Results 61 to 70 of about 38,790 (260)

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Aryl and Alkyl Radiotrifluoromethylation via Metallaphotoredox-Mediated Radical Cross-Coupling. [PDF]

Angew Chem Int Ed Engl
The metallaphotoredox‐mediated radiotrifluoromethylation of arenes and alkanes is described. The operationally simple protocols make use of substrates bearing thianthrenium salts (TT) or N‐hydroxyphthalimide (NHPI) esters and CF218FI. The reaction proceeds through a Ru‐mediated radical formation followed by a Cu‐mediated radical cross‐coupling step and
Veth L, Windhorst AD, Vugts DJ.
europepmc   +3 more sources

Development of ¹⁸F/¹¹C-Labeled Pyrrolo-Pyridine/Pyrimidine LRRK2 Selective PET Radioligands

Pharmaceuticals
Background/Objectives: Leucine-rich repeat kinase 2 (LRRK2) is an enzyme implicated in Parkinson’s disease (PD) and a potential therapeutic target. LRRK2 PET radioligands could therefore function as imaging biomarkers for PD and as tools to measure ...
Sangram Nag, Vladimir Stepanov, Akihiro Takano, Ryosuke Arakawa, Marie Svedberg, Nahid Amini, Garrick Paul Smith, Gitte Mikkelsen, Thomas Jensen, Lassina Badolo, Morten Hentzer, Kenneth Vielsted Christensen, Benny Bang-Andersen, Andrea Varrone, Christer Halldin   +14 more
doaj   +1 more source

Radiolabeled Iron Oxide Nanoparticles as Dual Modality Contrast Agents in SPECT/MRI and PET/MRI

Nanomaterials, 2023
During the last decades, the utilization of imaging modalities such as single photon emission computed tomography (SPECT), positron emission tomography (PET), and magnetic resonance imaging (MRI) in every day clinical practice has enabled clinicians to ...
Maria-Argyro Karageorgou, Penelope Bouziotis, Efstathios Stiliaris, Dimosthenis Stamopoulos   +3 more
doaj   +1 more source

Multiple interfaces between a serine recombinase and an enhancer control site-specific DNA inversion. [PDF]

, 2013
Serine recombinases are often tightly controlled by elaborate, topologically-defined, nucleoprotein complexes. Hin is a member of the DNA invertase subclass of serine recombinases that are regulated by a remote recombinational enhancer element containing
Chang, Yong, Dhar, Gautam, Heiss, John K, Johnson, Reid C, McLean, Meghan M   +4 more
core   +1 more source

Radiolabeled antibody therapy

Seminars in Oncology Nursing, 1987
Summary To summarize, radiolabeled antibodies are used as an experimental therapy to treat certain tumors that have tumor-associated antigens. Preliminary phase I–II studies have shown that radiolabeled antibodies did bring about a remission in some individuals while also avoiding many side effects.
openaire   +2 more sources

CORE: Cholesterol Altered Lipid Nanoparticles for Splenic Expression of mRNA Payloads

Advanced Healthcare Materials, EarlyView.
In this paper researchers introduce CORE LNPs, a new class of lipid nanoparticles engineered to redirect mRNA expression away from the liver and into the spleen, a key immune organ. By combining chemical design with computational tools, they created cholesterol analogs that enable precise spleen‐targeted expression, providing greater applications for ...
Eshan A. Narasipura, Vincent Fung, Rachel VanKeulen‐Miller, Palas B. Tiwade, Owen S. Fenton   +4 more
wiley   +1 more source

The feasibility of radiolabeling for human serum albumin (HSA) adsorption studies [PDF]

, 1978
Human serum albumin (HSA) was labeled in various ways and with different radioactive labels (Technetium-99m and Iodine-125). Characterization with electrophoresis on polyacryl gel and immunoelectrophoresis did not reveal differences between labeled and ...
Feijen, Jan, Klein Elhorst, Jan, Krugers Dagneaux, Paul G.L.C., Scheer, At van der, Smolders, Cees A.   +4 more
core   +3 more sources

Novel radiolabeled antibody conjugates [PDF]

Oncogene, 2007
This article reviews the development of radioimmunoconjugates as a new class of cancer therapeutics. Numerous conjugates involving different antigen targets, antibody forms, radionuclides and methods of radiochemistry have been studied in the half-century since radioactive antibodies were first used in model systems to selectively target radiation to ...
D M, Goldenberg, R M, Sharkey
openaire   +2 more sources

Label‐Free SERS Fingerprinting of Neuroprotein Conformational Dynamics in Human Saliva

Advanced Materials, EarlyView.
Galvanic molecular entrapment (GME) is a label‐free method for detecting and quantifying neuroprotein conformational states. This technique enables direct surface binding and in situ hotspot generation around molecules, effectively overcoming challenges related to target localization and mismatched hotspot geometries.
Muhammad Shalahuddin Al Ja'farawy, Jun‐Yeong Yang, Chaewon Mun, Seunghun Lee, Chul Bum Cho, Yoo Hyun Um, Min‐Young Lee, Sung‐Gyu Park, Dong‐Ho Kim, Seung Ho Yang, Ho Sang Jung   +10 more
wiley   +1 more source