Results 71 to 80 of about 32,685 (264)
Advanced Science, EarlyView.This study shows that a PARP inhibitor combined with anlotinib, administered as bridging therapy, preconditions the tumor microenvironment to enhance the infiltration and antitumor activity of subsequently infused CAR‐T cells across preclinical ovarian cancer models, supporting bridging therapy as a promising strategy to address limited CAR‐T cell ...
Huayi Li +20 more
wiley +1 more source
Pharmaceutics, 2018 (1) Background: Monoclonal antibodies are used in the treatment of multiple conditions including cancer, autoimmune disorders, and infectious diseases.
Kevin J. H. Allen +4 more
doaj +1 more source
A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control
Advanced Science, EarlyView.Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias +23 more
wiley +1 more source
Molecules, 2019 The prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRPR) are identified as important targets on prostate cancer. Receptor-targeting radiolabeled imaging pharmaceuticals with high affinity and specificity are useful in ...
Arijit Ghosh +4 more
doaj +1 more source
Optimizing the radiolabeling of block copolymer micelles using 89Zr
, 2022 Polymeric micelles are increasingly used in chemotherapy. To get a greater understanding of the behaviour of these micelles is important. Nuclear imaging, such as SPECT and PET can provide relevant information about the behaviour of the micelles. However,
Vonk, Stefan (author)
core
Molecules, 2019 In recent years, several catalyst-free site-specific reactions have been investigated for the efficient conjugation of biomolecules, nanomaterials, and living cells.
Sajid Mushtaq +2 more
doaj +1 more source
, 2021 Inert and stable radiolabeling of monoclonal antibodies (mAb), antibody fragments, or antibody mimetics with radiometals is a prerequisite for immuno-PET.
Vugts, Danielle J. +5 more
core +1 more source
Toxins, 2016 The venom of the Eastern coral snake Micrurus fulvius can cause respiratory paralysis in the bitten patient, which is attributable to β-neurotoxins (β-NTx). The aim of this work was to study the biodistribution and lymphatic tracking by molecular imaging
Irene Vergara +7 more
doaj +1 more source
Development of an automated one-step radiolabeling procedure for a PSMA-targeted radiotherapeutic for prostate cancer. [PDF]
Nucl Med BiolBACKGROUND: CTT1403 ((177)Lu-CTT2001), an irreversible phosphoramidate PSMA inhibitor developed by Cancer Targeted Technology, was initially synthesized using a two-step radiolabeling method and has previously been evaluated in first-in-human studies ...
Ocak M +11 more
europepmc +2 more sources
Radiolabeling Strategies of Nanobodies for Imaging Applications
, 2021 Nanobodies are small recombinant antigen-binding fragments derived from camelid heavy-chain only antibodies. Due to their compact structure, pharmacokinetics of nanobodies are favorable compared to full-size antibodies, allowing rapid accumulation to ...
Stefan Kürpig +4 more
core +1 more source