Results 141 to 150 of about 38,790 (260)

Modular Assembly of Dynamic Polymer Networks From Heteroaffinity Cross‐Links to Multivalent Proteins

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
This study develops a method to modularly assemble oligomeric binding proteins, like streptavidin, using heterobifunctional cross‐linkers that have both a strong‐ and a weak‐affinity binding moiety. These dynamic cross‐linkers enable the assembly of polymer networks with unique meta‐stable nonequilibrium topologies, and that exhibit chemically tunable ...
Tianyue Dai, Yuntao Qiu, Katherine M. Leon Hernandez, Wesley Chan, Katrina Mejia, Natalia Nemeria, Colin D. Kinz‐Thompson   +6 more
wiley   +2 more sources

Quantitative Pharmacokinetics Reveal Impact of Lipid Composition on Microbubble and Nanoprogeny Shell Fate

Advanced Science
Microbubble‐enabled focused ultrasound (MB‐FUS) has revolutionized nano and molecular drug delivery capabilities. Yet, the absence of longitudinal, systematic, quantitative studies of microbubble shell pharmacokinetics hinders progress within the MB‐FUS ...
Maneesha A. Rajora, Alexander Dhaliwal, Mark Zheng, Victor Choi, Marta Overchuk, Jenny W. H. Lou, Carly Pellow, David Goertz, Juan Chen, Gang Zheng   +9 more
doaj   +1 more source

Genome‐Scale Engineering Importing Property of Escherichia coli for Improving Production of 3‐Hydroxypropionic Acid

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
We developed a systematic workflow to identify genes responsible for 3‐HP import by combining a genomic library with a fluorescent biosensor. Deleting the identified import‐related genes reduced product re‐uptake, successfully increasing 3‐HP titers by 21% and providing a new strategy for optimising microbial production platforms.
Seungjin Kim, Junyeong Sung, Ga Yeon Lim, Gyoo Yeol Jung, Hyun Gyu Lim   +4 more
wiley   +1 more source

Positron Emission Tomography Imaging of Bacterial Infections With an Enterobactin Analog to Monitor Treatment Efficacy With a Catechol Antibiotic

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
Synopsis. The [68Ga]GaIII‐TREN‐CAM radiochelate selectively accumulates in Gram‐negative sites of infection and noninvasively monitors treatment response a siderophore antibiotic. ABSTRACT Positron emission tomography (PET) is an emerging tool under clinical investigation for the detection of bacterial infections.
M. Andrey Joaqui‐Joaqui, Phuong Nguyen Tran, Axia Marlin, Fiona Armstrong‐Pavlik, Minhua Cao, Valérie C. Pierre, Eszter Boros   +6 more
wiley   +2 more sources

Vesicular glutamate transporter VGLUT2 expression emerges in substantia nigra dopamine neurons in mouse models of parkinsonism in the absence of neurodegeneration

British Journal of Pharmacology, Volume 183, Issue 9, Page 2123-2138, May 2026.
Abstract Background and Purpose Subsets of midbrain dopamine (DA) neurons express the vesicular glutamate transporter VGLUT2 and can release the excitatory neurotransmitter glutamate. VGLUT2+ DA neurons of the substantia nigra pars compacta (SNc) were shown to be more resistant to neurodegeneration in animal models of Parkinson's disease (PD ...
Sivakumar Srinivasan, Christian Pifl, Thomas Steinkellner   +2 more
wiley   +1 more source

Safety of [68Ga]Ga‐FAPI‐46 PET/CT including hemodynamic measurements and patient‐reported outcomes in cancer patients

Clinical Physiology and Functional Imaging, Volume 46, Issue 3, May 2026.
Abstract Introduction Aim Fibroblast activation protein inhibitor (FAPI) has demonstrated promising oncological diagnostic performance. Although no adverse events (AEs) have been previously reported, a formal safety evaluation of FAPI PET/CT is lacking.
Morten Bentestuen, Camilla Sylvest, Svend B. Jensen, Lara R. Soro, Aage Knudsen, Morten Ladekarl, Ole Thorlacius‐Ussing, Wolfgang P. Fendler, Helle D. Zacho   +8 more
wiley   +1 more source

Human α2‐Macroglobulin: Architecture, Mechanisms, and Functional Implications

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Visual representation of human α2‐macroglobulin in its native and induced conformations. General functions associated with the native form (green), the induced form (white), and both conformations (light red) are indicated. ABSTRACT α2‐Macroglobulin (α2M) is a large glycoprotein and one of the most abundant proteins found in the plasma of vertebrates ...
Pietro de Carvalho Andrade, Tales Alexandre Costa‐Silva, Gisele Monteiro   +2 more
wiley   +1 more source

Preparation, molecular docking, and biological evaluation of radioiodinated cefaclor for inflammation detection. [PDF]

BMC Pharmacol Toxicol
Hussien H, El Refaye MS, Aglan H, Challan SB, Khater SI.   +4 more
europepmc   +1 more source

Clinical nuclear medicine applications of zirconium-89 immuno-PET: a comprehensive review from a radiopharmaceutical perspective. [PDF]

EJNMMI Radiopharm Chem
Dubois J, Deshayes E, Kucharczak F, Cadet MM, Zhou J, Paunet T, Fersing C.   +6 more
europepmc   +1 more source

Development of an automated one-step radiolabeling procedure for a PSMA-targeted radiotherapeutic for prostate cancer. [PDF]

Nucl Med Biol
Ocak M, Sikligar K, Pun M, Ho KV, Ling X, Carroll VN, Simón J, Fulton MD, Bomba HN, Berkman CE, Langton-Webster BC, Anderson CJ.   +11 more
europepmc   +1 more source