Results 101 to 110 of about 32,685 (264)

Radiolabeling yields of ¹³¹I-CHIBA-1001 with different conditions.

, 2013
Radiolabeling yields of 131I-CHIBA-1001 with different conditions.
Su Lei Zhang (439553), Lei Yin (300551), Ling Li (38566), Xue Qi Chen (439554), Ping Yan (145638), Lei Kang (90053), Chun Li Zhang (398183), Meng Liu (261774), Rong Fu Wang (398182), Qian Zhao (217607), Chao Ma (207385)   +10 more
core   +1 more source

Bioinorganic Site‐Specific Conjugation of Multi‐Arm Linkers to Create Pharmaceuticals With Targeting and Effector Functions

Journal of the Chinese Chemical Society, EarlyView.
This Account showcases a modular, multi‐arm linker platform that decouples payload loading from antibody conjugation. By leveraging a computationally designed ACPGHA zinc‐binding motif, we demonstrate the construction of homogeneous antibody‐drug conjugates and theranostic antibody‐radionuclide conjugates with high payload loading. The multi‐arm linker
Cédric Grauffel, Tse Wen Chang, Carmay Lim   +2 more
wiley   +1 more source

Radiolabeled antibody therapy

Seminars in Oncology Nursing, 1987
Summary To summarize, radiolabeled antibodies are used as an experimental therapy to treat certain tumors that have tumor-associated antigens. Preliminary phase I–II studies have shown that radiolabeled antibodies did bring about a remission in some individuals while also avoiding many side effects.
openaire   +2 more sources

Comparison of the magnetic, radiolabeling, hyperthermic and biodistribution properties of hybrid nanoparticles bearing CoFe2O4and Fe3O4metal cores

, 2014
Metal oxide nanoparticles, hybridized with various polymeric chemicals, represent a novel and breakthrough application in drug delivery, hyperthermia treatment and imaging techniques.
COMES FRANCHINI, MAURO, C. Sangregorio, G. Loudos, G. Baldi, C. Innocenti, D. Psimadas, LOCATELLI, ERICA, C. Ravagli   +7 more
core   +1 more source

Optimization of the Cell‐Based Assay Methodology to Study Degradation of Acetylcholine Receptors (Antigenic Modulation) by Antibodies From Myasthenia Gravis Patients

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Degradation of cell‐surface acetylcholine receptors (AChRs) by antigenic modulation is a key pathogenic mechanism of myasthenia gravis (MG) autoantibodies, yet standard assays primarily detect antibody binding rather than functional effects.
Peng Du, Marina Mané‐Damas, Fien M. Verhamme, Mahan Moshir, Peter Ulrichts, Barbie Machiels, Mario Losen, Pilar Martinez‐Martinez   +7 more
wiley   +1 more source

Challenges in Optimizing a Prostate Carcinoma Binding Peptide, Identified through the Phage Display Technology

Molecules, 2011
The transfer of peptides identified through the phage display technology to clinical applications is difficult. Major drawbacks are the metabolic degradation and label instability.
Jürgen Debus, Uwe Haberkorn, Walter Mier, Annabell Marr, Shoaib Rana, Frederic Zoller, Annette Altmann, Vasileios Askoxylakis, Annette Markert, Sabine Zitzmann-Kolbe   +9 more
doaj   +1 more source

Investigation of bacterial adherence to a non-precious alloy with radiolabeling method

, 2006
The objective of this study was to investigate the bacterial adherence to a non-precious alloy with radiolabeling method. S. mutans, E. coliand C. albicanswere labeled with Tc-99m by using stannous chloride and their radiolabeling yields were calculated.
F. Yurt Lambrecht, Lambrecht, FY, Destan, UI, M. Sonugelen, Sonugelen, M, Ozturk, B, B. Öztürk, U. ?yiyap?c? Destan   +7 more
core   +1 more source

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

A novel cost-effective approach for the efficient radiolabeling of dendritic macromolecules with a β-emitting radiotracer

, 2013
We describe herein a novel method for the radiolabeling of macromolecules containing primary amine groups. The method utilises radiolabeled acetic acid and exploits commonly used coupling chemistry for conjugation to primary amines in aqueous conditions.
Aljayyoussi, Ghaith, Gumbleton, Mark
core   +1 more source

Sodium Ions Affect GPR17 Conformational States and Functionality

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo, Simona Daniele, Davide Bianchi, Lara Russo, Stefano Capaldi, Maria Letizia Trincavelli, Ivano Eberini   +6 more
wiley   +1 more source