Results 41 to 50 of about 32,685 (264)

Radiolabeling Method for Lyophilizate for Dry Powder Inhalation Formulations

, 2022
Human lung deposition data is non-mandatory for drug approval but very useful for the development of orally inhaled drug products. Lung deposition of inhaled drugs can be quantified by radionuclide imaging, for which one of the first considerations is ...
Tomomi Akita, Kahori Miyamoto, Chikamasa Yamashita   +2 more
core   +1 more source

Isotopic Radiolabeling of the Antiretroviral Drug [¹⁸F]Dolutegravir for Pharmacokinetic PET Imaging

Pharmaceuticals, 2022
Deciphering the drug/virus/host interactions at infected cell reservoirs is a key leading to HIV-1 remission for which positron emission tomography (PET) imaging using radiolabeled antiretroviral (ARV) drugs is a powerful asset. Dolutegravir (DTG) is one
Marion Tisseraud, Sébastien Goutal, Thomas Bonasera, Maud Goislard, Delphine Desjardins, Roger Le Grand, Chris M. Parry, Nicolas Tournier, Bertrand Kuhnast, Fabien Caillé   +9 more
doaj   +1 more source

Synthesis and radiolabeling of PSMA-targeted derivatives containing GYK/MVK cleavable linkers [PDF]

, 2023
This file contains all identification, characterisation and radiolabeling data of the compounds described in the main ...
Sophie van den Berg (6884420), van den Berg, Sophie, Seimbille, Yann, Yann Seimbille (3763366), Erik de Blois (3763228), de Jong, Marion, Murce, Erika, de Blois, Erik, Seimbille, Yann; id_orcid, Erika Murce (14668466), Marion de Jong (10321291)   +10 more
core   +2 more sources

Emerging Opportunities for Automated Intelligent Development and Optimization of Radiolabeling Reactions

Journal of Chemical Engineering of Japan
Radiopharmaceuticals form the molecular basis of nuclear imaging and radionuclide therapy. As clinical demand continues to grow, systematic optimization of radiolabeling reactions is increasingly important for efficient and reliable radiopharmaceutical ...
Xin Chen, Jinpei Huang, Xinhui Su, Yiming Mo   +3 more
doaj   +1 more source

Radiolabeling of rCR2.

, 2013
(A) rCR2 was incubated with [99mTc(CO)3(OH2)3]+ at 37°C for 30 minutes at a protein concentration of 1 µg/µL and analysed by instant thin layer chromatography (ITLC). The radiolabeling efficiency was calculated as a ratio of the radiolabeled protein peak
Norhakim Yahya (353612), Gregory E. D. Mullen (67161), David Thakor (353613), Sarah DeFreitas (353608), James M. McDonnell (353610), Reza Razavi (90384), Steven Sacks (353615), Adam Badar (353606), Richard Smith (45265)   +8 more
core   +1 more source

Radiolabeling efficiency.

, 2013
Radiolabeling efficiency of 99mTc-RRL with different conditions. Each time we just changed one condition and fixed others. An orthogonal experimental method was used to find the best radiosynthesis condition.
Ling Li (38566), Lei Yin (300551), Ping Yan (145638), Chun Li Zhang (398183), Rong Fu Wang (398182), Qian Zhao (217607)   +5 more
core   +1 more source

⁶⁸Ga radiolabeling of SBMP.

, 2016
(a) Direct radiolabeling of varied amount of SBMP or native starch with 68GaCl3 eluate. (b) Optimization of 68Ga radiolabeling of varied amount of SBMP with addition of 0.5mL of sodium acetate trihydrate 1M (pH4.1).
Nicolas Lepareur (355037), Olivier Couturier (355042), Franck Lacoeuille (355034), Elise Verger (3221454), Luc Duwez (3221451), Geneviève Meffre (3221457), Claire Bernard (254053), Pierre Drion (399174), François Hindré (355043), Roland Hustinx (2967822)   +9 more
core   +1 more source

Farnesyltransferase Enables Modular Assembly of Dual‐Functional Nanobody Conjugates for in Vivo Imaging of Inflammation

Angewandte Chemie, EarlyView.
A modular farnesyltransferase‐based chemoenzymatic platform enables fast, site‐specific labeling of nanobodies for PET imaging of inflammation. CD11b‐targeted PET agents selectively image myeloid‐driven inflammation, while CD45‐targeted PET agents provide sensitive whole‐body immune mapping.
Sneha Venkatachalapathy, Yoon Ho Lee, Ali Salehi Farid, Heydar Moravej, Sina Djafari Rouhani, Jennifer E. Rowley, Mohammad Rashidian, Mark D. Distefano   +7 more
wiley   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Harnessing the Reactivity of Sulfinate Salts With Cystine: An Umpolung Approach to Residue‐Specific Peptide Modification

Angewandte Chemie, EarlyView.
While cysteine is widely employed as a nucleophilic handle for peptide modification, the electrophilicity of the oxidized form, cystine, is rarely exploited. This study describes a mild, photochemical coupling of sulfinate salts with peptide disulfides.
Joshua M. Hammond, Esteban Suárez‐Picado, Lena von Sydow, Hanna Bruss, Laurent Knerr, Magnus Johansson, Anaïs Noisier, Lara R. Malins   +7 more
wiley   +2 more sources