Results 51 to 60 of about 38,790 (260)

VIVID: A qPCR‐Based Platform for Sensitive and Quantitative In Vivo Tracking of Extracellular Vesicles

Advanced Functional Materials, EarlyView.
This study introduces VIVID (Vesicle In Vivo Identification using DNA), a qPCR‐based platform that tracks PCR‐amplifiable DNA tags loaded in the EVs for accurate and quantifiable EV biodistribution in vivo. ABSTRACT Extracellular vesicles (EVs) represent promising carriers for nucleic acid therapeutics, offering advantages over synthetic nanoparticles ...
Oscar Boyadjian, Talin Ebrahimian, Jonathan Miranda O'Connor, Janusz Rak, Stephanie Lehoux, Maryam Tabrizian   +5 more
wiley   +1 more source

Automated synthesis of [89Zr]ZrCl4, [89Zr]ZrDFOSquaramide-bisPh(PSMA) and [89Zr]ZrDFOSquaramide-TATE

EJNMMI Radiopharmacy and Chemistry
Background Automated [89Zr]Zr-radiolabeling processes have the potential to streamline the production of [89Zr]Zr-labelled PET imaging agents. Most radiolabeling protocols use [89Zr][Zr(ox)4]4− as the starting material and oxalate is removed after ...
Asif Noor, Peter D. Roselt, Emily R. McGowan, Stan Poniger, Michael P. Wheatcroft, Paul S. Donnelly   +5 more
doaj   +1 more source

Comparative evaluation of [(99m)tc]tilmanocept for sentinel lymph node mapping in breast cancer patients: results of two phase 3 trials. [PDF]

, 2013
BackgroundSentinel lymph node (SLN) surgery is used worldwide for staging breast cancer patients and helps limit axillary lymph node dissection.
Avisar, Eli, Christman, Lori, Cox, Charles, Deck, Kenneth, Faries, Mark, Frazier, Thomas G, Hall, Nathan C, Han, Linda K, Hoh, Carl K, King, Dennis W, Krontiras, Helen, Limmer, Karl K, Povoski, Stephen P, Schneebaum, Schlomo, Vera, David R, Wallace, Anne M   +15 more
core   +2 more sources

Characterization of an Injectable Poly(vinyl alcohol)‐gelatin Hydrogel for Growth Factor Delivery in an Orthopedic Application

Advanced Healthcare Materials, EarlyView.
This work introduces photo‐crosslinkable tyraminated poly(vinyl alcohol)‐gelatin (PVA‐GT) hydrogels as tunable injectable platforms for tissue engineering and growth factor delivery applications. This schematic illustrates the two developed hydrogel formulations and the experimental workflow used to evaluate their physico‐chemical properties in vitro ...
Alessia Longoni, Gretel S. Major, Sam Arnold, Samuel Tomkins, Eugenia Spessot, Scott Loeffler, Kieran Lau, Richard Tan, Jessica Harte, Roslyn Kemp, Tess Reynolds, Jelena Rnjak‐Kovacina, Gary J. Hooper, Tim B. F. Woodfield, David C. Kieser, Khoon S. Lim   +15 more
wiley   +1 more source

In Vitro Assessment of ¹⁷⁷Lu-Labeled Trastuzumab-Targeted Mesoporous Carbon@Silica Nanostructure for the Treatment of HER2-Positive Breast Cancer

Pharmaceuticals
This study assessed the effectiveness of a trastuzumab-targeted 177Lu-labeled mesoporous Carbon@Silica nanostructure (DOTA@TRA/MC@Si) for HER2-positive breast cancer treatment, focusing on its uptake, internalization, and efflux in breast cancer cells ...
Ayça Tunçel, Simone Maschauer, Olaf Prante, Fatma Yurt   +3 more
doaj   +1 more source

^99mTc-Labeled Iron Oxide Nanoparticles as Dual-Modality Contrast Agent: A Preliminary Study from Synthesis to Magnetic Resonance and Gamma-Camera Imaging in Mice Models

Nanomaterials, 2022
The combination of two imaging modalities in a single agent has received increasing attention during the last few years, since its synergistic action guarantees both accurate and timely diagnosis.
Maria-Argyro Karageorgou, Aristotelis-Nikolaos Rapsomanikis, Marija Mirković, Sanja Vranješ-Ðurić, Efstathios Stiliaris, Penelope Bouziotis, Dimosthenis Stamopoulos   +6 more
doaj   +1 more source

Transcriptome-pathology correlation identifies interplay between TDP-43 and the expression of its kinase CK1E in sporadic ALS. [PDF]

, 2018
Sporadic amyotrophic lateral sclerosis (sALS) is the most common form of ALS, however, the molecular mechanisms underlying cellular damage and motor neuron degeneration remain elusive.
Batra, Ranjan, Baughn, Michael W, Diaz-Garcia, Sandra, Hutt, Kasey, Kohl, Zacharias, Krach, Florian, Libby, Ryan T, Madrigal, Assael A, Pirie, Elaine, Rabin, Stuart J, Ravits, John, Rodriguez, Maria, Saberi, Shahram, Stauffer, Jennifer, Vu, Anthony Q, Wang, Ruth, Wheeler, Emily C, Winner, Beate, Yeo, Gene W   +18 more
core   +1 more source

Nanobody‐Conjugated Theranostic Prodrug Targeting αvβ3 Integrin Enables Precision Cancer Therapy With Real‐Time Imaging

Advanced Healthcare Materials, EarlyView.
The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.
Sanu Karan, Hyunseung Lee, Rema Naskar, Mi Young Cho, Hye Sun Park, Eun Hee Han, Soumyadip Hore, Sun Hee Cho, Truc Ngoc Kim Lam, Taewoong Son, Tae Jung Park, Inkyu Hwang, Jonathan L. Sessler, Kwan Soo Hong   +13 more
wiley   +1 more source

The Different Strategies for the Radiolabeling of [²¹¹At]-Astatinated Radiopharmaceuticals

Pharmaceutics
Astatine-211 (211At) has emerged as a promising radionuclide for targeted alpha therapy of cancer by virtue of its favorable nuclear properties. However, the limited in vivo stability of 211At-labeled radiopharmaceuticals remains a major challenge.
Jie Gao, Mei Li, Jingjing Yin, Mengya Liu, Hongliang Wang, Jin Du, Jianguo Li   +6 more
doaj   +1 more source

Radiolabeled Liposomes for Nuclear Imaging Probes

Molecules, 2023
Quantitative nuclear imaging techniques are in high demand for various disease diagnostics and cancer theranostics. The non-invasive imaging modality requires radiotracing through the radioactive decay emission of the radionuclide.
Ho Ying Low, Chang-Tong Yang, Bin Xia, Tao He, Winnie Wing Chuen Lam, David Chee Eng Ng   +5 more
doaj   +1 more source