Results 101 to 110 of about 33,330 (276)

New amino bisphosphonate compound for skeletal imaging: Comparison study with methylenediphosphonic acid (MDP) and (1-hydroxyethane-1,1-diyl) diphosphonic acid (HEDP)

Nukleonika, 2016
A novel bisphosphonate derivative (1-aminoethane-1,1-diyl)diphosphonic acid (AEDP) has been prepared and successfully labeled with 99mTc at high labeling yields.
Assaad Thaer
doaj   +1 more source

[¹⁸F]Fluoroalkyl azides for rapid radiolabeling and (Re)investigation of their potential towards in vivo click chemistry

, 2017
[18F]Fluoroalkyl azides were developed as efficient click agents for rapid radiolabeling, and (re)investigated towards application in pretargeted PET imaging.
Skrinjar, Philipp, Thomas Filip, Martin Wilkovitsch, Denk, Christoph, Severin Mairinger, Wanek, Thomas, Dennis Svatunek, Johannes Fröhlich, Claudia Kuntner, Thomas Wanek, Wilkovitsch, Martin, Christoph Denk, Svatunek, Dennis, Filip, Thomas, Kuntner, Claudia, Mairinger, Severin, Fröhlich, Johannes, Hannes Mikula, Mikula, Hannes; orcid:, Philipp Skrinjar   +19 more
core   +1 more source

Effectiveness and safety of efgartigimod in patients with anti‐NMDAR or anti‐LGI1 encephalitis and its 18F‐DPA714 PET imaging evaluation: A multicenter, single‐arm, prospective, observational real‐world study

Neuroprotection, EarlyView.
Abstract Background Efgartigimod disrupts the recycling of pathogenic IgG autoantibodies and may represent a candidate therapy for autoimmune encephalitis. This real‐world study evaluated the clinical efficacy, safety, and impact of efgartigimod on brain inflammation.
Huanyu Meng, Siqi Tu, Yifan Zhou, Ruinan Shen, Xiaoyu Chen, Zhaozhao Cheng, Limei Wang, Yan Wu, Jie Lu, Shengjun Wang, Yan Xu, Wanhui Lin, Sheng Chen   +12 more
wiley   +1 more source

Radiolabeled antibody therapy

Seminars in Oncology Nursing, 1987
Summary To summarize, radiolabeled antibodies are used as an experimental therapy to treat certain tumors that have tumor-associated antigens. Preliminary phase I–II studies have shown that radiolabeled antibodies did bring about a remission in some individuals while also avoiding many side effects.
openaire   +2 more sources

Radiolabeling of BSA with [¹⁸F]SFB synthesized using chip 2 (data are the mean ± S.D., n = 4).

, 2016
Radiolabeling of BSA with [18F]SFB synthesized using chip 2 (data are the mean ± S.D., n = 4).
Ren Iwata (812734), Hiroyuki Kimura (261126), Yuji Kuge (458337), Kenji Arimitsu (180751), Masahiro Ono (106488), Hiroaki Nakanishi (2727712), Eiichi Ozeki (1765183), Hidekazu Saiki (3154818), Kenji Tomatsu (3154821), Hidekazu Kawashima (2259781), Hideo Saji (458369)   +10 more
core   +1 more source

Noninvasive Diagnosis of Splenosis Using Tc‐99m Heat‐Denatured Red Blood Cell Scintigraphy

American Journal of Hematology, EarlyView.
Natacha Dewarrat, Katharina Auf der Springe, Francesco Grandoni, Rami Hajri, Mathilde Gavillet   +4 more
wiley   +1 more source

Patient iPSC‐derived astrocytes reveal impaired homeostasis and reactive‐like features in propionic acidemia

The Journal of Pathology, EarlyView.
Abstract Propionic acidemia (PA) is a neurometabolic disorder caused by propionyl‐CoA carboxylase deficiency with frequent neurological involvement, yet cell‐type‐specific mechanisms remain poorly defined. We established human induced pluripotent stem cell (iPSC)‐derived astrocytes (iAs) from patients harboring PCCA or PCCB mutations and investigated ...
Irene González‐Garnacho, Mar Álvarez, Francisco Zafra, Pilar Rodríguez‐Pombo, Lourdes R Desviat, Eva Richard   +5 more
wiley   +1 more source

Challenges in Optimizing a Prostate Carcinoma Binding Peptide, Identified through the Phage Display Technology

Molecules, 2011
The transfer of peptides identified through the phage display technology to clinical applications is difficult. Major drawbacks are the metabolic degradation and label instability.
Jürgen Debus, Uwe Haberkorn, Walter Mier, Annabell Marr, Shoaib Rana, Frederic Zoller, Annette Altmann, Vasileios Askoxylakis, Annette Markert, Sabine Zitzmann-Kolbe   +9 more
doaj   +1 more source

[¹⁸F]ODIBO: a prosthetic group for bioorthogonal radiolabeling of macromolecules via strain-promoted alkyne–azide cycloaddition

, 2018
[18F]oxadibenzocyclooctyne ([18F]ODIBO) allows for efficient biorthogonal radiolabeling of macromolecules at low concentrations and room temperature via SPAAC.
Christopher D. McNitt, Alexey P. Kostikov, Mehdi Boudjemeline, Thomas A. Singleton, Vladimir V. Popik   +4 more
core   +1 more source

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source