Results 11 to 20 of about 87,481 (331)

Radiolabeling of functional oligonucleotides for molecular imaging

Frontiers in Bioengineering and Biotechnology, 2022
Molecular imaging has greatly advanced basic biology and translational medicine through visualization and quantification of molecular events in a cellular context and living organisms.
Dunfang Liu, Dunfang Liu, Qian Xia, Qian Xia, Ding Ding, Weihong Tan, Weihong Tan, Weihong Tan   +7 more
doaj   +2 more sources

Comparative Study of Two Oxidizing Agents, Chloramine T and Iodo-Gen^®, for the Radiolabeling of β-CIT with Iodine-131: Relevance for Parkinson’s Disease

Pharmaceuticals, 2019
Parkinson’s disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, leading to alteration of the integrity of dopaminergic transporters (DATs).
Ana Claudia R. Durante, Danielle V. Sobral, Ana Claudia C. Miranda, Érika V. de Almeida, Leonardo L. Fuscaldi, Marycel R. F. F. de Barboza, Luciana Malavolta   +6 more
doaj   +2 more sources

Metabolic radiolabeling and in vivo PET imaging of cytotoxic T lymphocytes to guide combination adoptive cell transfer cancer therapy [PDF]

Journal of Nanobiotechnology, 2021
Background Adoptive T cell transfer-based immunotherapy yields unsatisfactory results in the treatment of solid tumors, partially owing to limited tumor infiltration and the immunosuppressive microenvironment in solid tumors.
Dehua Lu, Yanpu Wang, Ting Zhang, Feng Wang, Kui Li, Shixin Zhou, Hua Zhu, Zhi Yang, Zhaofei Liu   +8 more
openalex   +2 more sources

Sc(III) Complexes of Pyclen Derivative Ligands as Probes for Hypoxia: Synthesis, Chemical Characterization, ⁴⁴ Sc‐Radiolabeling, and Preclinical Assessment [PDF]

Chemistry – A European Journal, EarlyView.
Hypoxia‐sensitive nitroimidazole‐functionalized pyclen derivatives were successfully synthesized and radiolabeled with 44Sc(III), affording stable and inert scandium complexes. Remarkable Sc(III)‐binding capabilities of the PC2A‐mono(amide) platform enabled excellent radiolabeling performance, with ≥92–99% yields and ≥99% radiochemical purity. MicroPET
Tibor Csupász, Bayar Dahman, Tamás Gyula Gál, Istvan Kapus, Zita Képes, Dániel Szücs, György Trencsényi, Imre Tóth, Anikó Fekete, Gyula Tircso, Tibor Csupász, Bayar Dahman, Tamás Gyula Gál, Istvan Kapus, Zita Képes, Dániel Szücs, György Trencsényi, Imre Tóth, Anikó Fekete, Gyula Tircso   +19 more
openalex   +2 more sources

Optimized production, purification, and radiolabeling of the 203Pb/212Pb theranostic pair for nuclear medicine

Scientific Reports, 2023
TRIUMF is one of the only laboratories in the world able to produce both lead-203 (^203Pb, t_1/2 = 51.9 h) and ^212Pb (t_1/2 = 10.6 h) onsite via its 13 and 500 MeV cyclotrons, respectively.
Brooke L McNeil, Simona Mastroianni, S. McNeil, S. Zeisler, J. Kumlin, Sogol Borjian, Anthony W. McDonagh, M. Cross, P. Schaffer, C. Ramogida   +9 more
semanticscholar   +1 more source

Direct Cell Radiolabeling for in Vivo Cell Tracking with PET and SPECT Imaging

Chemical Reviews, 2022
The arrival of cell-based therapies is a revolution in medicine. However, its safe clinical application in a rational manner depends on reliable, clinically applicable methods for determining the fate and trafficking of therapeutic cells in vivo using ...
P. Gawne, F. Man, P. Blower, Rafael T. M. de Rosales   +3 more
semanticscholar   +1 more source

The role of radiolabeling in BNCT tracers for enhanced dosimetry and treatment planning

Theranostics, 2023
Positron emission tomography (PET) and single photon emission computed tomography (SPECT) are potent technologies for non-invasive imaging of pharmacological and biochemical processes in both preclinical and advanced clinical research settings.
Sajid Mushtaq, Park Ji Ae, Jung Young Kim, K. Lee, Kwang Il Kim   +4 more
semanticscholar   +1 more source

PET Imaging of Small Extracellular Vesicles via [89Zr]Zr(oxinate)4 Direct Radiolabeling

Bioconjugate chemistry, 2022
Exosomes or small extracellular vesicles (sEVs) are increasingly gaining attention for their potential as drug delivery systems and biomarkers of disease.
Azalea A Khan, F. Man, F. Faruqu, Jana Kim, F. Al-Salemee, A. Carrascal-Miniño, A. Volpe, Revadee Liam-or, Paul Simpson, G. Fruhwirth, K. Al‐Jamal, Rafael T. M. de Rosales   +11 more
semanticscholar   +1 more source

State of the Art in Radiolabeling of Antibodies with Common and Uncommon Radiometals for Preclinical and Clinical Immuno-PET

Bioconjugate chemistry, 2021
Inert and stable radiolabeling of monoclonal antibodies (mAb), antibody fragments, or antibody mimetics with radiometals is a prerequisite for immuno-PET.
Marion Chomet, G. V. van Dongen, D. Vugts   +2 more
semanticscholar   +1 more source

Towards Targeted Alpha Therapy with Actinium-225: Chelators for Mild Condition Radiolabeling and Targeting PSMA—A Proof of Concept Study

Cancers, 2021
Simple Summary In nuclear medicine, therapeutic methods are used increasingly, in which tumors are destroyed by ionizing radiation that cannot or can only be treated insufficiently by other methods like surgery or chemotherapy.
Falco Reissig, David Bauer, K. Zarschler, Z. Nový, K. Bendová, Marie-Charlotte Ludik, K. Kopka, H. Pietzsch, M. Petřík, C. Mamat   +9 more
semanticscholar   +1 more source