Results 21 to 30 of about 87,481 (331)

Cell radiolabeling with acoustophoresis cell washing

Scientific Reports, 2022
Labeling immune cells with zirconium-89 (89Zr)-oxine has become a viable method to track cells in vivo by PET in various pre-clinical animal models and in clinical applications.
S. Adler, Emmanuel C. Nyong, Raisa A. Glabman, P. Choyke, N. Sato   +4 more
semanticscholar   +1 more source

Clinically Applicable Cyclotron-Produced Gallium-68 Gives High-Yield Radiolabeling of DOTA-Based Tracers

Biomolecules, 2021
By using solid targets in medical cyclotrons, it is possible to produce large amounts of 68GaCl3. Purification of Ga3+ from metal ion impurities is a critical step, as these metals compete with Ga3+ in the complexation with different chelators, which ...
E. Jussing, S. Milton, Erik Samén, M. Moein, L. Bylund, R. Axelsson, J. Siikanen, Thuy A. Tran   +7 more
semanticscholar   +1 more source

Nanobody-Based Theranostic Agents for HER2-Positive Breast Cancer: Radiolabeling Strategies

International Journal of Molecular Sciences, 2021
The overexpression of human epidermal growth factor 2 (HER2) in breast cancer (BC) has been associated with a more aggressive tumor subtype, poorer prognosis and shorter overall survival.
I. Hrynchak, Liliana Santos, A. Falcão, Célia M Gomes, A. Abrunhosa   +4 more
semanticscholar   +1 more source

Advances in Development of Radiometal Labeled Amino Acid-Based Compounds for Cancer Imaging and Diagnostics

Pharmaceuticals, 2021
Radiolabeled biomolecules targeted at tumor-specific enzymes, receptors, and transporters in cancer cells represent an intensively investigated and promising class of molecular tools for the cancer diagnosis and therapy.
Mária Bodnár Mikulová, Peter Mikuš
doaj   +1 more source

Radiolabeling of Human Serum Albumin With Terbium-161 Using Mild Conditions and Evaluation of in vivo Stability

Frontiers in Medicine, 2021
Targeted radionuclide therapy (TRNT) is a promising approach for cancer therapy. Terbium has four medically interesting isotopes (149Tb, 152Tb, 155Tb and 161Tb) which span the entire radiopharmaceutical space (TRNT, PET and SPECT imaging). Since the same
Irwin Cassells, S. Ahenkorah, A. Burgoyne, M. Van de Voorde, C. Deroose, T. Cardinaels, G. Bormans, M. Ooms, F. Cleeren   +8 more
semanticscholar   +1 more source

Blood-brain barrier transport kinetics of NOTA-modified proteins : the somatropin case [PDF]

, 2020
BACKGROUND: Chemical modifications such as PEG, polyamine and radiolabeling on proteins can alter their pharmacokinetic behaviour and their blood-brain barrier (BBB) transport characteristics. NOTA, i.e. 1,4,7-triazacyclononane-1,4,7-triacetic acid, is a
Bracke, Nathalie, De Spiegeleer, Bart, Janssens, Yorick, Maes, Alex, Sathekge, Mike, Tack, Liesa, Van De Wiele, Christophe, Wynendaele, Evelien   +7 more
core   +1 more source

Standardization of the [68Ga]Ga-PSMA-11 Radiolabeling Protocol in an Automatic Synthesis Module: Assessments for PET Imaging of Prostate Cancer

Pharmaceuticals, 2021
Prostate-specific membrane antigen (PSMA) is a glycoprotein present in the prostate, that is overexpressed in prostate cancer (PCa). Recently, PSMA-directed radiopharmaceuticals have been developed, allowing the pinpointing of tumors with the Positron ...
L. L. Fuscaldi, D. V. Sobral, A. C. R. Durante, Fernanda F Mendonça, A. Miranda, M. L. da Cunha, Luciana Malavolta, J. Mejia, M. F. de Barboza   +8 more
semanticscholar   +1 more source

Preliminary Evaluation of Iron Oxide Nanoparticles Radiolabeled with ⁶⁸Ga and ¹⁷⁷Lu as Potential Theranostic Agents

Nanomaterials, 2022
Theranostic radioisotope pairs such as Gallium-68 (68Ga) for Positron Emission Tomography (PET) and Lutetium-177 (177Lu) for radioisotopic therapy, in conjunction with nanoparticles (NPs), are an emerging field in the treatment of cancer.
Evangelia-Alexandra Salvanou, Argiris Kolokithas-Ntoukas, Christos Liolios, Stavros Xanthopoulos, Maria Paravatou-Petsotas, Charalampos Tsoukalas, Konstantinos Avgoustakis, Penelope Bouziotis   +7 more
doaj   +1 more source

Radiolabeling of Gold Nanocages for Potential Applications in Tracking, Diagnosis, and Image‐Guided Therapy

Advanced Healthcare Materials, 2021
Gold nanocages (AuNCs) have emerged as a novel class of multifunctional nanomaterials with an array of applications in nanomedicine, including drug delivery, controlled release, as well as disease diagnosis and treatment.
Jichuan Qiu, Yongjian Liu, Younan Xia
semanticscholar   +1 more source

Evaluation of a PACAP Peptide Analogue Labeled with (68)Ga Using Two Different Chelating Agents. [PDF]

, 2016
OBJECTIVE: The authors have conjugated chelating agents (DOTA and NODAGA) with a peptide (pituitary adenylate cyclase-activating peptide [PACAP] analogue) that has a high affinity for VPAC1 receptors expressed on cancer cells.
Chen, Chang-Po, Kumar, Pardeep, Mehta, Neil, Paudyal, Bishnuhari, Thakur, Mathew L., Tripathi, Sushil Kumar, Wickstrom, Eric   +6 more
core   +2 more sources