Results 1 to 10 of about 22,357 (216)
Frontiers in Oncology, 2019 Targeted radiopharmaceutical conjugates intended for therapeutic use often are made of three key components, a decaying radionuclide, a chemical chelator/linker, and a targeted molecular entity.
Charles A. Kunos +2 more
exaly +3 more sources
Radiopharmaceutical Therapy [PDF]
Health Physics, 2019 Abstract Radiopharmaceutical therapy involves the use of radionuclides that are either conjugated to tumor-targeting agents (e.g., nanoscale constructs, antibodies, peptides, and small molecules) or that concentrate in tumors through natural physiological mechanisms that occur predominantly in neoplastic cells.
Robert F Hobbs
exaly +3 more sources
Analysis of Radiopharmaceuticals [PDF]
Journal of AOAC INTERNATIONAL, 1971 Abstract Some of the activities of chemists engaged in evaluating and selecting analytical methodology for examination of radiopharmaceuticals and the criteria for assessment of their quality are described. Significant problems, as they relate to a regulatory analysis program, and tentative solutions to these problems are discussed ...
Max Jaffee, Leonard A. Ford
openalex +3 more sources
Radiolabeled Silicon-Rhodamines as Bimodal PET/SPECT-NIR Imaging Agents
Pharmaceuticals, 2021 Radiolabeled fluorescent dyes are decisive for bimodal imaging as well as highly in demand for nuclear- and optical imaging. Silicon-rhodamines (SiRs) show unique near-infrared (NIR) optical properties, large quantum yields and extinction coefficients as
Thines Kanagasundaram +6 more
doaj +1 more source
EJNMMI Radiopharmacy and Chemistry, 2023 Background [18F]fluoromisonidazole ([18F]FMISO, 1H-1-(3-[18F]fluoro-2-hydroxypropyl)-2-nitroimidazole) is a commonly used radiotracer for imaging hypoxic conditions in cells.
Torsten Kniess +5 more
doaj +1 more source
CRISPR/Cas9 Mediated Knockout of Cyclooxygenase-2 Gene Inhibits Invasiveness in A2058 Melanoma Cells
Cells, 2022 The inducible isoenzyme cyclooxygenase-2 (COX-2) is an important hub in cellular signaling, which contributes to tumor progression by modulating and enhancing a pro-inflammatory tumor microenvironment, tumor growth, apoptosis resistance, angiogenesis and
Cathleen Haase-Kohn +4 more
doaj +1 more source
Therapy with Radiopharmaceuticals [PDF]
Acta Oncologica, 2002 In an investigation by the Swedish Cancer Society, an expert group described the present status, critical issues and future aspects and potentials for each of nine major areas of radiation therapy research. The present report deals with therapy with radiopharmaceuticals.
Jörgen, Carlsson +4 more
openaire +3 more sources
The Radiobiology of Radiopharmaceuticals
Seminars in Radiation Oncology, 2021 Radiopharmaceutical therapy or targeted radionuclide therapy (TRT) is a well-established class of cancer therapeutics that includes a growing number of FDA-approved drugs and a promising pipeline of experimental therapeutics. Radiobiology is fundamental to a mechanistic understanding of the therapeutic capacity of these agents and their potential ...
Andrew Z. Wang +2 more
openaire +3 more sources
Molecules, 2022 COX-2 can be considered as a clinically relevant molecular target for adjuvant, in particular radiosensitizing treatments. In this regard, using selective COX-2 inhibitors, e.g., in combination with radiotherapy or endoradiotherapy, represents an ...
Florian Brandt +7 more
doaj +1 more source
EJNMMI Radiopharmacy and Chemistry, 2022 Background Positron emission tomography (PET) is a powerful tool in medical imaging, especially in combination with the PET radionuclide fluorine-18 that possesses optimal characteristics.
Carsten Sven Kramer +3 more
doaj +1 more source