Results 151 to 160 of about 33,330 (276)

Functional Characterization of the P‐Type ATPases ATP13A3 and ATP13A4 as Plasma Membrane Polyamine Transporters

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
ATP13A3 and ATP13A4 mediate the plasma membrane uptake of the polyamines, putrescine and spermidine, in an ATP‐dependent manner. ATP13A3 is broadly expressed across human tissues, whereas ATP13A4 is expressed at relatively high levels in the brain and lung.
Haruka Morimoto, Tomoya Yasujima, Mione Yamasaki, Takahiro Yamashiro, Hiroaki Yuasa   +4 more
wiley   +1 more source

ICOS‐ImmunoPET Monitors T Cell Activation After Combination Immune Checkpoint Blockade in a Mouse Model of Melanoma Brain Metastasis

Advanced Science, Volume 13, Issue 56, 9 October 2026.
ICOS‐immunoPET noninvasively visualizes activated T cells in melanoma brain metastases following combined anti‐PD‐1/anti‐CTLA‐4 therapy. Clinical translation of this imaging approach may improve patient stratification and treatment monitoring and serve as a quantitative imaging endpoint to support immunotherapy development and clinical trials in brain ...
Renesmee C. Kuo, Rohit Verma, Sydney C. Nagy, Mausam Kalita, Samuel Aubert, Josué Ballesteros‐Álvarez, Pedro Machado Almeida, Hannes Vogel, Israt S. Alam, Michael Lim, Michelle L. James   +10 more
wiley   +1 more source

Comparative Study of NOTA-Derived Chelators: Synthesis, Al¹⁸F/¹⁷⁷Lu Radiolabeling and Computational Analysis. [PDF]

Int J Mol Sci
Dhimen A, Assfeld X, Karcher G, Collet C, Acherar S.   +4 more
europepmc   +1 more source

In Situ Self‐Assembled Molecular Fortifying Agent for Enhanced Retention and Therapeutic Efficacy of Radiopharmaceuticals

Aggregate, Volume 7, Issue 10, October 2026.
A molecular‐fortifying agent strategy based on in situ self‐assembly is developed to prolong tumor retention of radioligands. After tumor‐targeting, FAP‐α cleavage triggers nanofiber formation, presenting azide anchors for bioorthogonal capture of pre‐accumulated radioligands.
Daojia Liu, Xiaoqin Luo, Xiaojuan Wang, Xing Liu, Fanglei Zhang, Pan Wang, Jibin Song, Junqiang Chen   +7 more
wiley   +1 more source

Cognitive impairment in Parkinson disease correlates with loss of cholinergic axon projections to cortex in an autopsy study

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION People with Parkinson's disease (PD) frequently develop dementia. We investigated the relationship between cognitive impairment and the loss of cholinergic axon projections from the nucleus basalis of Meynert to neocortical regions in PD.
Rebecca Miller, Jennifer O'Shea, Laura M. Rosok, Sydney Lim, Erin E. Franklin, Richard J. Perrin, Helen Hwang, Dhruva Dhavale, Joel Perlmutter, Meghan C. Campbell, Paul Kotzbauer   +10 more
wiley   +1 more source

H3K9me3 inhibition reverses Alzheimer's progression by restoring synaptic and immune proteostasis across the brain–retina axis

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Epigenetic dysregulation is increasingly linked to aging and neurodegeneration, yet its contribution to retinal and brain pathology in Alzheimer's disease (AD) remains unclear. METHODS We quantified the repressive epigenetic mark histone H3 lysine 9 trimethylation (H3K9me3) in post mortem retinas and brains from donors spanning ...
Dieu‐Trang Fuchs, Jean‐Philippe Vit, Altan Rentsendorj, Yosef Koronyo, Julia Sheyn, Bhakta Prasad Gaire, Saba Shahin, Haoshen Shi, Oksana Chepurna, Miyah R. Davis, Jered W. Wilson, Stuart L. Graham, Vivek K. Gupta, Lon S. Schneider, Michael T. Kleinman, Tao Sun, Margaret Fahnestock, David A. Horne, Mehdi Mirzaei, Keith L. Black, Maya Koronyo‐Hamaoui   +20 more
wiley   +1 more source

Development and characterization of [^99mTc]Tc-lornoxicam as a potential COX-assisted radiopharmaceutical for inflammation imaging. [PDF]

RSC Adv
Batool A, Jabar T, Fatima SM, Waji-Ul-Hassan SM, Rubab N, Naseeb Ahmad HK, Ramadan MF, Aldawood N, Alkahtani TO, Alshihri AA, Lodhi NA, Raza Naqvi SA.   +11 more
europepmc   +1 more source

Advances in Peptide‐Targeted Fluorescent Probes for the Diagnosis and Therapy of Brain Disorders

ChemistryEurope, Volume 4, Issue 10, October 2026.
This review summarizes peptide‐based fluorescent probes for major brain diseases, such as Alzheimer's and Parkinson's. It highlights their precise biomarker targeting and high sensitivity for imaging pathological processes in vivo. These probes also show great potential for enabling theranostic applications, thereby offering real‐time monitoring and ...
Shuangjing Yang, Yuting Wang, Yongkang Yue, Fangjun Huo, Caixia Yin   +4 more
wiley   +1 more source

Radiolabeled exosomes for theranostics: Personalized tailored therapy through imaging. [PDF]

World J Radiol
Phadikar SD, Hyder A, Rajendran RL, Krishnan A, Hong CM, Gangadaran P, Ahn BC.   +6 more
europepmc   +1 more source

Most Early‐Born Subplate Neurons Persist as Layer 6b Neurons in the Adult Mouse Neocortex

Journal of Comparative Neurology, Volume 534, Issue 10, October 2026.
Comprehensive EdU birthdating and 3D volumetric analyses revealed that most early‐born subplate neurons (SpNs) persist into adulthood as layer 6b (L6b) neurons in the mouse neocortex. Green circles indicate SpNs/L6b neurons, and magenta labeling indicates EdU‐labeled early‐born neurons.
Yusuke Sugita, Keiko Moriya‐Ito, Carina Hanashima, Chiaki Ohtaka‐Maruyama   +3 more
wiley   +1 more source