Results 41 to 50 of about 34,120 (225)

Influence of Storage Temperature on Radiochemical Purity of 99mTc-Radiopharmaceuticals [PDF]

, 2018
The influence of effective room temperature on the radiochemical purity of 99mTc-radiopharmaceuticals was reported. This study was born from the observation that in the isolators used for the preparation of the 99mTc-radiopharmaceuticals the ...
Bartolomei, Mirco, Boschi, Alessandra, Cittanti, Corrado, Donatella, Farina, Doretta, Bortolotti, Elena, Govoni, Elisa, Zappaterra, Giganti, Melchiore, Luca, Lodi, Martini, Petra, Rizzo, Carlotta, Samanta, Zaccaria, Simona, Romani, Stefania, Bertelli, Uccelli, Licia   +14 more
core   +2 more sources

Immunotheranostic target modules for imaging and navigation of UniCAR T-cells to strike FAP-expressing cells and the tumor microenvironment

Journal of Experimental & Clinical Cancer Research, 2023
Background Chimeric antigen receptor (CAR) T-cells are a promising approach in cancer immunotherapy, particularly for treating hematologic malignancies.
Liliana R. Loureiro, Lydia Hoffmann, Christin Neuber, Luise Rupp, Claudia Arndt, Alexandra Kegler, Manja Kubeil, Christoph E. Hagemeyer, Holger Stephan, Marc Schmitz, Anja Feldmann, Michael Bachmann   +11 more
doaj   +1 more source

Overexpression of Receptor Tyrosine Kinase EphB4 Triggers Tumor Growth and Hypoxia in A375 Melanoma Xenografts: Insights from Multitracer Small Animal Imaging Experiments

Molecules, 2018
Experimental evidence has associated receptor tyrosine kinase EphB4 with tumor angiogenesis also in malignant melanoma. Considering the limited in vivo data available, we have conducted a systematic multitracer and multimodal imaging investigation in ...
Christin Neuber, Birgit Belter, Sebastian Meister, Frank Hofheinz, Ralf Bergmann, Hans-Jürgen Pietzsch, and Jens Pietzsch   +6 more
doaj   +1 more source

Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers. [PDF]

, 2017
Occult bacterial infections represent a worldwide health problem. Differentiating active bacterial infection from sterile inflammation can be difficult using current imaging tools. Present clinically viable methodologies either detect morphologic changes
Blecha, Joseph E, Flavell, Robert R, Kwak, Tiffany, Mutch, Christopher A, Neumann, Kiel D, Ohliger, Michael A, Rosenberg, Oren S, Sriram, Renuka, VanBrocklin, Henry F, Villanueva-Meyer, Javier E, Wilson, David M   +10 more
core   +1 more source

Pyridyl-Ala in the third position of radiolabeled somatostatin antagonists: the effect of regioisomeric substitution

EJNMMI Radiopharmacy and Chemistry
Background The radiolabeled somatostatin receptor subtype 2 (SST2) antagonists LM3 (Phe(4-Cl)1‐c(dCys2‐Tyr3‐dAph(Cbm)4‐Lys5‐Thr6‐Cys7)-dTyr8-NH2) and JR11 (Phe(4-Cl)1‐c(dCys2‐Aph(Hor)3‐dAph(Cbm)4‐Lys5‐Thr6‐Cys7)-dTyr8-NH2) are under clinical evaluation ...
Rosalba Mansi, Natalie Bertarelli, Luigi Del Pozzo, Sandra Zanger, Tais Basaco Bernabeu, Helmut Maecke, Melpomeni Fani   +6 more
doaj   +1 more source

Stability of Silver Nanoparticles as Imaging Materials [PDF]

Journal of Pure and Applied Chemistry Research, 2016
Determining the stability of silver nanoparticles is a very important process. It was associated with unwanted metal charge and materials properties. Therefore, we studied to synthesis and stability of silver nanoparticles (AgNPs).
Umi Nur Sholikhah, Anung Pujiyanto, Enny Lestari, Endang Sarmini, Triani Widyaningrum, Kadarisman, Triyanto, Putri Puspitasari   +7 more
doaj   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Internal radiation dose assessment of radiopharmaceuticals prepared with cyclotron-produced 99m Tc [PDF]

, 2019
Technetium-99m (99m Tc) is the radioisotope most widely used in diagnostic nuclear medicine. It is readily available from 99 Mo/99m Tc generators as the \u3b2- decay product of the 99 Mo (T\ubd =66 h) parent nuclide.
Bello, Michele, De Nardo, Laura, Esposito, Juan, Ferro-Flores, Guillermina, Mel\ue9ndez-Alafort, Laura, Negri, Anna, Paiusco, Marta, Rosato, Antonio, Uzunov, Nikolay, Zorz, Alessandra   +9 more
core   +1 more source

Neuropsychiatric Symptoms Mimicking Dementia in a Patient Treated With Imatinib

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Tyrosine kinase inhibitors are the cornerstone of chronic myeloid leukemia treatment. Newer agents have more potency and a broader spectrum of action, but also a higher potential for neuropsychiatric side effects. We present a case of a patient on imatinib who developed progressive cognitive, mood, and behavioral alterations.
Ashley Jones, Samuele Bonomi, Keith E. Stockerl‐Goldstein, Randall J. Bateman   +3 more
wiley   +1 more source

First-in-man evaluation of 124I-PGN650: A PET tracer for detecting phosphatidylserine as a biomarker of the solid tumor microenvironment [PDF]

, 2017
Purpose: PGN650 is a F(ab′) 2 antibody fragment that targets phosphatidylserine (PS), a marker normally absent that becomes exposed on tumor cells and tumor vasculature in response to oxidative stress and increases in response to therapy.
Dehdashti, Farrokh, Freimark, Bruce D, Frye, Jennifer, Frye, Sarah, Laforest, Richard, Liu, Yongjian, Luehmann, Hannah, Shan, Joseph S, Siegel, Barry A, Sultan, Deborah   +9 more
core   +2 more sources