Results 111 to 120 of about 87,481 (331)

Investigating an organ-targeting platform based on hydroxyapatite nanoparticles using a novel in situ method of radioactive 125Iodine labeling [PDF]

, 2014
In this study, we have investigated the synthesis of nanoparticles of hydroxyapatite (HAp) and hydroxyapatite coated with chitosan (HAp/Ch) and the chitosan-poly-d,l-lactide-co-glycolide polymer blend (HAp/Ch-PLGA) as an organ-targeting system.
Ignjatović, Nenad, Janković, Drina, Mitić, Žarko, Uskoković, Dragan, Vranješ Đurić, Sanja   +4 more
core   +3 more sources

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Preparation of 99mtc-tricine-edda-hynic-folate, a Potential Radiopharmaceutical for Radiodiagnosis of Folate Receptors Over Expressed Cancer [PDF]

, 2013
PREPARATION OF 99mTc-TRICINE-EDDA-HYNIC-FOLATE, A POTENTIAL RADIOPHARMACEUTICAL FOR RADIODIAGNOSIS OF FOLATE RECEPTORS OVER EXPRESSED CANCER. Folate receptors (FRs) have been reported to be over expressed on various types of cancers.
Humani, T. S. (Titis), Ramli, M. (Martalena), Ritawidya, R. (Rien), Rustendi, C. T. (Cecep), Widjaksana, W. (Widyastuti)   +4 more
core  

Combining dose and injection volume for good performance of a specific radiopharmaceutical for sentinel node detection [PDF]

, 2012
Introduction: the aim of this work was to quantify the effects of injection volume at different technetium-99m specific radiotracer doses on its lymphatic movement in animal model.Procedures: Effects of injection volume (50, 100 mu l) at different doses (
Fernandez Nunez, Eutimio Gustavo, Oliveira Filho, Renato Santos de, Oliveira, Érica Aparecida de, Silva, Natanael Gomes da   +3 more
core   +1 more source

Manual vs. automated 68 Ga-radiolabeling - a comparison of optimized processes.

Journal of labelled compounds & radiopharmaceuticals, 2019
A critical factor for clinical practice is the production of 68 Ga-radiopharmaceuticals manufactured manually or through an automated procedure. 68 Ga-radiopharmaceuticals are often prepared manually, although this method can lead to an increased ...
Michael Meisenheimer, S. Kürpig, M. Essler, E. Eppard   +3 more
semanticscholar   +1 more source

AI‐Driven Microphysiological Systems for Advancing Nanoparticle Therapeutics

Advanced Intelligent Systems, EarlyView.
This review outlines recent advances in integrating artificial intelligence with microphysiological systems for nanoparticle evaluation. It highlights data‐driven optimization, image‐based prediction, and AI‐enabled analysis frameworks that advance translational research and support the development of personalized nanomedicine. Nanoparticles (NPs) play
Yedam Lee, Jaehong Min, Sujin Kim, Jihoon Ko   +3 more
wiley   +1 more source

A Chelate-Free Nano-Platform for Incorporation of Diagnostic and Therapeutic Isotopes

International Journal of Nanomedicine, 2020
Yaser H Gholami, 1– 4 Lee Josephson, 3 Eman A Akam, 5 Peter Caravan, 5 Moses Q Wilks, 3 Xiang-Zuo Pan, 3, 6 Richard Maschmeyer, 1 Aleksandra Kolnick, 3, 7 Georges El Fakhri, 3 Marc D Normandin, 3 Zdenka Kuncic, 1, 4, 8 Hushan Yuan 3 1The ...
Gholami YH, Josephson L, Akam EA, Caravan P, Wilks MQ, Pan XZ, Maschmeyer R, Kolnick A, El Fakhri G, Normandin MD, Kuncic Z, Yuan H   +11 more
doaj  

Challenges in Optimizing a Prostate Carcinoma Binding Peptide, Identified through the Phage Display Technology

Molecules, 2011
The transfer of peptides identified through the phage display technology to clinical applications is difficult. Major drawbacks are the metabolic degradation and label instability.
Jürgen Debus, Uwe Haberkorn, Walter Mier, Annabell Marr, Shoaib Rana, Frederic Zoller, Annette Altmann, Vasileios Askoxylakis, Annette Markert, Sabine Zitzmann-Kolbe   +9 more
doaj   +1 more source

Synthesis and bioevaluation of 125 I-labeled gold nanorods [PDF]

, 2011
A novel technique is described for monitoring the in vivo behavior of gold nanorods (GNRs) using _-imaging. GNRs were radiolabeled using [ 125 I] sodium iodide in a simple and fast manner with high yield and without disturbing their optical properties ...
Agarwal, Ashish, Kotov, Nicholas A., Rajian, Justin R, Shao, Xia, Wang, Xueding   +4 more
core   +1 more source

[O-methyl-¹¹C]N-(4-(4-(3-Chloro-2-methoxyphenyl)-piperazin-1-yl)butyl)-1H-indole-2-carboxamide ([¹¹C]BAK4-51) Is an Efflux Transporter Substrate and Ineffective for PET Imaging of Brain D₃ Receptors in Rodents and Monkey

Molecules, 2018
Selective high-affinity antagonists for the dopamine D3 receptor (D3R) are sought for treating substance use disorders. Positron emission tomography (PET) with an effective D3R radioligand could be a useful tool for the development of such therapeutics ...
Jeih-San Liow, Cheryl L. Morse, Shuiyu Lu, Michael Frankland, George L. Tye, Sami S. Zoghbi, Robert L. Gladding, Anver B. Shaik, Robert B. Innis, Amy H. Newman, Victor W. Pike   +10 more
doaj   +1 more source