Results 111 to 120 of about 88,244 (379)

Combining dose and injection volume for good performance of a specific radiopharmaceutical for sentinel node detection [PDF]

, 2012
Introduction: the aim of this work was to quantify the effects of injection volume at different technetium-99m specific radiotracer doses on its lymphatic movement in animal model.Procedures: Effects of injection volume (50, 100 mu l) at different doses (
Fernandez Nunez, Eutimio Gustavo, Oliveira Filho, Renato Santos de, Oliveira, Érica Aparecida de, Silva, Natanael Gomes da   +3 more
core   +1 more source

Development of Radiolabeled Membrane Type-1 Matrix Metalloproteinase Activatable Cell Penetrating Peptide Imaging Probes

Molecules, 2015
Membrane type-1 matrix metalloproteinase (MT1-MMP or MMP-14) plays an important role in adverse cardiac remodelling. Here, we aimed to develop radiolabeled activatable cell penetrating peptides (ACPP) sensitive to MT1-MMP for the detection of elevated ...
Sander M. J. van Duijnhoven, Marc S. Robillard, Klaas Nicolay, Holger Grüll   +3 more
doaj   +1 more source

Reducing the Burden of Interaction Studies in Cancer Patients Using a Stable Isotopically Labeled Microtracer: A Proof‐of‐Concept Study with Alectinib

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional drug‐food interaction studies of oral anticancer agents have a high patient burden. A patient‐friendly alternative approach to studying food effects could be the use of stable isotopically labeled microtracers. A prospective, single‐center, open‐label, crossover, food effect study with the microtracer 2H6‐alectinib was conducted in patients
Ma Ida Mohmaed Ali, Lisa T. van der Heijden, Matthijs Tibben, Hilde Rosing, Raween Kalicharan, Gerrina Ruiter, Jos H. Beijnen, Hinke Huisman‐Siebinga, Alwin D. R. Huitema, Neeltje Steeghs   +9 more
wiley   +1 more source

Preparation of 99mtc-tricine-edda-hynic-folate, a Potential Radiopharmaceutical for Radiodiagnosis of Folate Receptors Over Expressed Cancer [PDF]

, 2013
PREPARATION OF 99mTc-TRICINE-EDDA-HYNIC-FOLATE, A POTENTIAL RADIOPHARMACEUTICAL FOR RADIODIAGNOSIS OF FOLATE RECEPTORS OVER EXPRESSED CANCER. Folate receptors (FRs) have been reported to be over expressed on various types of cancers.
Humani, T. S. (Titis), Ramli, M. (Martalena), Ritawidya, R. (Rien), Rustendi, C. T. (Cecep), Widjaksana, W. (Widyastuti)   +4 more
core  

¹⁷⁷Lu-Labeled Iron Oxide Nanoparticles Functionalized with Doxorubicin and Bevacizumab as Nanobrachytherapy Agents against Breast Cancer

Molecules
The use of conventional methods for the treatment of cancer, such as chemotherapy or radiotherapy, and approaches such as brachytherapy in conjunction with the unique properties of nanoparticles could enable the development of novel theranostic agents ...
Evangelia-Alexandra Salvanou, Argiris Kolokithas-Ntoukas, Danai Prokopiou, Maria Theodosiou, Eleni Efthimiadou, Przemysław Koźmiński, Stavros Xanthopoulos, Konstantinos Avgoustakis, Penelope Bouziotis   +8 more
doaj   +1 more source

Optimized Solid Phase-Assisted Synthesis of Dendrons Applicable as Scaffolds for Radiolabeled Bioactive Multivalent Compounds Intended for Molecular Imaging

Molecules, 2014
Dendritic structures, being highly homogeneous and symmetric, represent ideal scaffolds for the multimerization of bioactive molecules and thus enable the synthesis of compounds of high valency which are e.g., applicable in radiolabeled form as ...
Gabriel Fischer, Björn Wängler, Carmen Wängler   +2 more
doaj   +1 more source

Manual vs. automated 68 Ga-radiolabeling - a comparison of optimized processes.

Journal of labelled compounds & radiopharmaceuticals, 2019
A critical factor for clinical practice is the production of 68 Ga-radiopharmaceuticals manufactured manually or through an automated procedure. 68 Ga-radiopharmaceuticals are often prepared manually, although this method can lead to an increased ...
Michael Meisenheimer, S. Kürpig, M. Essler, E. Eppard   +3 more
semanticscholar   +1 more source

Guided Sample Pooling in Human Mass Balance Studies: A Recommended Strategic Decision Framework

Clinical Pharmacology &Therapeutics, EarlyView.
Radiolabeled human mass balance studies are crucial for identifying circulating metabolites and understanding drug absorption, excretion, and clearance pathways. Metabolite profiling involves quantifying all drug‐related entities, including parent drug and metabolites in plasma and excreta, using extended liquid chromatography methods coupled with ...
Filip Cuyckens, Wenying Li, Adam M. Auclair, Kenneth C. Cassidy, Cathy Cantalloube, Gary Collins, Alexander D. James, Chris Gibson, Ulrike Glaenzel, Felix Huth, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Pietro Brunetti, Hanno Schieferstein, David Wagner, Gregory S. Walker, Shuai Wang, Qin Yue, Jason Boer, Cyrus Khojasteh   +21 more
wiley   +1 more source

Radiosynthesis, in vitro and preliminary in vivo evaluation of the novel glutamine derived PET tracers [18F]fluorophenylglutamine and [18F]fluorobiphenylglutamine

, 2020
INTRODUCTION: Glucose has been deemed the driving force of tumor growth for decades. However, research has shown that several tumors metabolically shift towards glutaminolysis.
Baguet, Tristan, Beyzavi, M. Hassan, De Lombaerde, Stef, De Vos, Filip, Descamps, Benedicte, Donche, Sam, Goethals, Ingeborg, Hu, Jiyun, Lambe, Patricia, Pauwelyn, Glenn, Piron, Sarah, Vanhove, Christian, Verhoeven, Jeroen   +12 more
core   +1 more source

Preclinical efficacy of hK2 targeted [177Lu]hu11B6 for prostate cancer theranostics [PDF]

, 2019
Androgen ablating drugs increase life expectancy in men with metastatic prostate cancer, but resistance inevitably develops. In a majority of these recurrent tumors, the androgen axis is reactivated in the form of increased androgen receptor (AR ...
Beattie, Bradley J., Beattie, Kai A., Elgqvist, Jörgen, Eriksson, Sophie E., Larsson, Erik, Strand, Sven-Erik, Thorek, Daniel L. J., Timmermand, Oskar Vilhelmsson, Tran, Thuy A., Ulmert, David, Örbom, Anders   +10 more
core   +2 more sources