

^99mTc-Labeled Iron Oxide Nanoparticles as Dual-Modality Contrast Agent: A Preliminary Study from Synthesis to Magnetic Resonance and Gamma-Camera Imaging in Mice Models

Nanomaterials, 2022
The combination of two imaging modalities in a single agent has received increasing attention during the last few years, since its synergistic action guarantees both accurate and timely diagnosis.
Maria-Argyro Karageorgou, Aristotelis-Nikolaos Rapsomanikis, Marija Mirković, Sanja Vranješ-Ðurić, Efstathios Stiliaris, Penelope Bouziotis, Dimosthenis Stamopoulos   +6 more
doaj   +1 more source

Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies

Advanced Science, EarlyView.
Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi, Mengsi Lu, Yue Zhang, Anuj Shukla, An‐Li Andrea Ko, Henning J. Jessen   +5 more
wiley   +1 more source

The Different Strategies for the Radiolabeling of [²¹¹At]-Astatinated Radiopharmaceuticals

Pharmaceutics
Astatine-211 (211At) has emerged as a promising radionuclide for targeted alpha therapy of cancer by virtue of its favorable nuclear properties. However, the limited in vivo stability of 211At-labeled radiopharmaceuticals remains a major challenge.
Jie Gao, Mei Li, Jingjing Yin, Mengya Liu, Hongliang Wang, Jin Du, Jianguo Li   +6 more
doaj   +1 more source

Radiolabeled Liposomes for Nuclear Imaging Probes

Molecules, 2023
Quantitative nuclear imaging techniques are in high demand for various disease diagnostics and cancer theranostics. The non-invasive imaging modality requires radiotracing through the radioactive decay emission of the radionuclide.
Ho Ying Low, Chang-Tong Yang, Bin Xia, Tao He, Winnie Wing Chuen Lam, David Chee Eng Ng   +5 more
doaj   +1 more source

Efficient Radiolabeling of Block Copolymer Micelles through Radiometal Salt Precipitation for Theranostic Applications

, 2022
A variety of polymer micelles are designed for the delivery of chemotherapeutic drugs to tumors. Although the promise of these nanocarriers is very high, in the clinic the effectivity is rather limited.
van den Heuvel, E.J. (author), Denkova, A.G., Eelkema, R. (author), Laan, A.C. (author), de Kruijff, R.M., Ramakers, R.M., Eelkema, R., Ramakers, R.M. (author), Denkova, A.G. (author), Beekman, F.J., Beekman, F.J. (author), Liu, H., van den Heuvel, E.J., Liu, H. (author), de Kruijff, R.M. (author), Laan, A.C.   +15 more
core   +2 more sources

ICOS‐ImmunoPET Monitors T Cell Activation After Combination Immune Checkpoint Blockade in a Mouse Model of Melanoma Brain Metastasis

Advanced Science, EarlyView.
ICOS‐immunoPET noninvasively visualizes activated T cells in melanoma brain metastases following combined anti‐PD‐1/anti‐CTLA‐4 therapy. Clinical translation of this imaging approach may improve patient stratification and treatment monitoring and serve as a quantitative imaging endpoint to support immunotherapy development and clinical trials in brain ...
Renesmee C. Kuo, Rohit Verma, Sydney C. Nagy, Mausam Kalita, Samuel Aubert, Josué Ballesteros‐Álvarez, Pedro Machado Almeida, Hannes Vogel, Israt S. Alam, Michael Lim, Michelle L. James   +10 more
wiley   +1 more source

Development of ¹⁸F/¹¹C-Labeled Pyrrolo-Pyridine/Pyrimidine LRRK2 Selective PET Radioligands

Pharmaceuticals
Background/Objectives: Leucine-rich repeat kinase 2 (LRRK2) is an enzyme implicated in Parkinson’s disease (PD) and a potential therapeutic target. LRRK2 PET radioligands could therefore function as imaging biomarkers for PD and as tools to measure ...
Sangram Nag, Vladimir Stepanov, Akihiro Takano, Ryosuke Arakawa, Marie Svedberg, Nahid Amini, Garrick Paul Smith, Gitte Mikkelsen, Thomas Jensen, Lassina Badolo, Morten Hentzer, Kenneth Vielsted Christensen, Benny Bang-Andersen, Andrea Varrone, Christer Halldin   +14 more
doaj   +1 more source

Radiolabeled Iron Oxide Nanoparticles as Dual Modality Contrast Agents in SPECT/MRI and PET/MRI

Nanomaterials, 2023
During the last decades, the utilization of imaging modalities such as single photon emission computed tomography (SPECT), positron emission tomography (PET), and magnetic resonance imaging (MRI) in every day clinical practice has enabled clinicians to ...
Maria-Argyro Karageorgou, Penelope Bouziotis, Efstathios Stiliaris, Dimosthenis Stamopoulos   +3 more
doaj   +1 more source

Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy

Advanced Science, EarlyView.
This modular, site‐specific antibody platform enables customizable conjugates for PET imaging and therapy. Interchangeable payloads – including radiometals, cytotoxics, and fluorophores – support adaptable, multimodal applications with limited off‐target effects. In vivo, the DFO/DOTAGA bischelate immunoconjugate provided clear tumor delineation in PET/
Delphine Vivier, Megane Grah Kple, Julen Ariztia, Marion Leroux, Mathieu Moreau, Michael Claron, Maxime Cheveau, Adam Laouafa, Agnieszka Kownacka, Camille Petitot, John Simonet, Alexandre M. M. Dias, Sophie Poty, Charles Truillet, Bertrand Collin, Alexandra Oudot, Franck Denat   +16 more
wiley   +1 more source

Centrifuge-free cell radiolabeling using acoustophoresis

Scientific Reports
Tracking ex vivo radiolabeled cells using radionuclide imaging such as positron emission tomography is an emerging method for evaluating cell-based therapies.
Stephen S. Adler, Emma Stevenson, Julia Alsveds, Peter L. Choyke, Noriko Sato   +4 more
doaj   +1 more source