Results 41 to 50 of about 22,462 (308)

Cyclotron production and radiochemical purification of terbium-155 for SPECT imaging

EJNMMI Radiopharmacy and Chemistry, 2021
Background Terbium-155 [T1/2 = 5.32 d, Eγ = 87 keV (32%) 105 keV (25%)] is an interesting radionuclide suitable for single photon emission computed tomography (SPECT) imaging with potential application in the diagnosis of oncological disease.
C. Favaretto, Z. Talip, F. Borgna, P. V. Grundler, G. Dellepiane, A. Sommerhalder, H. Zhang, R. Schibli, S. Braccini, C. Müller, N. P. van der Meulen   +10 more
doaj   +1 more source

The Role of Transglutaminase 2 in the Radioresistance of Melanoma Cells

Cells, 2022
Transglutaminase 2 (TG2) is a protein expressed in many tissues that exerts numerous, sometimes contradictory, intra- and extracellular functions, under both physiological and pathophysiological conditions.
Julia Aepler, Johanna Wodtke, Robert Wodtke, Cathleen Haase-Kohn, Reik Löser, Jens Pietzsch, Sandra Hauser   +6 more
doaj   +1 more source

Prostate cancer aggressiveness and financial toxicity among prostate cancer patients

The Prostate, Volume 83, Issue 1, Page 44-55, January 1, 2023., 2023
Abstract Introduction Financial toxicity (FT) is a growing concern among cancer survivors that adversely affects the quality of life and survival. Individuals diagnosed with aggressive cancers are often at a greater risk of experiencing FT. The objectives of this study were to estimate FT among prostate cancer (PCa) survivors after 10−15 years of ...
Madhav KC, Evrim Oral, Ariane L. Rung, Edward Trapido, Laura S. Rozek, Elizabeth T. H. Fontham, Jeannette T. Bensen, Laura Farnan, Susan E. Steck, Lixin Song, James L. Mohler, Saira Khan, Sanah Vohra, Edward S. Peters   +13 more
wiley   +1 more source

What is the Potential Impact of the IsoDAR Cyclotron on Radioisotope Production: A Review [PDF]

EJNMMI Radiopharmacy and Chemistry 5:6 (2020), 2018
The IsoDAR collaboration is developing a high-current cyclotron for a neutrino search experiment. Designed to deliver 10 mA of 60 MeV protons, the current and power of this cyclotron far exceed those of existing accelerators, opening new possibilities for the production of radiopharmaceutical isotopes, producing very high-activity samples in very short
arxiv   +1 more source

Cyclotron-Based Production of ⁶⁷Cu for Radionuclide Theranostics via the ⁷⁰Zn(p,α)⁶⁷Cu Reaction

Pharmaceuticals, 2023
Theranostic matched pairs of radionuclides have aroused interest during the last couple of years, and in that sense, copper is one element that has a lot to offer, and although 61Cu and 64Cu are slowly being established as diagnostic radionuclides for ...
Santiago Andrés Brühlmann, Martin Walther, Martin Kreller, Falco Reissig, Hans-Jürgen Pietzsch, Torsten Kniess, Klaus Kopka   +6 more
doaj   +1 more source

Reducing kidney uptake of radiolabelled exendin-4 using variants of the renally cleavable linker MVK

EJNMMI Radiopharmacy and Chemistry, 2023
Background Peptidic radiotracers are preferentially excreted through the kidneys, which often results in high persistent renal retention of radioactivity, limiting or even preventing therapeutic clinical translation of these radiotracers.
Belinda Trachsel, Giulia Valpreda, Alexandra Lutz, Roger Schibli, Linjing Mu, Martin Béhé   +5 more
doaj   +1 more source

Epigenome‐wide association study, meta‐analysis, and multiscore profiling of whole blood in Parkinson's disease

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objectives An increasing body of evidence indicates altered DNA methylation in Parkinson's disease, yet the reproducibility and utility of such methylation changes are largely unexplored. We aimed to further elucidate the role of dysregulated DNA methylation in Parkinson's disease and to evaluate the biomarker potential of methylation‐based ...
Ingeborg Haugesag Lie, Manuela M. X. Tan, Maren Stolp Andersen, Mathias Toft, Lasse Pihlstrøm   +4 more
wiley   +1 more source

A projection-domain low-count quantitative SPECT method for alpha-particle emitting radiopharmaceutical therapy [PDF]

arXiv, 2021
Single-photon emission computed tomography (SPECT) provides a mechanism to estimate regional isotope uptake in lesions and at-risk organs after administration of {\alpha}-particle-emitting radiopharmaceutical therapies ({\alpha}-RPTs). However, this estimation task is challenging due to the complex emission spectra, the very low number of detected ...
arxiv  

Preclinical Incorporation Dosimetry of [¹⁸F]FACH—A Novel ¹⁸F-Labeled MCT1/MCT4 Lactate Transporter Inhibitor for Imaging Cancer Metabolism with PET

Molecules, 2020
Overexpression of monocarboxylate transporters (MCTs) has been shown for a variety of human cancers (e.g., colon, brain, breast, and kidney) and inhibition resulted in intracellular lactate accumulation, acidosis, and cell death. Thus, MCTs are promising
Bernhard Sattler, Mathias Kranz, Barbara Wenzel, Nalin T. Jain, Rareş-Petru Moldovan, Magali Toussaint, Winnie Deuther-Conrad, Friedrich-Alexander Ludwig, Rodrigo Teodoro, Tatjana Sattler, Masoud Sadeghzadeh, Osama Sabri, Peter Brust   +12 more
doaj   +1 more source

Early BMI Change, Cognitive Decline, and CSF AD Biomarkers Alterations in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the relationship of early BMI change with subsequent cognitive decline, CSF AD biomarkers alterations, and progression to dementia in patients with PD. Methods Study data were prospectively collected from the PPMI cohort. Weight/height data at enrollment and second‐year clinical visit were utilized to calculate BMI change.
Rui Zhong, Kezhong Zhang
wiley   +1 more source