Results 161 to 170 of about 87,481 (331)

Radiolabeled Bombesin Analogs [PDF]

, 2021
Rosalba Mansi, Berthold A. Nock, Simone U. Dalm, Martijn B. Busstra, Wytske M. van Weerden, Θεοδοσία Μάινα   +5 more
openalex   +1 more source

A minimal physiologically‐based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti‐LAG‐3 monoclonal antibody

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 460-473, March 2025.
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Robin Michelet, Klas Petersson, Marc C. Huisman, C. Willemien Menke‐van der Houven van Oordt, Iris H. C. Miedema, Andrea Thiele, Ghazal Montaseri, Alejandro Pérez‐Pitarch, David Busse   +8 more
wiley   +1 more source

Tc-99m Radiolabeled Peptide p5 + 14 is an Effective Probe for SPECT Imaging of Systemic Amyloidosis

, 2015
Stephen J. Kennel, Alan Stuckey, Helen P. McWilliams‐Koeppen, Tina Richey, Jonathan S. Wall   +4 more
openalex   +1 more source

Development of a Radiolabeled Folate-Mediated Drug Delivery System for Effective Delivery of Docetaxel [PDF]

, 2023
Oğuz Çetin, Burcu Güngör, Çiğdem İçhedef, Yasemın Parlak, Elvan Sayıt Bilgin, Funda Üstün, Gülay Durmuş Altun, Yücel Başpınar, Serap Teksöz   +8 more
openalex   +1 more source

Application of Physiologically‐Based Pharmacokinetic Modeling to Support Drug Labeling: Prediction of CYP3A4‐Mediated Pirtobrutinib‐Drug Interactions

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Pirtobrutinib is a reversible Bruton tyrosine kinase (BTK) inhibitor. In vitro, pirtobrutinib is metabolized by cytochrome P450 (CYP) 3A4 and uridine 5′‐diphosphoglucuronosyl transferases (UGTs) and causes reversible and time‐dependent inhibition and induction of CYP3A4.
Dan‐Dan Tian, Stephen D. Hall, Sonya C. Chapman, Maria M. Posada   +3 more
wiley   +1 more source

Tunable and noncytotoxic PET/SPECT-MRI multimodality imaging probes using colloidally stable ligand-free superparamagnetic iron oxide nanoparticles

International Journal of Nanomedicine, 2017
TH Nguyen Pham,1 Nigel A Lengkeek,2 Ivan Greguric,2 Byung J Kim,1 Paul A Pellegrini,2 Stephanie A Bickley,3 Marcel R Tanudji,3 Stephen K Jones,3 Brian S Hawkett,1 Binh TT Pham1 1Key Centre for Polymers and Colloids, School of Chemistry, University of ...
Pham THN, Lengkeek NA, Greguric I, Kim BJ, Pellegrini PA, Bickley SA, Tanudji MR, Jones SK, Hawkett BS, Pham BTT   +9 more
doaj  

In vitro/in vivo assessment of novel 99mTc-bombesin conjugates in human cancer tissue [abstract] [PDF]

, 2007
only availableReceptor-specific, radiolabeled peptides are becoming increasingly popular as targeting vectors for the development of new diagnostic radiopharmaceuticals.
Heinzke, Laura, Hoffman, Timothy Joseph, 1958-, Lane, Stephanie R., 1982-, Prasanphanich, Adam, Retzloff, Lauren Brooke, 1980-, Rold, Tammy L., Sieckman, Gary, Smith, Charles J. (Charles Jeffrey), 1969-   +7 more
core  

Impact of Obesity and MASH on Zonal Hepatocellular Statin Exposure: Pharmacodynamic Insights From a Permeability‐Limited Multicompartment Liver Model

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
Obesity, MASH and Statins: Insights from a PBPK/PD Zonal Liver Model. ABSTRACT Statins are frequently prescribed for hyperlipidemia, a common comorbidity in patients with obesity and/or metabolic dysfunction‐associated steatohepatitis (MASH). However, limited knowledge exists on how MASH may alter statin disposition within hepatocytes where the statin ...
William A. Murphy, Noora Sjöstedt, Mailys De Sousa Mendes, Mattie Hartauer, Kim L. R. Brouwer, Sibylle Neuhoff   +5 more
wiley   +1 more source

Synthesis, Radiolabeling, and Biological Evaluation of (R)- and (S)-2-Amino-5-[¹⁸F]fluoro-2-methylpentanoic Acid ((R)-, (S)-[¹⁸F]FAMPe) as Potential Positron Emission Tomography Tracers for Brain Tumors

, 2015
Ahlem Bouhlel, Dong Zhou, Aixiao Li, Liya Yuan, Keith M. Rich, Jonathan McConathy   +5 more
openalex   +1 more source

Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (PBPK) models have been utilized extensively for initial dosing regimen and sampling ...
James W. T. Yates, Michael Zientek, Kunal S. Taskar, Wen Lin, Tycho Heimbach, Stefan Willmann, Jessica Rehmel, Neil Parrott, Michael Hanley, Justine Badee, Yuan Chen, Susan Cole, Loeckie De Zwart, Sebastian Haertter, Rongrong Jiang, Masakatsu Kotsuma, Guiqing Liang, Yu‐Wei Lin, Jing Liu, Ying Ou, Juliane Rascher, Naveed A. Shaik, Jan Wahlstrom, Xiaofeng Wang, Guangqing Xiao, Ka Lai Yee, S. Y. Amy Cheung   +26 more
wiley   +1 more source