Results 91 to 100 of about 22,462 (308)

Advances in Anticancer Radiopharmaceuticals

Clinical Oncology, 2013
This review highlights recent progress in the development of anticancer radiopharmaceuticals. Molecularly targeted radiotherapy refers to the selective delivery of radionuclides that emit charged particles, such as α particles, β or Auger electrons, to cancer cells via a targeting vector.
Katherine A. Vallis, Mark R. Jackson, Nadia Falzone, Nadia Falzone   +3 more
openaire   +3 more sources

Evaluation of resazurin phenoxazine dye as a highly sensitive cell viability potency assay for natural killer cell‐derived extracellular vesicle‐based cancer biotherapeutics

Journal of Extracellular Biology
Natural killer cell‐derived extracellular vesicles (NK‐EVs) are candidate biotherapeutics against various cancers. However, standardised potency assays are necessary for a reliable assessment of NK‐EVs' cytotoxicity.
Frederic St‐Denis‐Bissonnette, Shirley Qiu, Sarah E. Cummings, Melanie Kirkby, Yohannes Haile, Sarah Wassmer, Gauri Muradia, Jelica Mehic, Andrew Stalker, Amit Shrestha, Michele Ardolino, Seung‐Hwan Lee, Dylan Burger, Lisheng Wang, Jessie R. Lavoie   +14 more
doaj   +1 more source

Radiopharmaceutical transport in solid tumors via a 3-dimensional image-based spatiotemporal model

npj Systems Biology and Applications
Lutetium-177 prostate-specific membrane antigen (177Lu-PSMA)-targeted radiopharmaceutical therapy is a clinically approved treatment for patients with metastatic castration-resistant prostate cancer (mCRPC).
Anahita Piranfar, Farshad Moradi Kashkooli, Wenbo Zhan, Ajay Bhandari, Babak Saboury, Arman Rahmim, M. Soltani   +6 more
doaj   +1 more source

Expert Consensus on the Diagnosis and Treatment of Malignant Pericardial Mesothelioma

Med Research, EarlyView.
ABSTRACT Primary malignant pericardial mesothelioma (PMPM), a rare pericardium‐derived malignancy, urgently requires standardized diagnostic and therapeutic protocols. This consensus, established by the Chinese Alliance of Research for Mesothelioma (ChARM) through the integration of evidence‐based research and multicenter clinical expertise, addresses ...
Qing Ji, Chunwei Xu, Qian Wang, Wenxian Wang, Zhenying Guo, Ziming Li, Zhengbo Song, Aijun Liu, Jinpu Yu, Wenzhao Zhong, Zhijie Wang, Wenfeng Fang, Yongchang Zhang, Jingjing Liu, Shirong Zhang, Xiuyu Cai, Anwen Liu, Ping Zhan, Hongbing Liu, Tangfeng Lv, Liyun Miao, Lingfeng Min, Gen Lin, Long Huang, Chen Yu, Jingping Yuan, Zhansheng Jiang, Feng Wang, Xingxiang Pu, Chuangzhou Rao, Dongqing Lv, Yinghua Ji, Xianbin Liang, Zongyang Yu, Xiaoyan Li, Chuanhao Tang, Chengzhi Zhou, Junping Zhang, Xuelei Ma, Hui Guo, Qian Chu, Rui Meng, Jingxun Wu, Huaiqing Xiao, Jin Zhou, Zhengfei Zhu, Hongmei Zhang, Yingshi Piao, Xiaofeng Chen, Xuewen Liu, Enyong Dai, Yu Yao, Jian Zhang, Weiwei Pan, Fei Pang, Fan Wu, Zhiying Shao, Ling Xu, Liping Wang, Jianfei Tu, Yu Zhang, Xinqing Lin, Jing Cai, Jian Feng, Jisheng Li, Xiaodong Jiao, Kainan Li, Huijing Feng, Lin Wang, Yingying Du, Binbin Song, Xuefei Shi, Wenfeng Li, Xiaomin Niu, Jianhui Huang, Yina Wang, Yue Feng, Yinbin Zhang, Pingli Sun, Hong Wang, Dongmei Yuan, Yanwen Yao, Dong Wang, Mingxiang Ye, Zhaofeng Wang, Yue Hao, Jianan Jin, Zhen Wang, Bing Wan, Donglai Lv, Shengjie Yang, Lin Shi, Bihui Li, Zhang Zhang, Zhongwu Li, Zhefeng Liu, Nong Yang, Lin Wu, Miao Li, Xiaobing Li, Guansong Wang, Jiandong Wang, Yong Fang, Yuan Li, Yiping Zhang, Xixu Zhu, Yi Shen, Ke Wang, Shenglin Ma, Yong Song, Youcai Zhu, Yuanzhi Lu, Meiyu Fang   +112 more
wiley   +1 more source

Targeting Cancer Stem Cells with Radioimmunotherapy: The Case of the Ovarian Cancer Stemness-Associated Biomarker L1CAM

International Journal of Translational Medicine
Cancer stem cells (CSCs) are a dynamic population of tumor cells characterized by long-term self-renewal, high tumorigenicity, resistance to conventional therapies such as radio- and chemotherapy, and capacity to recapitulate the tumor heterogeneity ...
Tihomir Zh. Todorov, Roger Schibli, Martin Béhé, Jürgen Grünberg   +3 more
doaj   +1 more source

Combining Albumin-Binding Properties and Interaction with Pemetrexed to Improve the Tissue Distribution of Radiofolates

Molecules, 2018
Folic-acid-based radioconjugates have been developed for nuclear imaging of folate receptor (FR)-positive tumors; however, high renal uptake was unfavorable in view of a therapeutic application.
Cristina Müller, Patrycja Guzik, Klaudia Siwowska, Susan Cohrs, Raffaella M. Schmid, Roger Schibli   +5 more
doaj   +1 more source

New methods for introducing 75Se into radiopharmaceuticals [PDF]

, 1975
Garabed P. Basmadjian, Kenneth R. Hetzel, Rodney D. Ice   +2 more
openalex   +1 more source

Trajectories of Pontine Volume in Patients with Multiple System Atrophy

Movement Disorders, EarlyView.
Abstract Objectives To investigate trajectories of regional brain volume changes in multiple system atrophy (MSA) and their potential utility as surrogate markers of disease progression in the cerebellar subtype (MSA‐C). Background Reliable biomarkers for tracking disease progression in MSA are urgently needed.
Kazuya Kawabata, Florian Krismer, Mizuki Ito, Kazuhiro Hara, Epifanio Bagarinao, Vincent Beliveau, Patrice Péran, Germain Arribarat, Anne Pavy‐Le Traon, Wassilios G. Meissner, Alexandra Foubert‐Samier, Margherita Fabbri, Mark Forrest Gordon, Aya Ogura, Masahisa Katsuno, Olivier Rascol, Christoph Scherfler, Klaus Seppi, Hirohisa Watanabe, Werner Poewe   +19 more
wiley   +1 more source

Results of a Geant4 benchmarking study for bio‐medical applications, performed with the G4‐Med system

Medical Physics, EarlyView.
Abstract Background Geant4, a Monte Carlo Simulation Toolkit extensively used in bio‐medical physics, is in continuous evolution to include newest research findings to improve its accuracy and to respond to the evolving needs of a very diverse user community.
Pedro Arce, Jay W. Archer, Lorenzo Arsini, Alexander Bagulya, David Bolst, Jeremy M. C. Brown, Barbara Caccia, Andrew Chacon, Giuseppe Antonio Pablo Cirrone, Miguel Antonio Cortés‐Giraldo, Dean Cutajar, Giacomo Cuttone, Paolo Dondero, Andrea Dotti, Bruce Faddegon, Serena Fattori, Christian Fedon, Susanna Guatelli, Akihiro Haga, Sebastien Incerti, Vladimir Ivanchenko, Dmitri Konstantinov, Ioanna Kyriakou, Albert Le, Zhuxin Li, Michel Maire, Alessandra Malaroda, Carlo Mancini‐Terracciano, Alfonso Mantero, Claire Michelet, Giuliana Milluzzo, Francesca Nicolanti, Mihaly Novak, Chihiro Omachi, Luciano Pandola, Jake Harold Pensavalle, Álvaro Perales, Yann Perrot, Giada Petringa, Silvia Pozzi, José Manuel Quesada, José Ramos‐Méndez, Francesco Romano, Anatoly B. Rosenfeld, Mitra Safavi‐Naeini, Dousatsu Sakata, Luis G. Sarmiento, Takashi Sasaki, Yoshihide Sato, Alberto Sciuto, Ioannis Sechopoulos, Edward C. Simpson, Ronny Stanzani, Alessandra Tomal, Toshiyuki Toshito, Hoang Ngoc Tran, Christopher White, Dennis H. Wright   +57 more
wiley   +1 more source

Mathematical Modeling of $^{18}$F-Fluoromisonidazole ($^{18}$F-FMISO) Radiopharmaceutical Transport in Vascularized Solid Tumors [PDF]

arXiv
$^{18}$F-Fluoromisonidazole ($^{18}$F-FMISO) is a highly promising positron emission tomography radiopharmaceutical for identifying hypoxic regions in solid tumors. This research employs spatiotemporal multi-scale mathematical modeling to explore how different levels of angiogenesis influence the transport of radiopharmaceuticals within tumors. In this
arxiv