Results 121 to 130 of about 32,685 (264)

Anchoring Group-Mediated Radiolabeling of Inorganic NanoparticlesA Universal Method for Constructing Nuclear Medicine Imaging Nanoprobes

Nuclear medicine imaging has aroused great interest in the design and synthesis of versatile radioactive nanoprobes, while most of the methods developed for radiolabeling nanoprobes are difficult to satisfy the criteria of clinical translation, including
Yun Gao (381225), Yi Zhou (2723), Jianfeng Zeng (1650133), Zhiyuan Zhong (1403683), Jianxian Ge (9547909), Qing Li (84975), Can Chen (675404), Lei Chen (54296), Baoxing Huang (405394), Ling Wen (1556440), Mingyuan Gao (1406650), Dandan Zhou (1573039)   +11 more
core   +1 more source

Targeted Photo‐Induced Elimination of Tumor‐Associated Macrophages Suppresses Cancer Progression in a Murine Model

Cancer Science, EarlyView.
This study demonstrates the selective depletion of tumor‐associated macrophages (TAMs) by targeting CSF1R through near‐infrared photoimmunotherapy (NIR‐PIT). Using a combination of anti‐CSF1R Fab‐IR700 conjugates and localized light irradiation, we achieved tumor suppression and durable antitumor immunity without systemic toxicity.
Kohei Nakajima, Tomomi Uchiyama, Kazuki Funayama, Yuto Goto, Akari Mukaimine, Naoya Ieda, Mikako Ogawa   +6 more
wiley   +1 more source

Ploidy‐dependent modulation of DNA replication kinetics in Xenopus

The FEBS Journal, EarlyView.
Using an interspecies replication system with Xenopus frog species of different ploidy levels, we investigated how DNA replication adapts to polyploidization. While replication was slower in tetraploid than in diploid nuclei, dodecaploid nuclei unexpectedly replicated faster than tetraploid nuclei. Our findings show that increasing genome size does not
Hemalatha Narassimprakash, Olivier Haccard, Zhen Li, Nicolas Pollet, Kathrin Marheineke   +4 more
wiley   +1 more source

Caste‐Associated Social Context Modulates Behavioural Interactions With Insecticide‐Exposed Individuals in Nasutitermes corniger (Termitidae: Nasutitermitinae)

Journal of Applied Entomology, EarlyView.
ABSTRACT Termites are eusocial insects that maintain cohesion and exchange information through frequent physical interactions among nestmates. This social organisation underlies the principle of horizontal insecticide transfer, which is widely exploited as a termite control strategy.
Sara Yuri Medeiros Watanabe, Lazaro Quintino de Lira Filho, Derick Lira, Guilherme de Souza Batista Pereira, Thiago Henrique Cavalcanti de Mendonça, Paulo Fellipe Cristaldo   +5 more
wiley   +1 more source

Auxin response and PIN‐mediated transport in chlorophyte algae

Journal of Integrative Plant Biology, EarlyView.
Like multicellular plants, green algae respond to auxin and move it across their cells. However, their PIN‐like proteins do not act like plant auxin exporters, suggesting that basic auxin transport evolved early and specialized directional transport appeared later in plant evolution.
Adrijana Smoljan, Sarah Koutnik‐Abele, Dmitrii Vladimirtsev, Petr Klíma, Anita Bírošíková, Yuzhou Zhang, Jack Merrin, Maximilian Schuster, Katarina Kurtović, Ulrich Z. Hammes, Jan Petrášek, Jiří Friml   +11 more
wiley   +1 more source

Development of Anti-Yersinia pestis Human Antibodies with Features Required for Diagnostic and Therapeutic Applications

ImmunoTargets and Therapy, 2020
Antonietta M Lillo,1 Nileena Velappan,1 Julia M Kelliher,1 Austin J Watts,1 Samuel P Merriman,1 Grace Vuyisich,2 Laura M Lilley,2 Kent E Coombs,1 Tara Mastren,2 Munehiro Teshima,1 Benjamin W Stein,2 Gregory L Wagner,2 Srinivas Iyer,1 Andrew RM Bradbury,3
Lillo AM, Velappan N, Kelliher JM, Watts AJ, Merriman SP, Vuyisich G, Lilley LM, Coombs KE, Mastren T, Teshima M, Stein BW, Wagner GL, Iyer S, Bradbury ARM, Harris JF, Dichosa AE, Kozimor SA   +16 more
doaj  

Development of a Thin Layer Chromatography method to determine the radiolabeling stability of PCL-PEO micelles radiolabeled with ¹⁷⁷Lu

, 2021
Polymeric micelles have a promising future in the treatment of cancer patients, and particularly as carriers in chemotherapy. The effectiveness of the micelles can be determined when their fate in vivo is known. Radiolabeling the micelles with diagnostic
Kerstjens, Willem (author)
core  

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Stable and high-yielding intrinsic ⁵⁹Fe-radiolabeling of the intravenous iron preparations Monofer and Cosmofer:Intrinsic 59Fe-radiolabeling of Monofer and Cosmofer

, 2016
Commercial iron supplements Monofer((R)) and Cosmofer((R)) were intrinsically radiolabeled with Fe-59 for the purpose of tracing iron absorption in vivo. Optimized procedures aimed at introducing Fe-59 into the macromolecular construct in a form that was
Jensen, Andreas Tue Ingemann, Andreasen, Hans B., Severin, Gregory, Gregory W. Severin, Palle H. Rasmussen, Hans B. Andreasen, Rasmussen, Palle, Andreas I. Jensen   +7 more
core   +1 more source

A Single‐Nucleotide Substitution Generates a de Novo Promoter That Activates a Latent Metabolic Bypass in Escherichia coli

Molecular Microbiology, EarlyView.
A chromosomal mutation allows bypass of deletion of the Escherichia coli fabH gene. The bypass results from creation of a new promoter that drives increased madA transcription, resulting in increased synthesis of acetyl‐acyl carrier protein by decarboxylation of malonyl‐acyl carrier protein.
Qiaoqiao Guo, Qi Zou, Jilong Qin, Makrina Totsika, Yaoqin Hong, John E. Cronan   +5 more
wiley   +1 more source