Results 131 to 140 of about 32,685 (264)

The Role of torS and torT Transcription in Driving a Bet‐Hedging Strategy for Trimethylamine N‐Oxide Reductase Expression in Escherichia coli

open access: yesMolecular Microbiology, EarlyView.
Low basal activity of divergent promoters driving transcription of the trimethylamine N‐oxide (TMAO) sensor TorT and kinase TorS is integral to an O2‐regulated bet‐hedging strategy for continued E. coli growth upon the onset of anaerobiosis. This, along with repression by IscR, promotes noise in the TorS to TorT ratio, which is critical for adaptation ...
Erin L. Mettert   +4 more
wiley   +1 more source

Understanding extracellular vesicle biology, isolation, and characterization: The theory of EV‐erything

open access: yesPeriodontology 2000, EarlyView.
Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad   +6 more
wiley   +1 more source

Periodontitis and metabolic dysfunction‐associated steatotic liver disease

open access: yesPeriodontology 2000, EarlyView.
Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon   +6 more
wiley   +1 more source

Comparative Study of NOTA-Derived Chelators: Synthesis, Al18F/177Lu Radiolabeling and Computational Analysis

open access: yes
The development of hybrid bifunctional chelators (BFCs) capable of efficiently coordinating both diagnostic and therapeutic radionuclides remains a major challenge in theranostic radiopharmaceutical design. Herein, two novel hybrid NOTA-derived chelators,
Xavier Assfeld   +4 more
core   +1 more source

MCT1‐mediated bidirectional propionate transport across human placental syncytiotrophoblast layer: insights from a trophoblast stem cell‐derived barrier model

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Propionate in the fetal circulation is thought to originate from fermentation of dietary fibre by the maternal gut microbiota. However, the mechanism of transplacental transport has remained unclear. Here, we measured propionate permeability using a placental barrier model generated by differentiating human placental trophoblast ...
Toshiaki Tsuchitani   +8 more
wiley   +1 more source

89Zr-Df-CD45 radiolabeling of hPBSC.

open access: yes, 2013
hPBSC were labeled with 0, 20, 40, 80, or 160 µCi/mL of 89Zr-Df-CD45. No significant changes in cell viability were observed with increasing concentrations. However, a greater degree of radiolabeling was observed with 80 and 160 µCi/mL of 89Zr-Df-CD45. A
C. Chang I. Lee (414865)   +3 more
core   +1 more source

Multiple‐TE Based Blood–Brain‐Barrier Water Exchange Time Measurement Using a TE‐Resolved 3D TSE Stack‐Of‐Spirals Readout

open access: yesMagnetic Resonance in Medicine, Volume 96, Issue 4, Page 1629-1644, October 2026.
ABSTRACT Purpose To develop a slice‐wise blurring‐free and densely sampled TE‐resolved multiple‐TE (mTE) ASL sequence (TASL) for measuring blood–brain barrier (BBB) water exchange time. Methods A 3D TSE spiral‐readout pCASL sequence was modified to enable TE‐resolved acquisition.
Bo Li   +11 more
wiley   +1 more source

Development and evaluation of 177Lu-imatinib: radiolabeling and cell culture studies

open access: yes
Targeted radiopharmaceuticals offer promising approaches for cancer diagnosis and therapy. This study developed freeze-dried kit formulations of 177Lu-Imatinib (IMT) and evaluated their potential efficacy through in vitro studies.
Güler, Günnur   +5 more
core   +1 more source

Strategies for radiolabeling of commercial TiO2 nanopowder as a tool for sensitive nanoparticle detection in complex matrices

open access: yes, 2015
Detection and quantification of engineered nanoparticles (NPs) in complex environmental or biological media is a major challenge since NP concentrations are generally expected to be low compared to elemental background levels.
GIBSON Peter   +5 more
core   +1 more source

Hyperpolarized MRI in Oncology—A Review of Clinical Studies and Evaluation of Preclinical Liver Studies

open access: yesNMR in Biomedicine, Volume 39, Issue 10, October 2026.
Hyperpolarized MRI is a promising clinical imaging modality in oncology, offering at least nine imaging contrasts obtainable with hyperpolarized [1‐13C]pyruvate as the injected agent, depending on the tissue and condition under investigation. Preclinical studies suggest that hyperpolarized MRI is warranted for detecting hepatocellular carcinoma within ...
Naama Lev‐Cohain   +2 more
wiley   +1 more source

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